Limited astrocyte-to-neuron conversion in the mouse brain using NeuroD1 overexpression

Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion

(2021) Brendan Puls et al.   Frontiers in Cell and Developmental Biology

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

(2021) Roy Maimon et al.   NATURE NEUROSCIENCE

Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy

(2021) Yu Tang et al.   Frontiers in Cell and Developmental Biology

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

In vivo confusion over in vivo conversion

(2021) Gong Chen   MOLECULAR THERAPY

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

(2020) Zheng Wu et al.   Nature Communications

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains

(2019) Wenliang Lei et al.   Frontiers in Neuroscience

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC 1 D-Driven Transgene Expression in AAV-Mediated Gene Transfer

(2017) Grit Taschenberger et al.   Molecular Therapy-Nucleic Acids

NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

(2017) Rebecca Brulet et al.   Stem Cell Reports

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

Engineering of Adult Neurogenesis and Gliogenesis

(2016) Benedikt Berninger et al.   Cold Spring Harbor Perspectives in Biology

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons

(2015) Katerina Aravantinou-Fatorou et al.   Stem Cell Reports

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Rational Design of Therapeutic siRNAs: Minimizing Off-targeting Potential to Improve the Safety of RNAi Therapy for Huntington's Disease

(2011) Ryan L Boudreau et al.   MOLECULAR THERAPY

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

Intraventricular Enzyme Replacement Improves Disease Phenotypes in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis

(2008) Michael Chang et al.   MOLECULAR THERAPY

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA