The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

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Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

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FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

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Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial

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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

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Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms

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Branched Chain Amino Acids Are Associated with Insulin Resistance Independent of Leptin and Adiponectin in Subjects with Varying Degrees of Glucose Tolerance

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Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

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Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans

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Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism

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A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

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A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

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Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

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Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

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Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

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Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort

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Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

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Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice

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The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

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Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

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The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo

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Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

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Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

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Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

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A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice

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Isoleucine and Leucine Independently Regulate mTOR Signaling and Protein Synthesis in MAC-T Cells and Bovine Mammary Tissue Slices

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo

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Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

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FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

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Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

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