Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions

PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing

(2023) Eulashini Chuntharpursat-Bon et al.   Communications Biology

TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels

(2023) Wang Zheng et al.   Neuron

MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels

(2023) Zijing Zhou et al.   SCIENCE

A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity

(2023) Mingfeng Zhang et al.   Nature Communications

Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation

(2022) Hailin Liu et al.   Frontiers in Immunology

Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications

(2022) Yuyang Sun et al.   Frontiers in Cell and Developmental Biology

Piezo1 and IFT88 synergistically regulate mandibular condylar chondrocyte differentiation under cyclic tensile strain

(2022) Zhuoyu Zhang et al.   TISSUE & CELL

Mechanosensitive Piezo1 channels mediate renal fibrosis

(2022) Xiaoduo Zhao et al.   JCI Insight

Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling

(2022) Yijia Pan et al.   EMBO JOURNAL

Piezo1 Response to Shear Stress Is Controlled by the Components of the Extracellular Matrix

(2022) Austin Lai et al.   ACS Applied Materials & Interfaces

Piezo1 act as a potential oncogene in pancreatic cancer progression

(2022) Zeen Zhu et al.   LIFE SCIENCES

Membrane curvature governs the distribution of Piezo1 in live cells

(2022) Shilong Yang et al.   Nature Communications

Piezo1 as a force-through-membrane sensor in red blood cells

(2022) George Vaisey et al.   eLife

Force- and cell state–dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry

(2022) Mingxi Yao et al.   Science Advances

Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing

(2021) Ramona Emig et al.   Cells

Selective killing of transformed cells by mechanical stretch

(2021) Ajay Tijore et al.   BIOMATERIALS

Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer

(2021) Jia-Lin Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Enhanced tumor cell killing by ultrasound after microtubule depolymerization

(2021) Aditi Singh et al.   Bioengineering & Translational Medicine

Mechanosensing by Piezo1 and its implications for physiology and various pathologies

(2021) Austin Lai et al.   BIOLOGICAL REVIEWS

The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration

(2021) Brenda Canales Coutiño et al.   DEVELOPMENT

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

(2021) Jesse R Holt et al.   eLife

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway

(2021) Yuanyuan Fu et al.   Frontiers in Cell and Developmental Biology

The roles of mechanosensitive ion channels and associated downstream MAPK signaling pathways in PDLC mechanotransduction

(2020) Yun Shen et al.   Molecular Medicine Reports

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

(2020) Lijun Wang et al.   Nature Communications

The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism

(2020) Yanhua Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice

(2020) ShengPeng Wang et al.   Nature Communications

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

(2020) Ryan S D'Souza et al.   eLife

Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway

(2020) Yi Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts

(2020) Francesca Aglialoro et al.   Frontiers in Physiology

Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development

(2020) Ting-ting Liu et al.   NEURON

Shear stress induces pathological changes in endothelial cells through Piezo1 activation of TRPV4

(2020) Sandip M. Swain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration

(2019) Zhicheng Huang et al.   BIOSCIENCE REPORTS

A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions

(2019) Nisha Bte Mohd Rafiq et al.   NATURE MATERIALS

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing

(2019) Michael Sheetz   Annual Review of Cell and Developmental Biology

Mammalian TRP ion channels are insensitive to membrane stretch

(2019) Yury A. Nikolaev et al.   JOURNAL OF CELL SCIENCE

Stopping transformed cancer cell growth by rigidity sensing

(2019) Bo Yang et al.   NATURE MATERIALS

Bacterial Mechanosensors

(2018) Charles D. Cox et al.   Annual Review of Physiology

PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis

(2018) Jinglin Zhang et al.   MOLECULAR CARCINOGENESIS

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

(2018) Julián Albarrán-Juárez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

(2018) Xin Chen et al.   NEURON

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation

(2018) Keiko Nonomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

(2018) Swetha E Murthy et al.   eLife

Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction

(2017) Kazumasa Ohashi et al.   JOURNAL OF BIOCHEMISTRY

Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance

(2017) Patrick C. Kerstein et al.   JOURNAL OF NEUROSCIENCE

Mechanical Stimulation of Piezo1 Receptors Depends on Extracellular Matrix Proteins and Directionality of Force

(2017) Benjamin M. Gaub et al.   NANO LETTERS

Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

(2017) Mayur Saxena et al.   NANO LETTERS

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells

(2017) Asuna Sugimoto et al.   Scientific Reports

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

Differentiation of Normal and Cancer Cell Adhesion on Custom Designed Protein Nanopatterns

(2015) Utku Horzum et al.   NANO LETTERS

Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis

(2015) Elisavet Fotiou et al.   Nature Communications

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line

(2015) Chouyang Li et al.   Scientific Reports

Ca2+Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis

(2015) Feng-Chiao Tsai et al.   Biomed Research International

TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility

(2015) Mónica Cáceres et al.   PLoS One

Mechanical properties of fibroblasts depend on level of cancer transformation

(2014) Yu.M. Efremov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

(2014) Kate Poole et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Compartmentalized Calcium Transients Trigger Dendrite Pruning in Drosophila Sensory Neurons

(2013) T. Kanamori et al.   SCIENCE

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration

(2012) Brian J. McHugh et al.   PLoS One

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

Calpain-mediated Proteolysis of Paxillin Negatively Regulates Focal Adhesion Dynamics and Cell Migration

(2011) Christa L. Cortesio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)

(2010) Keefe T. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

(2009) Reza Sharif-Naeini et al.   CELL

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum

(2009) B. J. McHugh et al.   JOURNAL OF CELL SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE