Selective killing of transformed cells by mechanical stretch

WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

(2020) Irene Rodriguez-Hernandez et al.   Nature Communications

Mechanics and Actomyosin-Dependent Survival/Chemoresistance of Suspended Tumor Cells in Shear Flow

(2019) Ying Xin et al.   BIOPHYSICAL JOURNAL

Large and reversible myosin-dependent forces in rigidity sensing

(2019) James Lohner et al.   Nature Physics

A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing

(2019) Michael Sheetz   Annual Review of Cell and Developmental Biology

Stopping transformed cancer cell growth by rigidity sensing

(2019) Bo Yang et al.   NATURE MATERIALS

Determination of the Elastic Moduli of a Single Cell Cultured on a Rigid Support by Force Microscopy

(2018) Pablo D. Garcia et al.   BIOPHYSICAL JOURNAL

A novel anti-cancer agent, FPDHP, induces anoikis in various human cancer cells through activation of calpain, and downregulation of anoikis-related molecules

(2018) Seon Goo Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

(2018) Jianjun Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Prostate Cancer – Local Treatment after Radiorecurrence: HIFU – High-Intensity Focused Ultrasound

(2018) Stênio de Cássio Zequi et al.   International Braz J Urol

Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model

(2018) L. Berrueta et al.   Scientific Reports

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

(2018) Feifei Liu et al.   Acta Pharmaceutica Sinica B

Combining doxorubicin-nanobubbles and shockwaves for anaplastic thyroid cancer treatment: preclinical study in a xenograft mouse model

(2017) Francesca Marano et al.   ENDOCRINE-RELATED CANCER

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

High Shear Stresses under Exercise Condition Destroy Circulating Tumor Cells in a Microfluidic System

(2017) Sagar Regmi et al.   Scientific Reports

Mechanosensing Controlled Directly by Tyrosine Kinases

(2016) Bo Yang et al.   NANO LETTERS

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

(2016) Jing Fang et al.   NATURE MEDICINE

Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?

(2016) S Baig et al.   Cell Death & Disease

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

(2016) Sandra Kümper et al.   eLife

Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices

(2016) Jack R. Staunton et al.   Scientific Reports

Modulation of Murine Breast Tumor Vascularity, Hypoxia, and Chemotherapeutic Response by Exercise

(2015) Allison S. Betof et al.   JNCI-Journal of the National Cancer Institute

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

(2015) Haguy Wolfenson et al.   NATURE CELL BIOLOGY

Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing

(2015) Hsi-Hui Lin et al.   Oncotarget

Modulation of Murine Breast Tumor Vascularity, Hypoxia, and Chemotherapeutic Response by Exercise

(2015) Allison S. Betof et al.   JNCI-Journal of the National Cancer Institute

Mechanical regulation of cancer cell apoptosis and autophagy: Roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK

(2013) Sheng-Chieh Lien et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

(2013) I Azimi et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells

(2013) J. R. Stehn et al.   CANCER RESEARCH

Telomere Length Influences Cancer Cell Differentiation In Vivo

(2013) K. Hirashima et al.   MOLECULAR AND CELLULAR BIOLOGY

Ultrasound sonication with microbubbles disrupts blood vessels and enhances tumor treatments of anticancer nanodrug

(2012) Win-Li Lin et al.   International Journal of Nanomedicine

Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma

(2012) WEI YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Human U87 Astrocytoma Cell Invasion Induced by Interaction of βig-h3 with Integrin α5β1 Involves Calpain-2

(2012) Jie Ma et al.   PLoS One

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL

(2011) Raghuveer Singh Mali et al.   CANCER CELL

Mechanical Stiffness Grades Metastatic Potential in Patient Tumor Cells and in Cancer Cell Lines

(2011) V. Swaminathan et al.   CANCER RESEARCH

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion

(2010) Yingjie Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor

(2009) J. Li et al.   CLINICAL CANCER RESEARCH

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

(2009) Souhila Medjkane et al.   NATURE CELL BIOLOGY