Genetic compensation: A phenomenon in search of mechanisms

Relative importance of βcyto- and γcyto-actin in primary mouse embryonic fibroblasts

(2017) Xiaobai Patrinostro et al.   MOLECULAR BIOLOGY OF THE CELL

Small RNA-directed epigenetic programming of embryonic stem cell cardiac differentiation

(2017) Hossein Ghanbarian et al.   Scientific Reports

Sequence-non-specific effects generated by various types of RNA interference triggers

(2016) Marta Olejniczak et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer

(2016) C. Speers et al.   CLINICAL CANCER RESEARCH

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

(2016) Talya L. Dayton et al.   GENES & DEVELOPMENT

Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications

(2016) Konstantin Licht et al.   JOURNAL OF CELL BIOLOGY

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases

(2016) Rong Chen et al.   NATURE BIOTECHNOLOGY

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

(2016) Bastiaan Evers et al.   NATURE BIOTECHNOLOGY

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes

(2016) David W Morgens et al.   NATURE BIOTECHNOLOGY

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

(2016) Benjamin E. Housden et al.   NATURE REVIEWS GENETICS

Health and population effects of rare gene knockouts in adult humans with related parents

(2016) V. M. Narasimhan et al.   SCIENCE

Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress

(2016) M Shatirishvili et al.   Cell Death & Disease

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression

(2015) Annika Schuermann et al.   ANGIOGENESIS

Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

(2015) Fatma O. Kok et al.   DEVELOPMENTAL CELL

Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes

(2015) Veronika Seiberlich et al.   GLIA

Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice

(2015) Jessica A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing

(2015) Li Li et al.   MOLECULAR CELL

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

Identification of a large set of rare complete human knockouts

(2015) Patrick Sulem et al.   NATURE GENETICS

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Auxin binding protein 1 (ABP1) is not required for either auxin signaling orArabidopsisdevelopment

(2015) Yangbin Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function

(2015) Anna Payne-Tobin Jost et al.   ACS Synthetic Biology

FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling

(2015) Siru Zhou et al.   PLoS Genetics

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

(2014) Shinya Yamamoto et al.   CELL

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

(2014) Schraga Schwartz et al.   CELL

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog

(2014) A. Hagelkruys et al.   DEVELOPMENT

Off-Target Effect of doublecortin Family shRNA on Neuronal Migration Associated with Endogenous MicroRNA Dysregulation

(2014) Seung Tae Baek et al.   NEURON

The Serine-Threonine Protein Kinase PAK4 Is Dispensable in Zebrafish: Identification of a Morpholino-Generated Pseudophenotype

(2014) Sheran H. W. Law et al.   PLoS One

The role of antisense long noncoding RNA in small RNA-triggered gene activation

(2014) Xizhe Zhang et al.   RNA

Transcriptional regulatory functions of nuclear long noncoding RNAs

(2014) Keith W. Vance et al.   TRENDS IN GENETICS

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

(2014) Yubao Wang et al.   eLife

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

Ribosome profiling reveals resemblance between long non-coding RNAs and 5′ leaders of coding RNAs

(2013) Guo-Liang Chew et al.   DEVELOPMENT

Biological Implications and Regulatory Mechanisms of Long-range Chromosomal Interactions

(2013) Zong Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Consequences of Deleting Any Single Gene

(2013) Xinchen Teng et al.   MOLECULAR CELL

Analysis of microRNA-target interactions across diverse cancer types

(2013) Anders Jacobsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A direct role for small non-coding RNAs in DNA damage response

(2013) Fabrizio d’Adda di Fagagna   TRENDS IN CELL BIOLOGY

The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1

(2013) Monique N. O'Leary et al.   PLoS Genetics

Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes

(2013) Emma A. Hall et al.   PLoS Genetics

A Role for Small RNAs in DNA Double-Strand Break Repair

(2012) Wei Wei et al.   CELL

IL-1β enhances cell adhesion to degraded fibronectin

(2012) Dhaarmini Rajshankar et al.   FASEB JOURNAL

Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition

(2012) Rui-Hong Wang et al.   International Journal of Biological Sciences

Cells Lacking β-Actin are Genetically Reprogrammed and Maintain Conditional Migratory Capacity*

(2012) Davina Tondeleir et al.   MOLECULAR & CELLULAR PROTEOMICS

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrPC-deficiency

(2012) N. Daude et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis

(2011) Jennifer Jurkin et al.   CELL CYCLE

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

(2011) Meelad M. Dawlaty et al.   Cell Stem Cell

Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells

(2011) JunYu Wang et al.   JOURNAL OF NEURO-ONCOLOGY

β-Actin specifically controls cell growth, migration, and the G-actin pool

(2011) Tina M. Bunnell et al.   MOLECULAR BIOLOGY OF THE CELL

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

(2011) Johannes M. Freudenberg et al.   NUCLEIC ACIDS RESEARCH

Reversible suppression of an essential gene in adult mice using transgenic RNA interference

(2011) K. McJunkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo

(2010) L. W. Hebbard et al.   CANCER RESEARCH

Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma

(2010) Nikolina Radulovich et al.   Molecular Cancer

Variability in gene expression underlies incomplete penetrance

(2010) Arjun Raj et al.   NATURE

The prion or the related Shadoo protein is required for early mouse embryogenesis

(2009) Rachel Young et al.   FEBS LETTERS

Cyclin D2 and the CDK substrate p220NPATare required for self-renewal of human embryonic stem cells

(2009) Klaus A. Becker et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Analysis of Nitric Oxide-Stabilized mRNAs in Human Fibroblasts Reveals HuR-Dependent Heme Oxygenase 1 Upregulation

(2009) Y. Kuwano et al.   MOLECULAR AND CELLULAR BIOLOGY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Sequence-non-specific effects of RNA interference triggers and microRNA regulators

(2009) Marta Olejniczak et al.   NUCLEIC ACIDS RESEARCH

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

(2009) S. E. Calvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

RNA-binding proteins and post-transcriptional gene regulation

(2008) Tina Glisovic et al.   FEBS LETTERS

RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology

(2008) Mohammad M. Ghahramani Seno et al.   HUMAN MOLECULAR GENETICS

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Antisense transcripts are targets for activating small RNAs

(2008) Jacob C Schwartz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conditional Repression of AUXIN BINDING PROTEIN1 Reveals That It Coordinates Cell Division and Cell Expansion during Postembryonic Shoot Development in Arabidopsis and Tobacco

(2008) N. Braun et al.   PLANT CELL

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA