BCAA Metabolism and Insulin Sensitivity - Dysregulated by Metabolic Status?
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
BCAA Metabolism and Insulin Sensitivity - Dysregulated by Metabolic Status?
Authors
Keywords
-
Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 62, Issue 6, Pages 1700756
Publisher
Wiley
Online
2018-01-30
DOI
10.1002/mnfr.201700756
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- International Society of Sports Nutrition Position Stand: protein and exercise
- (2017) Ralf Jäger et al. Journal of the International Society of Sports Nutrition
- International society of sports nutrition position stand: diets and body composition
- (2017) Alan A. Aragon et al. Journal of the International Society of Sports Nutrition
- Leucine Supplementation Differently Modulates Branched-Chain Amino Acid Catabolism, Mitochondrial Function and Metabolic Profiles at the Different Stage of Insulin Resistance in Rats on High-Fat Diet
- (2017) et al. Nutrients
- Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner
- (2016) Mahshid Moghei et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Determination of the safety of leucine supplementation in healthy elderly men
- (2016) Betina Rasmussen et al. AMINO ACIDS
- Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis and oxidative metabolism with enhanced GLUT4 content and glucose uptake in myotubes
- (2016) Jamie K. Schnuck et al. BIOCHIMIE
- Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view
- (2016) Francesco Bifari et al. BRITISH JOURNAL OF PHARMACOLOGY
- Branched-Chain Amino Acids and Insulin Metabolism: The Insulin Resistance Atherosclerosis Study (IRAS)
- (2016) C. Christine Lee et al. DIABETES CARE
- Metabolic Fate of Branched-Chain Amino Acids During Adipogenesis, in Adipocytes From Obese Mice and C2C12 Myotubes
- (2016) Isabela Estrada-Alcalde et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans
- (2016) Jheelam Banerjee et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
- (2016) Cholsoon Jang et al. NATURE MEDICINE
- Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance
- (2016) Chisa Takashina et al. Nutrition & Metabolism
- Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition
- (2016) Isabel Arrieta-Cruz et al. Nutrients
- Defining meal requirements for protein to optimize metabolic roles of amino acids
- (2015) Donald K Layman et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk
- (2015) Marie Michèle Boulet et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Leucine-induced anabolic-catabolism: two sides of the same coin
- (2015) Nicholas P. Gannon et al. AMINO ACIDS
- Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice
- (2015) José M. Costa Júnior et al. AMINO ACIDS
- Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
- (2015) Therese Tillin et al. DIABETOLOGIA
- Supplemental Protein in Support of Muscle Mass and Health: Advantage Whey
- (2015) Michaela C. Devries et al. JOURNAL OF FOOD SCIENCE
- Whey Protein Supplementation Does Not Alter Plasma Branched-Chained Amino Acid Profiles but Results in Unique Metabolomics Patterns in Obese Women Enrolled in an 8-Week Weight Loss Trial
- (2015) Brian D Piccolo et al. JOURNAL OF NUTRITION
- 18-Carbon polyunsaturated fatty acids ameliorate palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes
- (2015) Pei-Yin Chen et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice
- (2015) Lizhi Fu et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives
- (2015) Venkateswarlu Korthikunta et al. PHYTOMEDICINE
- Association between insulin resistance and plasma amino acid profile in non-diabetic Japanese subjects
- (2015) Chizumi Yamada et al. Journal of Diabetes Investigation
- 4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway
- (2014) Arun Kumar Rawat et al. FITOTERAPIA
- 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells
- (2014) Chandan Kumar Maurya et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini-review
- (2014) Nicholas P. Gannon et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Branched-chain amino acids in metabolic signalling and insulin resistance
- (2014) Christopher J. Lynch et al. Nature Reviews Endocrinology
- Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells
- (2014) José L. Areta et al. NUTRITION RESEARCH
- PGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle
- (2014) Yukino Hatazawa et al. PLoS One
- Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity
- (2013) Denise E. Lackey et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells
- (2013) Roger A. Vaughan et al. AMINO ACIDS
- A dipeptide and an amino acid present in whey protein hydrolysate increase translocation of GLUT-4 to the plasma membrane in Wistar rats
- (2013) P.N. Morato et al. FOOD CHEMISTRY
- Regulation of mTORC1 and its impact on gene expression at a glance
- (2013) M. Laplante et al. JOURNAL OF CELL SCIENCE
- Dietary stimulators of the PGC-1 superfamily and mitochondrial biosynthesis in skeletal muscle. A mini-review
- (2013) Roger A. Vaughan et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Whey Protein Supplementation During Resistance Training Augments Lean Body Mass
- (2013) Jeff S. Volek et al. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
- Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3
- (2013) Julia Brenmoehl et al. MITOCHONDRION
- Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues
- (2013) Xiang Li et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels
- (2013) Elke Binder et al. PLoS One
- Determination of the tolerable upper intake level of leucine in acute dietary studies in young men
