Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

Limited astrocyte-to-neuron conversion in the mouse brain using NeuroD1 overexpression

(2022) David Leib et al.   MOLECULAR THERAPY

A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum

(2022) Yunjia Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting PTB as a One-Step Procedure for In Situ Astrocyte-to-Dopamine Neuron Reprogramming in Parkinson’s Disease

(2021) Yuanyuan Jiang et al.   Neuroscience Bulletin

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

(2021) Roy Maimon et al.   NATURE NEUROSCIENCE

AAV ablates neurogenesis in the adult murine hippocampus

(2021) Stephen Johnston et al.   eLife

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

(2021) Célia Lentini et al.   Cell Stem Cell

Neuroregenerative gene therapy to treat temporal lobe epilepsy in a rat model

(2021) Jiajun Zheng et al.   PROGRESS IN NEUROBIOLOGY

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

(2020) Zheng Wu et al.   Nature Communications

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

NeuroD1 overexpression in spinal neurons accelerates axonal regeneration after sciatic nerve injury

(2020) Muhua Lai et al.   EXPERIMENTAL NEUROLOGY

Method to combat Parkinson’s disease by astrocyte-to-neuron conversion

(2020) Ernest Arenas   NATURE

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging

(2020) Young-Kyoung Ryu et al.   NEUROPHARMACOLOGY

In vivo glial trans‐differentiation for neuronal replacement and functional recovery in central nervous system

(2020) Cheng Qian et al.   FEBS Journal

Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling

(2020) Germán Belenguer et al.   Cell Stem Cell

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

(2019) Nicola Mattugini et al.   NEURON

Early activation of Egr-1 promotes neuroinflammation and dopaminergic neurodegeneration in an experimental model of Parkinson's disease

(2018) Qing Yu et al.   EXPERIMENTAL NEUROLOGY

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Jun/Bim Upregulation in Dopaminergic Neurons Promotes Neurodegeneration in the MPTP Mouse Model of Parkinson’s Disease

(2018) Kunhua Hu et al.   NEUROSCIENCE

Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons

(2017) Marc S. Weinberg et al.   MOLECULAR THERAPY

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

(2017) Rebecca Brulet et al.   Stem Cell Reports

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord

(2016) Lei-Lei Wang et al.   Cell Reports

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

(2015) Wenze Niu et al.   Stem Cell Reports

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Retinal Injury, Growth Factors, and Cytokines Converge on β-Catenin and pStat3 Signaling to Stimulate Retina Regeneration

(2014) Jin Wan et al.   Cell Reports

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

(2013) Swetlana Sirko et al.   Cell Stem Cell

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Lineage Tracing

(2012) Kai Kretzschmar et al.   CELL

Self-Renewal and Differentiation of Reactive Astrocyte-Derived Neural Stem/Progenitor Cells Isolated from the Cortical Peri-Infarct Area after Stroke

(2012) I. S. Shimada et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects

(2012) Soheila Karimi-Abdolrezaee et al.   MOLECULAR NEUROBIOLOGY

The stem cell potential of glia: lessons from reactive gliosis

(2011) Stefanie Robel et al.   NATURE REVIEWS NEUROSCIENCE

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

(2010) Keigan M. Park et al.   CELLULAR SIGNALLING

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA