Blocking of Caveolin-1 Attenuates Morphine-Induced Inflammation, Hyperalgesia, and Analgesic Tolerance via Inhibiting NLRP3 Inflammasome and ERK/c-JUN Pathway

The protective effects of curcumin in cerebral ischemia and reperfusion injury through PKC-θ signaling

(2021) Yun Mo et al.   CELL CYCLE

The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

(2021) Ruixiang Chen et al.   Journal of Neuroinflammation

In vivo reduction of hippocampal Caveolin-1 by RNA interference alters morphine addiction and neuroplasticity changes in male mice

(2021) Shanshan Wang et al.   NEUROSCIENCE LETTERS

Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway

(2021) Kumaravel Mohankumar et al.   MOLECULAR BIOLOGY REPORTS

Chronic morphine-induced changes in signaling at the A3 adenosine receptor contribute to morphine-induced hyperalgesia, tolerance and withdrawal.

(2020) Timothy M. Doyle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation

(2020) Qianjin Liu et al.   Redox Biology

Neuroprotective effects of curcumin against rats with focal cerebral ischemia-reperfusion injury

(2019) Lu Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Curcumin induces apoptosis in JAK2‐mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways

(2019) Jessica Petiti et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice

(2019) Juan Wang et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway

(2019) Xinyu Lin et al.   PLoS One

Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia

(2019) Bárbara Guimaraes de Freitas et al.   Frontiers in Neuroscience

Curcumin Attenuates Adipogenesis by Inducing Preadipocyte Apoptosis and Inhibiting Adipocyte Differentiation

(2019) Liang-Yi Wu et al.   Nutrients

Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/IκB Kinase β (IKKβ)/Nuclear Factor Kappa B (NF-κB) Pathway in Microglia

(2019) Feng Gao et al.   MEDICAL SCIENCE MONITOR

Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells

(2018) Shanshan Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain

(2018) Fang Gao et al.   BRAIN BEHAVIOR AND IMMUNITY

Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation

(2018) Wanli Zhao et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The Effect of BSA-Based Curcumin Nanoparticles on Memory and Hippocampal MMP-2, MMP-9, and MAPKs in Adult Mice

(2018) Roksana SoukhakLari et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis

(2018) Zhiqiang Pan et al.   Journal of Neuroinflammation

Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway

(2017) Sandeep Shrestha et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

(2017) Jie Qu et al.   Journal of Neuroinflammation

Peripheral neuropathies: Long-term opioid therapy in neuropathy: benefit or harm?

(2017) Claudia Sommer   Nature Reviews Neurology

Caveolin-1 scaffolding domain peptides enhance anti-inflammatory effect of heme oxygenase-1 through interrupting its interact with caveolin-1

(2017) Ping Weng et al.   Oncotarget

Chronic opioid treatment augments caveolin-1 scaffolding: relevance to stimulatory μ-opioid receptor adenylyl cyclase signaling

(2016) Sumita Chakrabarti et al.   JOURNAL OF NEUROCHEMISTRY

Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

(2016) Yang Cai et al.   Journal of Neuroinflammation

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

(2016) Lori N Eidson et al.   NEUROPSYCHOPHARMACOLOGY

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

(2016) Laurie-Anne Roeckel et al.   NEUROSCIENCE

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

(2016) Keren Zhou et al.   Journal of Immunology Research

Inhibition of spinal ERK1/2–c-JUN signaling pathway counteracts the development of low doses morphine-induced hyperalgesia

(2015) Maria Domenica Sanna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia

(2015) Peter M. Grace et al.   HEADACHE

Caveolin-1 in the Anterior Cingulate Cortex Modulates Chronic Neuropathic Pain via Regulation of NMDA Receptor 2B Subunit

(2015) J.-X. Yang et al.   JOURNAL OF NEUROSCIENCE

Tolerance to the Antinociceptive Effects of Chronic Morphine Requires C-Jun N-Terminal Kinase

(2015) David J. Marcus et al.   Molecular Pain

Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

(2015) Stéphane Mélik Parsadaniantz et al.   NATURE REVIEWS NEUROSCIENCE

Change in functional selectivity of morphine with the development of antinociceptive tolerance

(2014) T A Macey et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: A step toward improving opioid pain therapy

(2014) Maria Domenica Sanna et al.   NEUROPHARMACOLOGY

MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells

(2013) Teng Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Doctor's Dilemma: Opiate Analgesics and Chronic Pain

(2011) Howard L. Fields   NEURON

Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells

(2010) Ji Hae Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

(2010) C. Muscoli et al.   JOURNAL OF NEUROSCIENCE

Effects of chronic inflammation and morphine tolerance on the expression of phospho-ERK 1/2 and phospho-P38 in the injured tissue

(2008) Pilar Almela et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules

(2007) Hemal H. Patel et al.   Annual Review of Pharmacology and Toxicology