- (2012) Rajavel Elango et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Leucine and mTORC1: a complex relationship
- (2012) Kayleigh M. Dodd et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
- (2012) Hongliang Li et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance
- (2012) Christopher B. Newgard Cell Metabolism
- Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein
- (2012) Shanon L. Casperson et al. CLINICAL NUTRITION
- Metabolic Signatures of Insulin Resistance in 7,098 Young Adults
- (2012) P. Wurtz et al. DIABETES
- 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway
- (2012) Natasha Jaiswal et al. EUROPEAN JOURNAL OF NUTRITION
- PGC-1α and exercise in the control of body weight
- (2012) S Summermatter et al. INTERNATIONAL JOURNAL OF OBESITY
- Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion
- (2012) Pierre-Gilles Blanchard et al. JOURNAL OF LIPID RESEARCH
- A Proposal for an Upper Limit of Leucine Safe Intake in Healthy Adults
- (2012) Luc Cynober et al. JOURNAL OF NUTRITION
- Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels
- (2012) Astrid Haegens et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
- (2012) Antje Bruckbauer et al. Nutrition & Metabolism
- Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways
- (2012) Agus Suryawan et al. PEDIATRIC RESEARCH
- PGC-1 coactivators in the control of energy metabolism
- (2011) C. Liu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis
- (2011) S. M. Pasiakos et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- An amino acid mixture improves glucose tolerance and insulin signaling in Sprague-Dawley rats
- (2011) Jeffrey R. Bernard et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Leucine-stimulated mTOR signaling is partly attenuated in skeletal muscle of chronically uremic rats
- (2011) Yu Chen et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity
- (2011) Serge Summermatter et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hypothalamic Leucine Metabolism Regulates Liver Glucose Production
- (2011) Y. Su et al. DIABETES
- Effects of leucine supplementation and resistance exercise on dexamethasone-induced muscle atrophy and insulin resistance in rats
- (2011) Humberto Nicastro et al. NUTRITION
- Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism
- (2011) Yazmin Macotela et al. PLoS One
- Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs
- (2010) Fiona A. Wilson et al. AMINO ACIDS
- Supplementing l-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs
- (2010) Yulong Yin et al. AMINO ACIDS
- Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
- (2010) Richard C. Scarpulla BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice
- (2010) Giuseppe D'Antona et al. Cell Metabolism
- Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men
- (2010) E. S. Tai et al. DIABETOLOGIA
- Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints
- (2010) Vernon G. Coffey et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets
- (2010) Anne Noatsch et al. EUROPEAN JOURNAL OF NUTRITION
- Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance
- (2010) Pengxiang She et al. JOURNAL OF APPLIED PHYSIOLOGY
- Isoleucine Prevents the Accumulation of Tissue Triglycerides and Upregulates the Expression of PPARα and Uncoupling Protein in Diet-Induced Obese Mice
- (2010) Junko Nishimura et al. JOURNAL OF NUTRITION
- Leucine Supplementation of a Low-Protein Meal Increases Skeletal Muscle and Visceral Tissue Protein Synthesis in Neonatal Pigs by Stimulating mTOR-Dependent Translation Initiation
- (2010) Roberto Murgas Torrazza et al. JOURNAL OF NUTRITION
- Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Anabolism in Young Men and Women
- (2010) Erin L. Glynn et al. JOURNAL OF NUTRITION
- Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance☆
- (2010) Michèle Balage et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus
- (2010) Kaiying Guo et al. Nutrition & Metabolism
- Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women
- (2010) Oliver Fiehn et al. PLoS One
- Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells
- (2009) Philip J. Atherton et al. AMINO ACIDS
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
- (2009) Christopher B. Newgard et al. Cell Metabolism
- Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women
- (2009) K. M. Huffman et al. DIABETES CARE
- Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle
- (2009) Nobumasa Iwanaka et al. JOURNAL OF APPLIED PHYSIOLOGY
- SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD
- (2009) Ramon Amat et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stimulation of Muscle Protein Synthesis by Prolonged Parenteral Infusion of Leucine Is Dependent on Amino Acid Availability in Neonatal Pigs
- (2009) Fiona A. Wilson et al. JOURNAL OF NUTRITION
- Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway
- (2009) Eliane Filiputti et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes
- (2009) Xiaocun Sun et al. Nutrition & Metabolism
- Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
- (2009) D. D. Sears et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation
- (2008) Agus Suryawan et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Acute and Chronic Treatment of L-Isoleucine Ameliorates Glucose Metabolism in Glucose-Intolerant and Diabetic Mice
- (2008) Osamu Ikehara et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
- (2008) J LOPICCOLO et al. DRUG RESISTANCE UPDATES
- Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells
- (2008) Teresa Coll et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
- (2007) Hans C. Dreyer et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More