Shear stress induces pathological changes in endothelial cells through Piezo1 activation of TRPV4

The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton

(2020) Mehdi Inglebert et al.   Biomicrofluidics

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation

(2020) Sandip M. Swain et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-144 Mediated Inhibition of ROCK1 Protects Against LPS Induced Lung Endothelial Hyperpermeability

(2019) M Rizwan Siddiqui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

(2019) Celine Souilhol et al.   Nature Reviews Cardiology

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanosensitive Piezo1 channel is required for bone formation

(2019) Weijia Sun et al.   eLife

Force Sensing by Piezo Channels in Cardiovascular Health and Disease

(2019) David J. Beech et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling

(2019) Calum Wilson et al.   HYPERTENSION

Endothelial Cell Calcium Signaling during Barrier Function and Inflammation

(2019) Prarthana J. Dalal et al.   AMERICAN JOURNAL OF PATHOLOGY

Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A–mediated phosphorylation

(2018) Sheng Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

(2018) Joelle M.-J. Romac et al.   Nature Communications

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

(2018) Julián Albarrán-Juárez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fluid shear stress sensing in vascular homeostasis and remodeling: Towards the development of innovative pharmacological approaches to treat vascular dysfunction

(2018) Nicolas Baeyens   BIOCHEMICAL PHARMACOLOGY

Regulation of endothelial barrier integrity by redox-dependent nitric oxide signaling: Implication in traumatic and inflammatory brain injuries

(2018) Seungho Choi et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells

(2017) Tam T. T. Phuong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization

(2017) Adrienne E. Dubin et al.   NEURON

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function

(2016) Judith A. Stolwijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis

(2016) Suowen Xu et al.   Oncotarget

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

(2016) Daniel A. Ryskamp et al.   Scientific Reports

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

(2014) Jing Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased monocyte adhesion by endothelial expression of VCAM-1 missense variation in vitro

(2013) Boris Schmitz et al.   ATHEROSCLEROSIS

Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

(2012) S. K. Sonkusare et al.   SCIENCE

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling

(2011) Aaron H. Bubolz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

(2011) A Fiorio Pla et al.   ONCOGENE

Flow Shear Stress and Atherosclerosis: A Matter of Site Specificity

(2010) Patrizia Nigro et al.   ANTIOXIDANTS & REDOX SIGNALING

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation

(2010) N Vergnolle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

(2009) Suelhem A. Mendoza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation

(2009) Hueng-Chuen Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+Influx and ATP Release in Primary Urothelial Cell Cultures

(2009) Tsutomu Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation

(2008) Annemarieke E. Loot et al.   CARDIOVASCULAR RESEARCH

Role of the cytoskeleton in flow (shear stress)-induced dilation and remodeling in resistance arteries

(2008) Laurent Loufrani et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player

(2008) Dietmar Vestweber et al.   TRENDS IN CELL BIOLOGY

High Vascular Pressure–Induced Lung Injury Requires P450 Epoxygenase–Dependent Activation of TRPV4

(2007) Ming-Yuan Jian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY