Berberine alleviates NLRP3 inflammasome induced endothelial junction dysfunction through Ca2+ signalling in inflammatory vascular injury

Serum exosomal miR‐638 is a prognostic marker of HCC via downregulation of VE‐cadherin and ZO‐1 of endothelial cells

(2021) Yuki Yokota et al.   CANCER SCIENCE

Pelargonic acid vanillylamide and rosuvastatin protect against oxidized low-density lipoprotein-induced endothelial dysfunction by inhibiting the NF-κB/NLRP3 pathway and improving cell-cell junctions

(2021) Sivanan Sivasinprasasn et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy

(2021) YanZhi Zhang et al.   PHYTOMEDICINE

A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes

(2021) Stephen A. Harrison et al.   Nature Communications

Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway

(2021) Hyun-Ju Kim et al.   Scientific Reports

Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction

(2020) Niké Posta et al.   LABORATORY INVESTIGATION

Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders

(2020) Wei-Jia Kong et al.   PHARMACOLOGY & THERAPEUTICS

Berberine protects Kawasaki disease-induced human coronary artery endothelial cells dysfunction by inhibiting of oxidative and endoplasmic reticulum stress

(2020) Mingguo Xu et al.   VASCULAR PHARMACOLOGY

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

(2020) Weijian Mai et al.   Frontiers in Pharmacology

NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases

(2020) Yeqing Tong et al.   Oxidative Medicine and Cellular Longevity

Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE−/− Mice

(2020) Min Wu et al.   Frontiers in Pharmacology

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

(2020) Yifan Jia et al.   Redox Biology

Aloe emodin relieves Ang II‐induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation

(2020) Yi Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of ERRα Aggravates Sepsis-Induced Acute Lung Injury in Rats via Provoking Inflammation and Oxidative Stress

(2020) Wenfang Xia et al.   Oxidative Medicine and Cellular Longevity

NLRP3 inflammasome in endothelial dysfunction

(2020) Baochen Bai et al.   Cell Death & Disease

Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity

(2020) Qingxuan Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics

(2020) Qing Lu et al.   Redox Biology

Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury

(2019) Xing Zhou et al.   Acta Pharmaceutica Sinica B

Berberine inhibits low shear stress-induced glycocalyx degradation via modulating AMPK and p47phox/Hyal2 signal pathway

(2019) Hongfeng Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis

(2019) Xin Qin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease

(2019) Xin Cong et al.   CELLULAR SIGNALLING

Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis

(2018) Yan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chronic Infusion of Berberine into the Hypothalamic Paraventricular Nucleus Attenuates Hypertension and Sympathoexcitation via the ROS/Erk1/2/iNOS Pathway

(2018) Hua Tian et al.   PHYTOMEDICINE

Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS

(2018) Lina Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

(2014) Tiffany Horng   TRENDS IN IMMUNOLOGY

The C-Terminus of Human Nucleotide Receptor P2X7 Is Critical for Receptor Oligomerization and N-Linked Glycosylation

(2013) Lisa E. Wickert et al.   PLoS One