Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain

Limited astrocyte-to-neuron conversion in the mouse brain using NeuroD1 overexpression

(2022) David Leib et al.   MOLECULAR THERAPY

Targeting PTB for Glia-to-Neuron Reprogramming In Vitro and In Vivo for Therapeutic Development in Neurological Diseases

(2022) Matilde Contardo et al.   Biomedicines

In vivo glia‐to‐neuron conversion: pitfalls and solutions

(2022) Lei‐Lei Wang et al.   Developmental Neurobiology

A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum

(2022) Yunjia Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

(2022) Weizhao Chen et al.   eLife

Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer’s mouse models

(2022) Tiantian Guo et al.   JOURNAL OF NEUROSCIENCE

Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis

(2022) Hong Han et al.   MOLECULAR CELL

Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions

(2022) Jessica A. Hensel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH

(2022) Rongxin Fang et al.   SCIENCE

Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

(2022) Thanh Hoang et al.   Cell Reports

Critical examination of Ptbp1-mediated glia-to-neuron conversion in the mouse retina

(2022) Ye Xie et al.   Cell Reports

Knockdown of polypyrimidine tract binding protein facilitates motor function recovery after spinal cord injury

(2022) Gang Chen et al.   Neural Regeneration Research

In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

(2021) Wenjiao Tai et al.   Cell Stem Cell

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Evidence and perspectives of cell senescence in neurodegenerative diseases

(2021) Zizhen Si et al.   BIOMEDICINE & PHARMACOTHERAPY

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

(2021) Álvaro Herrero-Navarro et al.   Science Advances

Brain Repair by Cell Replacement via In Situ Neuronal Reprogramming

(2021) Hao Qian et al.   Annual Review of Genetics

The Genome-Wide Binding Profile for Human RE1 Silencing Transcription Factor Unveils a Unique Genetic Circuitry in Hippocampus

(2021) James C. McGann et al.   JOURNAL OF NEUROSCIENCE

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

(2021) Roy Maimon et al.   NATURE NEUROSCIENCE

Treating Parkinson’s disease by astrocyte reprogramming: Progress and challenges

(2021) Zhuang-Yao D. Wei et al.   Science Advances

Genetic Constructs for the Control of Astrocytes’ Activity

(2021) Anastasia A. Borodinova et al.   Cells

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

(2021) Célia Lentini et al.   Cell Stem Cell

In vivo confusion over in vivo conversion

(2021) Gong Chen   MOLECULAR THERAPY

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

(2021) Riccardo Bocchi et al.   NEURON

Trajectory-based differential expression analysis for single-cell sequencing data

(2020) Koen Van den Berge et al.   Nature Communications

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon

(2020) Lin Lin et al.   NEURON

Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis

(2020) Jean-Pierre Roussarie et al.   NEURON

Single-cell RNA-seq analysis revealed long-lasting adverse effects of tamoxifen on neurogenesis in prenatal and adult brains

(2020) Chia-Ming Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Therapy for Neurodegenerative Diseases: Slowing Down the Ticking Clock

(2020) Raygene Martier et al.   Frontiers in Neuroscience

In vivo glial trans‐differentiation for neuronal replacement and functional recovery in central nervous system

(2020) Cheng Qian et al.   FEBS Journal

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Axonogenesis Is Coordinated by Neuron-Specific Alternative Splicing Programming and Splicing Regulator PTBP2

(2019) Min Zhang et al.   NEURON

Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreERT2 lines

(2019) A. Álvarez-Aznar et al.   TRANSGENIC RESEARCH

Sources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectors

(2019) Kyle B. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

(2018) Athena Georgilis et al.   CANCER CELL

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

New approaches for brain repair—from rescue to reprogramming

(2018) Roger A. Barker et al.   NATURE

Diverse mechanisms for endogenous regeneration and repair in mammalian organs

(2018) James M. Wells et al.   NATURE

Genome Toxicity and Impaired Stem Cell Function after Conditional Activation of CreERT2 in the Intestine

(2018) Natacha Bohin et al.   Stem Cell Reports

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons

(2017) Marc S. Weinberg et al.   MOLECULAR THERAPY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Genetic compensation: A phenomenon in search of mechanisms

(2017) Mohamed A. El-Brolosy et al.   PLoS Genetics

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism

(2016) S K Powell et al.   GENE THERAPY

Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells

(2016) Yuanchao Xue et al.   NATURE NEUROSCIENCE

The neurogenetics of alternative splicing

(2016) Celine K. Vuong et al.   NATURE REVIEWS NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Cre-dependent DNA recombination activates a STING-dependent innate immune response

(2016) Geneviève Pépin et al.   NUCLEIC ACIDS RESEARCH

PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing

(2016) John K. Vuong et al.   Cell Reports

Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

(2015) Fatma O. Kok et al.   DEVELOPMENTAL CELL

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

In vivo reprogramming for tissue repair

(2015) Christophe Heinrich et al.   NATURE CELL BIOLOGY

Cre recombinase induces DNA damage and tetraploidy in the absence ofLoxPsites

(2014) Vaibhao Janbandhu et al.   CELL CYCLE

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

(2014) Qin Li et al.   eLife

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites

(2013) Jason Gertz et al.   MOLECULAR CELL

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

PTB Deficiency Causes the Loss of Adherens Junctions in the Dorsal Telencephalon and Leads to Lethal Hydrocephalus

(2012) Takayuki Shibasaki et al.   CEREBRAL CORTEX

Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis

(2012) H. Aoki et al.   DEVELOPMENT

Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting

(2012) P. Arnold et al.   GENOME RESEARCH

Molecular Roadblocks for Cellular Reprogramming

(2012) Thomas Vierbuchen et al.   MOLECULAR CELL

PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

(2012) Sika Zheng et al.   NATURE NEUROSCIENCE

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

(2011) Meelad M. Dawlaty et al.   Cell Stem Cell

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

(2011) Kian Peng Koh et al.   Cell Stem Cell

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

(2011) J. R. Tollervey et al.   GENOME RESEARCH

The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells

(2011) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

The stem cell potential of glia: lessons from reactive gliosis

(2011) Stefanie Robel et al.   NATURE REVIEWS NEUROSCIENCE

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines

(2009) Hannah C. Cheung et al.   BRAIN

Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation

(2009) Masaki Shibayama et al.   FEBS Journal

Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT2

(2009) A. Y. Higashi et al.   JOURNAL OF IMMUNOLOGY

A Role for Polypyrimidine Tract Binding Protein in the Establishment of Focal Adhesions

(2009) I. Babic et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

(2009) Yuanchao Xue et al.   MOLECULAR CELL