Leucine-induced anabolic-catabolism: two sides of the same coin

Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice

(2015) José M. Costa Júnior et al.   AMINO ACIDS

Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis

(2015) Cynthia Tsien et al.   HEPATOLOGY

Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice

(2015) Lizhi Fu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leucine Supplementation Improves Acquired Growth Hormone Resistance in Rats with Protein-Energy Malnutrition

(2015) Xuejin Gao et al.   PLoS One

Leucine minimizes denervation-induced skeletal muscle atrophy of rats through akt/mtor signaling pathways

(2015) Carolina B. Ribeiro et al.   Frontiers in Physiology

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

(2015) Kimberly A. Coughlan et al.   PLoS One

Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini-review

(2014) Nicholas P. Gannon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells

(2014) José L. Areta et al.   NUTRITION RESEARCH

Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirtuin-Mediated Metabolism in Muscle Cells and Adipocytes

(2014) Antje Bruckbauer et al.   PLoS One

Leucine Supplementation Improves Skeletal Muscle Regeneration after Cryolesion in Rats

(2014) Marcelo G. Pereira et al.   PLoS One

Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells

(2013) Roger A. Vaughan et al.   AMINO ACIDS

Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females

(2013) Marcus Moberg et al.   Applied Physiology Nutrition and Metabolism

Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats

(2013) Fumiaki YOSHIZAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A dipeptide and an amino acid present in whey protein hydrolysate increase translocation of GLUT-4 to the plasma membrane in Wistar rats

(2013) P.N. Morato et al.   FOOD CHEMISTRY

Dietary stimulators of the PGC-1 superfamily and mitochondrial biosynthesis in skeletal muscle. A mini-review

(2013) Roger A. Vaughan et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Acute uremia suppresses leucine-induced signal transduction in skeletal muscle

(2013) Kevin L. McIntire et al.   KIDNEY INTERNATIONAL

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

(2013) Julia Brenmoehl et al.   MITOCHONDRION

Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues

(2013) Xiang Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

1,25(OH)2-vitamin D3enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes

(2013) Jérôme Salles et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels

(2013) Elke Binder et al.   PLoS One

Leucine and mTORC1: a complex relationship

(2012) Kayleigh M. Dodd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

(2012) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein

(2012) Shanon L. Casperson et al.   CLINICAL NUTRITION

Upregulation of amino acid transporter expression induced by l-leucine availability in L6 myotubes is associated with ATF4 signaling through mTORC1-dependent mechanism

(2012) Jun-qiu Luo et al.   NUTRITION

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

(2012) Antje Bruckbauer et al.   Nutrition & Metabolism

Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways

(2012) Agus Suryawan et al.   PEDIATRIC RESEARCH

Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis

(2011) S. M. Pasiakos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

An amino acid mixture improves glucose tolerance and insulin signaling in Sprague-Dawley rats

(2011) Jeffrey R. Bernard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine-stimulated mTOR signaling is partly attenuated in skeletal muscle of chronically uremic rats

(2011) Yu Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of leucine supplementation and resistance exercise on dexamethasone-induced muscle atrophy and insulin resistance in rats

(2011) Humberto Nicastro et al.   NUTRITION

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine

(2010) Charles H. Lang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs

(2010) Fiona A. Wilson et al.   AMINO ACIDS

Supplementing l-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs

(2010) Yulong Yin et al.   AMINO ACIDS

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle

(2010) A. K. Saha et al.   DIABETES

Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints

(2010) Vernon G. Coffey et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets

(2010) Anne Noatsch et al.   EUROPEAN JOURNAL OF NUTRITION

Leucine Supplementation of a Low-Protein Meal Increases Skeletal Muscle and Visceral Tissue Protein Synthesis in Neonatal Pigs by Stimulating mTOR-Dependent Translation Initiation

(2010) Roberto Murgas Torrazza et al.   JOURNAL OF NUTRITION

Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Anabolism in Young Men and Women

(2010) Erin L. Glynn et al.   JOURNAL OF NUTRITION

Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance☆

(2010) Michèle Balage et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Leucine promotes leptin receptor expression in mouse C2C12 myotubes through the mTOR pathway

(2010) Xiangbing Mao et al.   MOLECULAR BIOLOGY REPORTS

Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

(2010) Kaiying Guo et al.   Nutrition & Metabolism

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue

(2009) Y. Cheng et al.   DIABETES

The crystal structures of two cuticle-degrading proteases from nematophagous fungi and their contribution to infection against nematodes

(2009) Lianming Liang et al.   FASEB JOURNAL

Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle

(2009) Nobumasa Iwanaka et al.   JOURNAL OF APPLIED PHYSIOLOGY

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulation of Muscle Protein Synthesis by Prolonged Parenteral Infusion of Leucine Is Dependent on Amino Acid Availability in Neonatal Pigs

(2009) Fiona A. Wilson et al.   JOURNAL OF NUTRITION

Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway

(2009) Eliane Filiputti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes

(2009) Xiaocun Sun et al.   Nutrition & Metabolism

Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation

(2008) Agus Suryawan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of peroxisome proliferator-activated receptor α (PPARα) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells

(2008) Naoya Nakai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle

(2007) Hans C. Dreyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM