BCAA dysmetabolism in the host and gut microbiome, a key player in the development of obesity and T2DM

The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology

(2022) Aikaterini Dimou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity

(2022) Ming Liu et al.   Metabolites

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

(2022) Froukje Vanweert et al.   Nature Communications

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

(2022) Thomas Grenier-Larouche et al.   JCI Insight

The Role of Branched-Chain Amino Acids and Branched-Chain α-Keto Acid Dehydrogenase Kinase in Metabolic Disorders

(2022) Chuang Du et al.   Frontiers in Nutrition

Branched-chain amino acids in cardiovascular disease

(2022) Robert W. McGarrah et al.   Nature Reviews Cardiology

Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese

(2021) Weiqi Wang et al.   Genes and Nutrition

Multiomics Approach to Explore the Amelioration Mechanisms of Glucomannans on the Metabolic Disorder of Type 2 Diabetic Rats

(2021) Haihong Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

(2021) Deyang Yu et al.   Cell Metabolism

BCAA Supplementation in Mice with Diet-Induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis

(2021) Jennifer Lee et al.   ENDOCRINOLOGY

Activation of GCN2 in macrophages promotes white adipose tissue browning and lipolysis under leucine deprivation

(2021) Fenfen Wang et al.   FASEB JOURNAL

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

(2021) Xin Zhang et al.   Cell Reports

Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model

(2021) Tiffany M. Newman et al.   Microbiome

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

(2021) Rasmus J. O. Sjögren et al.   DIABETOLOGIA

Energy metabolism in brown adipose tissue

(2021) Zhichao Wang et al.   FEBS Journal

BCKDK: an emerging kinase target for metabolic diseases and cancer

(2021) Michael P. East et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Skeletal Muscle in The Pathogenesis of Altered Concentrations of Branched-Chain Amino Acids (Valine, Leucine, and Isoleucine) in Liver Cirrhosis, Diabetes, and Other Diseases

(2021) M Holeček   PHYSIOLOGICAL RESEARCH

Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice

(2021) Béatrice S.-Y. Choi et al.   Nature Communications

SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

(2021) Elma Zaganjor et al.   Cell Reports

Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism

(2021) Gagandeep Mann et al.   Frontiers in Physiology

Association of Plasma Branched-Chain Amino Acid With Biomarkers of Inflammation and Lipid Metabolism in Women

(2021) Rikuta Hamaya et al.   Circulation-Genomic and Precision Medicine

Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression

(2021) Hanrui Yin et al.   DIABETES

Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus

(2021) Shuyun Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice

(2021) Eri Wada et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

(2021) Phillip J. White et al.   Molecular Metabolism

Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance

(2021) Jan Gojda et al.   Biomolecules

Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

(2021) Naofumi Yoshida et al.   iScience

Amino Acids Regulate Glycolipid Metabolism and Alter Intestinal Microbial Composition..

(2020) Fei Xie et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Energy metabolism profile of the effects of amino acid treatment on skeletal muscle cells: Leucine inhibits glycolysis of myotubes

(2020) Reiko Suzuki et al.   NUTRITION

Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism

(2020) Su-Ling Zeng et al.   Science Advances

Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

(2020) Huishou Zhao et al.   DIABETES

Branched Chain Amino Acid Catabolism by Brown Adipose Tissue

(2020) André C Carpentier   ENDOCRINOLOGY

Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent

(2020) Guillaume Grzych et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

3-Hydroxyisobutyrate, a Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism

(2020) Mona S. Nilsen et al.   DIABETES

Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscle

(2020) Cristina Sánchez‐González et al.   EMBO JOURNAL

The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism

(2020) Christopher A. Bishop et al.   FASEB JOURNAL

Dietary Luffa cylindrica (L.) Roem promotes branched-chain amino acid catabolism in the circulation system via gut microbiota in diet-induced obese mice

(2020) Lu Zhang et al.   FOOD CHEMISTRY

Daily Branched‐Chain Amino Acid Intake and Risks of Obesity and Insulin Resistance in Children: A Cross‐Sectional Study

(2020) Jun Lu et al.   Obesity

Exploring mechanistic links between extracellular BCAA & muscle insulin resistance: an in vitro approach

(2020) Hannah Crossland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Branched-chain ketoacid overload inhibits insulin action in the muscle

(2020) Dipsikha Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fasting status and metabolic health in relation to plasma branched chain amino acid concentrations in women

(2020) Deirdre K. Tobias et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population

(2020) Samuel H Gunther et al.   BMJ Open Diabetes Research & Care

Gut microbiota-derived metabolites as central regulators in metabolic disorders

(2020) Allison Agus et al.   GUT

Potential Roles of Exercise-Induced Plasma Metabolites Linking Exercise to Health Benefits

(2020) Yong Ryoul Yang et al.   Frontiers in Physiology

Valine Supplementation Does Not Reduce Lipid Accumulation and Improve Insulin Sensitivity in Mice Fed High-Fat Diet

