Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity

The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond

(2021) Rami Mosaoa et al.   Biomolecules

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

(2021) Deyang Yu et al.   Cell Metabolism

Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association

(2021) Tiffany M. Powell-Wiley et al.   CIRCULATION

Predictive value of metabolomic biomarkers for cardiovascular disease risk: a systematic review and meta-analysis

(2020) Peter McGranaghan et al.   BIOMARKERS

Phenylalanine is a novel marker for radiographic knee osteoarthritis progression: the MOST study

(2020) Guangju Zhai et al.   JOURNAL OF RHEUMATOLOGY

Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis

(2020) Jin-Wen Song et al.   Cell Metabolism

Metabolite Profiling Reveals Predictive Biomarkers and the Absence of β-Methyl Amino-l-alanine in Plasma from Individuals Diagnosed with Amyotrophic Lateral Sclerosis

(2020) Michael S. Bereman et al.   JOURNAL OF PROTEOME RESEARCH

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

(2020) Leiluo Geng et al.   Nature Reviews Endocrinology

The Bovine Metabolome

(2020) Aidin Foroutan et al.   Metabolites

Metabolomic analysis coupled with extreme phenotype sampling identified that lysophosphatidylcholines are associated with multisite musculoskeletal pain

(2020) Ming Liu et al.   PAIN

Sphingomyelin is involved in multisite musculoskeletal pain

(2020) Feng Pan et al.   PAIN

A Novel Dietary Intervention Reduces Circulatory Branched-Chain Amino Acids by 50%: A Pilot Study of Relevance for Obesity and Diabetes

(2020) Imran Ramzan et al.   Nutrients

Complication-specific direct medical costs by body mass index for 13 obesity-related complications: a retrospective database study

(2020) Victoria Divino et al.   Journal of Managed Care & Specialty Pharmacy

Unfavorable Associations Between Serum Trimethylamine N-Oxide and L-Carnitine Levels With Components of Metabolic Syndrome in the Newfoundland Population

(2019) Xiang Gao et al.   Frontiers in Endocrinology

The pivotal role of protein acetylation in linking glucose and fatty acid metabolism to β-cell function

(2019) Yuqing Zhang et al.   Cell Death & Disease

Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults

(2019) Minoo Bagheri et al.   Lipids in Health and Disease

Obesity, kidney dysfunction and hypertension: mechanistic links

(2019) John E. Hall et al.   Nature Reviews Nephrology

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

(2019) Meiyi Zhou et al.   DIABETES

Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population

(2019) Xiang Gao et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Activation of The Phosphatidylcholine to Lysophosphatidylcholine Pathway Is Associated with Osteoarthritis Knee Cartilage Volume Loss Over Time

(2019) Guangju Zhai et al.   Scientific Reports

Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial

(2019) Yanislava Karusheva et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Metabolomics Signature for Non‐Responders to Total Joint Replacement Surgery in Primary Osteoarthritis Patients: The Newfoundland Osteoarthritis Study

(2019) Christie A. Costello et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats

(2019) Robert W. McGarrah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

(2018) Milan Holeček   Nutrition & Metabolism

Neuropathic pain in end-stage hip and knee osteoarthritis: differential associations with patient-reported pain at rest and pain on activity

(2018) J.D. Power et al.   OSTEOARTHRITIS AND CARTILAGE

SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice

(2018) Yipeng Du et al.   EBioMedicine

Restoration of metabolic health by decreased consumption of branched-chain amino acids

(2017) Nicole E. Cummings et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Socioeconomic Burden of Obesity

(2017) Jakob Kjellberg et al.   Obesity Facts

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

(2016) R. S. Kelly et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults

(2016) Sebastian Rauschert et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance

(2016) Chisa Takashina et al.   Nutrition & Metabolism

Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals

(2016) Xiang Gao et al.   Nutrition & Metabolism

Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study

(2016) Johanna H.M. Stroeve et al.   Obesity

Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis

(2016) Weidong Zhang et al.   RHEUMATOLOGY

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

(2015) Marie Favennec et al.   Obesity

Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review

(2014) H. Bliddal et al.   Obesity Reviews

The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis

(2013) Gitanjali M. Singh et al.   PLoS One

The Multicenter Osteoarthritis Study: Opportunities for Rehabilitation Research

(2013) Neil A. Segal et al.   PM&R

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis

(2010) G. Zhai et al.   ANNALS OF THE RHEUMATIC DISEASES

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

(2008) J-P Raynauld et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased C3-Carnitine in a Healthy Premature Infant

(2008) K. A Chapman et al.   CLINICAL CHEMISTRY