TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels
Authors
Keywords
-
Journal
Neuron
Volume 111, Issue 20, Pages 3195-3210.e7
Publisher
Elsevier BV
Online
2023-08-04
DOI
10.1016/j.neuron.2023.07.006
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- pH regulates potassium conductance and drives a constitutive proton current in human TMEM175
- (2022) Wang Zheng et al. Science Advances
- TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia
- (2022) Luis Carlos Tábara et al. BRAIN
- TRP channels in thermosensation
- (2022) Makiko Kashio et al. CURRENT OPINION IN NEUROBIOLOGY
- Physics of mechanotransduction by Piezo ion channels
- (2022) Michael Young et al. JOURNAL OF GENERAL PHYSIOLOGY
- PIEZO channels and newcomers in the mammalian mechanosensitive ion channel family
- (2022) Patrick Delmas et al. NEURON
- Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices
- (2022) Nurunisa Akyuz et al. Science Advances
- Structures of the TMC-1 complex illuminate mechanosensory transduction
- (2022) Hanbin Jeong et al. NATURE
- Genetic analysis of 20 patients with hypomyelinating leukodystrophy by trio-based whole-exome sequencing
- (2021) Huifang Yan et al. JOURNAL OF HUMAN GENETICS
- Spinal cord involvement and paroxysmal events in “Infantile Onset Transient Hypomyelination” due to TMEM63A mutation
- (2021) Davide Tonduti et al. JOURNAL OF HUMAN GENETICS
- Structural insights into the mechanisms and pharmacology of K2P potassium channels
- (2021) Andrew M. Natale et al. JOURNAL OF MOLECULAR BIOLOGY
- Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants
- (2021) Carl Procko et al. eLife
- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- A novel de novo TMEM63A variant in a patient with severe hypomyelination and global developmental delay
- (2021) Shinobu Fukumura et al. BRAIN & DEVELOPMENT
- Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
- (2020) Peng Jin et al. Annual Review of Neuroscience
- The Cation Channel TMEM63B Is an Osmosensor Required for Hearing
- (2020) Han Du et al. Cell Reports
- UCSF ChimeraX : Structure visualization for researchers, educators, and developers
- (2020) Eric F. Pettersen et al. PROTEIN SCIENCE
- The Mechanosensory Transduction Machinery in Inner Ear Hair Cells
- (2020) Wang Zheng et al. Annual Review of Biophysics
- Discoveries in structure and physiology of mechanically activated ion channels
- (2020) J. M. Kefauver et al. NATURE
- Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
- (2020) Ali Punjani et al. NATURE METHODS
- A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
- (2019) Wang Zheng et al. eLife
- Dietary fatty acids fine-tune Piezo1 mechanical response
- (2019) Luis O. Romero et al. Nature Communications
- Cryo-EM structure of OSCA1.2 fromOryza sativaelucidates the mechanical basis of potential membrane hyperosmolality gating
- (2019) Koustav Maity et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
- (2019) Shengjie Feng et al. Cell Reports
- Heterozygous Variants in the Mechanosensitive Ion Channel TMEM63A Result in Transient Hypomyelination during Infancy
- (2019) Huifang Yan et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
- (2019) Dominique Douguet et al. CELL
- The role of π-helices in TRP channel gating
- (2019) Lejla Zubcevic et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
- (2019) Charles D. Cox et al. Cell Reports
- The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel
- (2018) Christian J. Peters et al. NEURON
- Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases
- (2018) Arturo Medrano-Soto et al. PLoS One
- Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
- (2018) Wang Zheng et al. Nature Communications
- Real-space refinement in PHENIX for cryo-EM and crystallography
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- Structure of the mechanosensitive OSCA channels
- (2018) Mingfeng Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
- (2018) Bifeng Pan et al. NEURON
- Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2
- (2018) Xin Liu et al. Nature Communications
- OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
- (2018) Swetha E Murthy et al. eLife
- Cryo-EM structure of the mechanically activated ion channel OSCA1.2
- (2018) Sebastian Jojoa-Cruz et al. eLife
- A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis
- (2018) Jasenko Zivanov et al. IUCrJ
- Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
- (2017) Cristina Paulino et al. NATURE
- Cryo-EM structures of the TMEM16A calcium-activated chloride channel
- (2017) Shangyu Dang et al. NATURE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Piezos thrive under pressure: mechanically activated ion channels in health and disease
- (2017) Swetha E. Murthy et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Independent activation of distinct pores in dimeric TMEM16A channels
- (2016) Grace Jeng et al. JOURNAL OF GENERAL PHYSIOLOGY
- Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A
- (2016) Novandy K. Lim et al. JOURNAL OF GENERAL PHYSIOLOGY
- Mechanistic signs of double-barreled structure in a fluoride ion channel
- (2016) Nicholas B Last et al. eLife
- How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2
- (2015) Stephen G. Brohawn Annals of the New York Academy of Sciences
- Lipid–protein interactions: Lessons learned from stress
- (2015) A.R. Battle et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes
- (2014) Congcong Hou et al. CELL RESEARCH
- Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes
- (2014) Sviatoslav N. Bagriantsev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- X-ray structure of a calcium-activated TMEM16 lipid scramblase
- (2014) Janine D. Brunner et al. NATURE
- OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis
- (2014) Fang Yuan et al. NATURE
- Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
- (2014) April Goehring et al. Nature Protocols
- TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear
- (2013) Bifeng Pan et al. NEURON
- Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)
- (2013) J. Tien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae
- (2013) W. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Collaboration gets the most out of software
- (2013) Andrew Morin et al. eLife
- The MscS and MscL Families of Mechanosensitive Channels Act as Microbial Emergency Release Valves
- (2012) Ian R. Booth et al. JOURNAL OF BACTERIOLOGY
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation
- (2012) Zhiqiang Yan et al. NATURE
- A Role for K2P Channels in the Operation of Somatosensory Nociceptors
- (2012) Leigh D. Plant Frontiers in Molecular Neuroscience
- Constant electric field simulations of the membrane potential illustrated with simple systems
- (2011) James Gumbart et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started