(2020) Qingquan Ma et al.   ACS Omega

Bariatric surgery reduces branched-chain amino acids’ levels: a systematic review and meta-analysis

(2020) Reza Barati-Boldaji et al.   NUTRITION RESEARCH

Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids

(2019) Eline van den Berg et al.   Nutrients

Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism

(2019) Dmitrii Tanianskii et al.   Nutrients

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

(2019) Meiyi Zhou et al.   DIABETES

Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats

(2019) Carmen D Tekwe et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice

(2019) Ji Wang et al.   Frontiers in Physiology

Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans

(2019) Jan Stautemas et al.   Frontiers in Physiology

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

BCAA Metabolism and Insulin Sensitivity - Dysregulated by Metabolic Status?

(2018) Nicholas P. Gannon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

(2018) Adil Mardinoglu et al.   EBioMedicine

Branched Chain Amino Acids in Metabolic Disease

(2018) Zoltan Arany et al.   Current Diabetes Reports

Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation

(2018) Olha Zhenyukh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Brown Adipose Tissue Energy Metabolism in Humans

(2018) André C. Carpentier et al.   Frontiers in Endocrinology

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

(2018) Michael D. Neinast et al.   Cell Metabolism

PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues

(2018) Pierre-Gilles Blanchard et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

(2018) Martina Wallace et al.   Nature Chemical Biology

Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients

(2017) Colette Shortt et al.   EUROPEAN JOURNAL OF NUTRITION

Liver BCATm transgenic mouse model reveals the important role of the liver in maintaining BCAA homeostasis

(2017) Elitsa A. Ananieva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Restoration of metabolic health by decreased consumption of branched-chain amino acids

(2017) Nicole E. Cummings et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

FFA4/GPR120: Pharmacology and Therapeutic Opportunities

(2017) Graeme Milligan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

(2017) Adonia E. Papathanassiu et al.   Nature Communications

Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner

(2016) Yoshinaga Kawano et al.   Cell Metabolism

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition

(2016) Isabel Arrieta-Cruz et al.   Nutrients

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

(2016) Carles Lerin et al.   Molecular Metabolism

Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes

(2016) Emilia Heimann et al.   Adipocyte

Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease

(2015) Nishanth E. Sunny et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine-induced anabolic-catabolism: two sides of the same coin

(2015) Nicholas P. Gannon et al.   AMINO ACIDS

l-Leucine and NO-mediated cardiovascular function

(2015) Ying Yang et al.   AMINO ACIDS

β-Hydroxy-β-methylbutyrate, mitochondrial biogenesis, and skeletal muscle health

(2015) Xi He et al.   AMINO ACIDS

Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes

(2015) Pieter Giesbertz et al.   DIABETOLOGIA

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

(2015) Courtney R Green et al.   Nature Chemical Biology

Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission

(2015) Tulika Arora et al.   PLoS One

Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes

(2015) Scott B. Crown et al.   PLoS One

Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism

(2014) Andrew C. Shin et al.   Cell Metabolism

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders

(2014) Lindsay C. Burrage et al.   MOLECULAR GENETICS AND METABOLISM

Leucine alters hepatic glucose/lipid homeostasis via the myostatin-AMP-activated protein kinase pathway - potential implications for nonalcoholic fatty liver disease

(2014) Aida Zarfeshani et al.   Clinical Epigenetics

Impact of nutrient excess and endothelial nitric oxide synthase on the plasma metabolite profile in mice

(2014) Brian E. Sansbury et al.   Frontiers in Physiology

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

(2013) Denise E. Lackey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells

(2013) Roger A. Vaughan et al.   AMINO ACIDS

Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach

(2013) C. Menni et al.   DIABETES

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

Tissue-specific and Nutrient Regulation of the Branched-chain α-Keto Acid Dehydrogenase Phosphatase, Protein Phosphatase 2Cm (PP2Cm)

(2012) Meiyi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thiazolidinediones and PPARγ agonists: time for a reassessment

(2012) Bertrand Cariou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT

(2011) Ying Du et al.   AMINO ACIDS

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes

(2011) Marika Leenders et al.   NUTRITION REVIEWS

Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ

(2011) William T. Festuccia et al.   Frontiers in Endocrinology

Utilization of amino acids by bacteria from the pig small intestine

(2010) Zhao-Lai Dai et al.   AMINO ACIDS

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

Amino acid metabolism in intestinal bacteria: links between gut ecology and host health

(2010) Zhao-Lai Dai   Frontiers in Bioscience-Landmark

Catabolism of nutritionally essential amino acids in developing porcine enterocytes

(2009) Lixiang Chen et al.   AMINO ACIDS

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Overexpression of GPR40 in Pancreatic  -Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

(2009) K. Nagasumi et al.   DIABETES

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue

(2009) Y. Cheng et al.   DIABETES

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY