In vivo glia‐to‐neuron conversion: pitfalls and solutions

Reprogramming cellular identity in vivo

(2022) Sydney Leaman et al.   DEVELOPMENT

Reply to In vivo confusion over in vivo conversion

(2022) Lei-Lei Wang et al.   MOLECULAR THERAPY

Limited astrocyte-to-neuron conversion in the mouse brain using NeuroD1 overexpression

(2022) David Leib et al.   MOLECULAR THERAPY

Lineage tracing: The gold standard to claim direct reprogramming in vivo

(2022) Clive N. Svendsen et al.   MOLECULAR THERAPY

A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum

(2022) Yunjia Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

(2021) Wenjiao Tai et al.   Cell Stem Cell

Neuronal replacement: Concepts, achievements, and call for caution

(2021) Magdalena Götz et al.   CURRENT OPINION IN NEUROBIOLOGY

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

(2021) Roy Maimon et al.   NATURE NEUROSCIENCE

Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy

(2021) Yu Tang et al.   Frontiers in Cell and Developmental Biology

cAAVe phaenomena: Beware of appearances!

(2021) Filippo Calzolari et al.   CELL

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

(2021) Célia Lentini et al.   Cell Stem Cell

NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming

(2021) Yanxia Rao et al.   NEURON

Neuroregenerative gene therapy to treat temporal lobe epilepsy in a rat model

(2021) Jiajun Zheng et al.   PROGRESS IN NEUROBIOLOGY

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors

(2021) Levi Todd et al.   Cell Reports

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

(2020) Zheng Wu et al.   Nature Communications

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Regeneration Through in vivo Cell Fate Reprogramming for Neural Repair

(2020) Wenjiao Tai et al.   Frontiers in Cellular Neuroscience

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Gene regulatory networks controlling vertebrate retinal regeneration

(2020) Thanh Hoang et al.   SCIENCE

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

(2019) Nicola Mattugini et al.   NEURON

Sources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectors

(2019) Kyle B. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live imaging of neurogenesis in the adult mouse hippocampus

(2018) Gregor-Alexander Pilz et al.   SCIENCE

New approaches for brain repair—from rescue to reprogramming

(2018) Roger A. Barker et al.   NATURE

Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain

(2018) Wenze Niu et al.   Stem Cell Reports

Stimulation of functional neuronal regeneration from Müller glia in adult mice

(2017) Nikolas L. Jorstad et al.   NATURE

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord

(2016) Lei-Lei Wang et al.   Cell Reports

Cre-Lox Neurogenetics: 20 Years of Versatile Applications in Brain Research and Counting…

(2016) Joe Z. Tsien   Frontiers in Genetics

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming

(2015) Mohammed M. Islam et al.   Stem Cell Reports

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

(2015) Wenze Niu et al.   Stem Cell Reports

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

(2013) Eric J. Benner et al.   NATURE

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain

(2011) Euiseok J. Kim et al.   PLoS One

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE