Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

(2021) Álvaro Herrero-Navarro et al.   Science Advances

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons

(2020) Ayelén I. Groisman et al.   Cell Reports

Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options

(2020) Wolfgang Löscher et al.   PHARMACOLOGICAL REVIEWS

Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

(2020) Shane A. Liddelow et al.   TRENDS IN IMMUNOLOGY

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

Direct Lineage Reprogramming for Brain Repair: Breakthroughs and Challenges

(2019) Rory Vignoles et al.   TRENDS IN MOLECULAR MEDICINE

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

(2019) Nicola Mattugini et al.   NEURON

Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons

(2019) Susan Lindtner et al.   Cell Reports

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way

(2018) Ira Espuny-Camacho et al.   Cell Reports

New approaches for brain repair—from rescue to reprogramming

(2018) Roger A. Barker et al.   NATURE

Pyramidal cell regulation of interneuron survival sculpts cortical networks

(2018) Fong Kuan Wong et al.   NATURE

Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity

(2018) Alexandru Cǎlin et al.   Frontiers in Cellular Neuroscience

Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits

(2018) Qi-Gang Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and Functional Diversification of Cortical Interneurons

(2018) Lynette Lim et al.   NEURON

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

(2018) Dinesh Upadhya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice

(2017) Meinrad Drexel et al.   JOURNAL OF NEUROSCIENCE

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

DREADDS: Use and application in behavioral neuroscience.

(2016) Kyle S. Smith et al.   BEHAVIORAL NEUROSCIENCE

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Synaptic Remodeling of Entorhinal Input Contributes to an Aberrant Hippocampal Network in Temporal Lobe Epilepsy

(2016) Philipp Janz et al.   CEREBRAL CORTEX

Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy

(2016) Venceslas Duveau et al.   CNS Neuroscience & Therapeutics

Activation of GABA A receptors controls mesiotemporal lobe epilepsy despite changes in chloride transporters expression: In vivo and in silico approach

(2016) Séverine Stamboulian-Platel et al.   EXPERIMENTAL NEUROLOGY

Transplanted embryonic neurons integrate into adult neocortical circuits

(2016) Susanne Falkner et al.   NATURE

A disynaptic feedback network activated by experience promotes the integration of new granule cells

(2016) D. D. Alvarez et al.   SCIENCE

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis

(2015) Amanda Sierra et al.   Cell Stem Cell

NG2-glia and their functions in the central nervous system

(2015) L. Dimou et al.   GLIA

In vivo reprogramming for tissue repair

(2015) Christophe Heinrich et al.   NATURE CELL BIOLOGY

A Critical Period for Experience-Dependent Remodeling of Adult-Born Neuron Connectivity

(2015) Matteo Bergami et al.   NEURON

Area-Specific Reestablishment of Damaged Circuits in the Adult Cerebral Cortex by Cortical Neurons Derived from Mouse Embryonic Stem Cells

(2015) Kimmo A. Michelsen et al.   NEURON

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

Epilepsies associated with hippocampal sclerosis

(2014) Fernando Cendes et al.   ACTA NEUROPATHOLOGICA

hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizures and Abnormal Behavior in Epileptic Mice

(2014) Miles Cunningham et al.   Cell Stem Cell

Long-Term Seizure Suppression and Optogenetic Analyses of Synaptic Connectivity in Epileptic Mice with Hippocampal Grafts of GABAergic Interneurons

(2014) K. W. Henderson et al.   JOURNAL OF NEUROSCIENCE

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods

(2013) Ingmar Blümcke et al.   EPILEPSIA

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents

(2013) A. I. Wlodarczyk et al.   JOURNAL OF NEUROSCIENCE

The international consensus classification for hippocampal sclerosis: an important step towards accurate prognosis

(2013) Ingmar Blumcke et al.   LANCET NEUROLOGY

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior

(2013) Robert F Hunt et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb

(2013) A. Deshpande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy

(2011) Fabien Pernot et al.   EPILEPSIA

A Novel Functionally Distinct Subtype of Striatal Neuropeptide Y Interneuron

(2011) O. Ibanez-Sandoval et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity is required for the development of specific cortical interneuron subtypes

(2011) Natalia V. De Marco García et al.   NATURE

Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex

(2011) Christophe Heinrich et al.   Nature Protocols

Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy

(2011) Christophe Heinrich et al.   NEUROBIOLOGY OF DISEASE

Loss and reorganization of calretinin-containing interneurons in the epileptic human hippocampus

(2010) K. Toth et al.   BRAIN

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

An Embedded Subnetwork of Highly Active Neurons in the Neocortex

(2010) Lina Yassin et al.   NEURON

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

Exogenous reelin prevents granule cell dispersion in experimental epilepsy

(2009) Martin C. Müller et al.   EXPERIMENTAL NEUROLOGY

Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice

(2009) S. C. Baraban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granule cell dispersion develops without neurogenesis and does not fully depend on astroglial cell generation in a mouse model of temporal lobe epilepsy

(2008) Naoki Nitta et al.   EPILEPSIA

The Basic Helix-Loop-Helix Transcription Factor Olig2 Is Critical for Reactive Astrocyte Proliferation after Cortical Injury

(2008) Y. Chen et al.   JOURNAL OF NEUROSCIENCE