Genetic Constructs for the Control of Astrocytes’ Activity

AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy

(2021) Simon J. O’Carroll et al.   Frontiers in Molecular Neuroscience

Prenatal ethanol exposure impairs the formation of radial glial fibers and promotes the transformation of GFAPδ‑positive radial glial cells into astrocytes

(2021) Yu Li et al.   Molecular Medicine Reports

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Optogenetic and chemogenetic modulation of astroglial secretory phenotype

(2021) Alla B. Salmina et al.   REVIEWS IN THE NEUROSCIENCES

Characterization of Subcellular Organelles in Cortical Perisynaptic Astrocytes

(2021) Amina Aboufares El Alaoui et al.   Frontiers in Cellular Neuroscience

Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

(2021) Pranav Preman et al.   Cells

The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model

(2021) Nicole J. Sylvain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

(2021) Mootaz M. Salman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

(2021) John K. Mich et al.   Cell Reports

Astrocyte Diversity: Current Insights and Future Directions

(2020) Thomas Westergard et al.   NEUROCHEMICAL RESEARCH

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

(2020) Philip Kitchen et al.   CELL

Stem cells and vascular dementia: from basic science to the clinic

(2020) Wenxia Jiang et al.   CELL AND TISSUE BANKING

AAV Capsid-Promoter Interactions Determine CNS Cell-Selective Gene Expression In Vivo

(2020) Sara K. Powell et al.   MOLECULAR THERAPY

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes

(2020) Kaiyang Ma et al.   NEUROPHARMACOLOGY

Activation of a neural stem cell transcriptional program in parenchymal astrocytes

(2020) Jens P Magnusson et al.   eLife

Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives

(2020) Joana Martins‐Macedo et al.   GLIA

Dissecting Neuronal Activation on a Brain-Wide Scale With Immediate Early Genes

(2020) Alessandra Franceschini et al.   Frontiers in Neuroscience

Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging

(2020) Mootaz M. Salman et al.   Frontiers in Bioengineering and Biotechnology

Crossing the blood-brain barrier with AAV vectors

(2020) Dan Liu et al.   METABOLIC BRAIN DISEASE

The Paradox of Astroglial Ca2 + Signals at the Interface of Excitation and Inhibition

(2020) Laura C. Caudal et al.   Frontiers in Cellular Neuroscience

Melanopsin for precise optogenetic activation of astrocyte-neuron networks

(2019) Sara Mederos et al.   GLIA

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

(2019) Jarred M. Griffin et al.   GENE THERAPY

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

(2019) Anna B. Toth et al.   Science Signaling

The energetic brain ‐ A review from students to students

(2019) M.P. Bordone et al.   JOURNAL OF NEUROCHEMISTRY

The Appropriate Marker for Astrocytes: Comparing the Distribution and Expression of Three Astrocytic Markers in Different Mouse Cerebral Regions

(2019) Zengli Zhang et al.   Biomed Research International

Astroglial atrophy in Alzheimer’s disease

(2019) Alexei Verkhratsky et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Development of Efficient AAV2/DJ-Based Viral Vectors to Selectively Downregulate the Expression of Neuronal or Astrocytic Target Proteins in the Rat Central Nervous System

(2019) Charlotte Jollé et al.   Frontiers in Molecular Neuroscience

Astrocytes: Role and Functions in Brain Pathologies

(2019) Rosalba Siracusa et al.   Frontiers in Pharmacology

Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior

(2019) Michael Tri H. Do   NEURON

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

(2019) Qin Huang et al.   PLoS One

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

(2019) Tanja Hyvärinen et al.   Scientific Reports

Expression Patterns of Inducible Cre Recombinase Driven by Differential Astrocyte-Specific Promoters in Transgenic Mouse Lines

(2019) Neng-Yuan Hu et al.   Neuroscience Bulletin

Cerebral Organoids Repair Ischemic Stroke Brain Injury

(2019) Shu-Na Wang et al.   Translational Stroke Research

Viral Strategies for Targeting the Central and Peripheral Nervous Systems

(2018) Claire N. Bedbrook et al.   Annual Review of Neuroscience

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer’s Disease Adults

(2018) Sara Cipriani et al.   CEREBRAL CORTEX

Marked Diversity of Unique Cortical Enhancers Enables Neuron-Specific Tools by Enhancer-Driven Gene Expression

(2018) Stefan Blankvoort et al.   CURRENT BIOLOGY

The cysteine residue of glial fibrillary acidic protein is a critical target for lipoxidation and required for efficient network organization

(2018) Álvaro Viedma-Poyatos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions

(2018) Todd A. Fiacco et al.   JOURNAL OF NEUROSCIENCE

Gliotransmitters and cytokines in the control of blood-brain barrier permeability

(2018) Elena D. Osipova et al.   REVIEWS IN THE NEUROSCIENCES

Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior

(2018) Sónia Guerra-Gomes et al.   Frontiers in Cellular Neuroscience

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

(2018) Ana Covelo et al.   eLife

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

(2018) Nina Vardjan et al.   Frontiers in Molecular Neuroscience

Expression of radial glial markers (GFAP, BLBP and GS) during telencephalic development in the catshark (Scyliorhinus canicula)

(2018) A. Docampo-Seara et al.   Brain Structure & Function

Astrocyte Heterogeneity in the Adult Central Nervous System

(2018) Sean J. Miller   Frontiers in Cellular Neuroscience

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Chloride conducting light activated channel GtACR2 can produce both cessation of firing and generation of action potentials in cortical neurons in response to light

(2017) A.Y. Malyshev et al.   NEUROSCIENCE LETTERS

Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection

(2017) Sean L. Hammond et al.   PLoS One

Blood-brain barrier-supported neurogenesis in healthy and diseased brain

(2017) Elena A. Pozhilenkova et al.   REVIEWS IN THE NEUROSCIENCES

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

(2017) Zhibing Tan et al.   Nature Communications

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC 1 D-Driven Transgene Expression in AAV-Mediated Gene Transfer

(2017) Grit Taschenberger et al.   Molecular Therapy-Nucleic Acids

AAV-Mediated Astrocyte-Specific Gene Expression under Human ALDH1L1 Promoter in Mouse Thalamus

(2017) Wuhyun Koh et al.   Experimental Neurobiology

RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?

(2017) Shi Du Yan et al.   JOURNAL OF ALZHEIMERS DISEASE

Systemic application of AAV vectors targeting GFAP-expressing astrocytes in Z -Q175-KI Huntington's disease mice

(2016) Tatyana Vagner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains

(2016) Yoichiro Shinohara et al.   PLoS One

Astrocytes regulate heterogeneity of presynaptic strengths in hippocampal networks

(2016) Mathieu Letellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant Adeno-Associated Virus Serotype 6 (rAAV6) Potently and Preferentially Transduces Rat Astrocytes In vitro and In vivo

(2016) Alexandra L. Schober et al.   Frontiers in Cellular Neuroscience

Transcriptional activity of novel ALDH1L1 promoters in the rat brain following AAV vector-mediated gene transfer

(2016) Janitha M Mudannayake et al.   Molecular Therapy-Methods & Clinical Development

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

(2015) Willem Kamphuis et al.   GLIA

Glycolysis-mediated control of blood-brain barrier development and function

(2015) Alla B. Salmina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Specific gene expression in mouse cortical astrocytes is mediated by a 1740bp-GFAP promoter-driven combined adeno-associated virus2/5/7/8/9

(2015) Xiandong Meng et al.   NEUROSCIENCE LETTERS

Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex

(2015) Akiya Watakabe et al.   NEUROSCIENCE RESEARCH

Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

(2015) Zhihui Yang et al.   TRENDS IN NEUROSCIENCES

A Novel Subtype of Astrocytes Expressing TRPV4 (Transient Receptor Potential Vanilloid 4) Regulates Neuronal Excitability via Release of Gliotransmitters

(2014) Koji Shibasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network

(2014) Regina Kanski et al.   JOURNAL OF CELL SCIENCE

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

(2014) Ricardo Cabezas et al.   Frontiers in Cellular Neuroscience

Altered expression of Alzheimer’s disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy

(2014) F Zeidán-Chuliá et al.   Cell Death & Disease

Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons

(2014) Jun-Hyeok Choi et al.   Molecular Brain

Potassium Buffering in the Neurovascular Unit: Models and Sensitivity Analysis

(2013) Alexandra Witthoft et al.   BIOPHYSICAL JOURNAL

Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes

(2013) Georg Andreas Gundersen et al.   Brain Structure & Function

Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type–Specific Transgene Expression in the Spinal Cord

(2013) Elisabeth Dirren et al.   HUMAN GENE THERAPY

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses

(2013) Eiji Shigetomi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

(2013) Willem Kamphuis et al.   NEUROBIOLOGY OF AGING

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain

(2013) Paramita Chakrabarty et al.   PLoS One

Glial Promoter Selectivity following AAV-Delivery to the Immature Brain

(2013) Georg von Jonquieres et al.   PLoS One

Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain

(2013) Dominik F. Aschauer et al.   PLoS One

Correction: Alternative mRNA Splicing from the Glial Fibrillary Acidic Protein (GFAP) Gene Generates Isoforms with Distinct Subcellular mRNA Localization Patterns in Astrocytes

(2013) Rune Thomsen et al.   PLoS One

The Evolutionary Relationship between Microbial Rhodopsins and Metazoan Rhodopsins

(2013) Libing Shen et al.   TheScientificWorldJOURNAL

Heterosynaptic long-term depression mediated by ATP released from astrocytes

(2012) Jiadong Chen et al.   GLIA

GFAPδ Expression in Glia of the Developmental and Adolescent Mouse Brain

(2012) Carlyn Mamber et al.   PLoS One

The Microbial Opsin Family of Optogenetic Tools

(2011) Feng Zhang et al.   CELL

Adenosine kinase as a target for therapeutic antisense strategies in epilepsy

(2011) Panos Theofilas et al.   EPILEPSIA

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Structural Remodeling of Astrocytes in the Injured CNS

(2011) Daniel Sun et al.   NEUROSCIENTIST

S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

(2011) Jie Lu et al.   PLoS One

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Shedding new light on opsin evolution

(2011) M. L. Porter et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ca2+ sources for the exocytotic release of glutamate from astrocytes

(2010) Vladimir Parpura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transduction

(2010) Y. Xie et al.   NEUROSCIENCE

GFAPδ in radial glia and subventricular zone progenitors in the developing human cortex

(2009) Jinte Middeldorp et al.   DEVELOPMENT

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+levels

(2009) Lasse K. Bak et al.   JOURNAL OF NEUROCHEMISTRY

Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates

(2009) Patricia A Lawlor et al.   MOLECULAR THERAPY

Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery

(2009) James T Koerber et al.   MOLECULAR THERAPY

Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood–Brain Barrier (BBB)

(2009) Steven J Gray et al.   MOLECULAR THERAPY

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

ARG3.1/ARC expression in hippocampal dentate gyrus astrocytes: ultrastructural evidence and co-localization with glial fibrillary acidic protein

(2008) J. J. Rodríguez et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glutamate activates GFAP gene promoter from cultured astrocytes through TGF-1 pathways

(2008) Luciana Ferreira Romo et al.   JOURNAL OF NEUROCHEMISTRY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method

(2007) Ronald L Klein et al.   MOLECULAR THERAPY

Tropism and toxicity of adeno-associated viral vector serotypes 1, 2, 5, 6, 7, 8, and 9 in rat neurons and glia in vitro

(2007) Douglas B. Howard et al.   VIROLOGY