Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice

Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

(2020) Huishou Zhao et al.   DIABETES

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet

(2020) Joely A. Kellard et al.   Molecular Metabolism

ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity

(2020) Ebrahim H. Ghazvini Zadeh et al.   Cell Reports

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

(2019) Meiyi Zhou et al.   DIABETES

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

(2019) Elizabeth Haythorne et al.   Nature Communications

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

α-cell glucokinase suppresses glucose-regulated glucagon secretion

(2018) Davide Basco et al.   Nature Communications

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

(2018) Ankit X. Sharma et al.   Cell Reports

Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review

(2018) Henver S. Brunetta et al.   AMINO ACIDS

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

(2018) Sho Matsui et al.   Nature Communications

SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels

(2018) Takayoshi Suga et al.   Molecular Metabolism

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion

(2017) Nadejda Bozadjieva et al.   JOURNAL OF CLINICAL INVESTIGATION

Restoration of metabolic health by decreased consumption of branched-chain amino acids

(2017) Nicole E. Cummings et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus

(2016) D. J. Kazierad et al.   DIABETES OBESITY & METABOLISM

Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness

(2016) Daisuke Kohno et al.   Frontiers in Neuroscience

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

(2015) Christof M. Kazda et al.   DIABETES CARE

Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion

(2015) Jia Li et al.   FASEB JOURNAL

Islet α cells and glucagon—critical regulators of energy homeostasis

(2015) Jonathan E. Campbell et al.   Nature Reviews Endocrinology

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

(2015) Mark J. Solloway et al.   Cell Reports

Branched-chain amino acids supplementation protects streptozotocin-induced insulin secretion and the correlated mechanism

(2014) Ming Lu et al.   BIOFACTORS

Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?

(2014) Nicolai J. Wewer Albrechtsen et al.   DIABETOLOGIA

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes

(2014) Laura Marroquí et al.   NUTRITION RESEARCH REVIEWS

The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice

(2011) Mie Arakawa et al.   ENDOCRINE JOURNAL

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Amino acid ingestion and glucose metabolism-A review

(2010) Mary C. Gannon et al.   IUBMB LIFE

Transamination Is Required for α-Ketoisocaproate but Not Leucine to Stimulate Insulin Secretion

(2010) Yingsheng Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unperturbed islet α-cell function examined in mouse pancreas tissue slices

(2010) Ya-Chi Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice

(2010) Aidan S. Hancock et al.   MOLECULAR ENDOCRINOLOGY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE