Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions

Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration

(2020) Xikun Han et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Polypyrimidine tract-binding proteins are essential for B cell development

(2020) Elisa Monzón-Casanova et al.   eLife

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

(2020) Eric Engelbrecht et al.   eLife

Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1

(2020) Michael S. Garshick et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit Inflammatory Signaling by Promoting Degradation of the p65 Subunit of NF-κB

(2020) Aya Jodo et al.   Frontiers in Immunology

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

(2020) Marie AC Depuydt et al.   CIRCULATION RESEARCH

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis

(2020) Ryoichi Nakamura et al.   Communications Biology

RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice

(2020) Denuja Karunakaran et al.   CIRCULATION

Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study

(2020) Aitor Andueza et al.   Cell Reports

Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations

(2019) Aditya S. Kalluri et al.   CIRCULATION

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

(2018) Athena Georgilis et al.   CANCER CELL

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers

(2018) Elisa Monzón-Casanova et al.   NATURE IMMUNOLOGY

CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing

(2018) Marinella G. Callow et al.   Cell Death & Disease

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

(2018) Patrick A Murphy et al.   eLife

Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation

(2018) Zaki Al-Yafeai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Platelets Guide Leukocytes to Their Sites of Extravasation

(2016) Gabriele Zuchtriegel et al.   PLOS BIOLOGY

A deletion atADAMTS9-MAGI1locus is associated with psoriatic arthritis risk

(2015) Antonio Julià et al.   ANNALS OF THE RHEUMATIC DISEASES

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

(2014) Sarah E Flanagan et al.   NATURE GENETICS

Lentiviral Delivery of RNAi for In Vivo Lineage-Specific Modulation of Gene Expression in Mouse Lung Macrophages

(2013) Andrew A Wilson et al.   MOLECULAR THERAPY

PTB Deficiency Causes the Loss of Adherens Junctions in the Dorsal Telencephalon and Leads to Lethal Hydrocephalus

(2012) Takayuki Shibasaki et al.   CEREBRAL CORTEX

Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation

(2010) Ryan E. Feaver et al.   CIRCULATION RESEARCH

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD

RIPK1 is not essential for TNFR1-induced activation of NF-κB

(2009) W W-L Wong et al.   CELL DEATH AND DIFFERENTIATION

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis

(2008) Ralph Gareus et al.   Cell Metabolism