Recent insights into autophagy and metals/nanoparticles exposure

Advances on the Influence of Methylmercury Exposure during Neurodevelopment

(2022) Jingjing Pan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanism of chromium-induced toxicity in lungs, liver, and kidney and their ameliorative agents

(2022) Rituraj Chakraborty et al.   BIOMEDICINE & PHARMACOTHERAPY

Melatonin improves arsenic-induced hypertension through the inactivation of the Sirt1/autophagy pathway in rat

(2022) Soudabeh Balarastaghi et al.   BIOMEDICINE & PHARMACOTHERAPY

ROS antagonizes the protection of Parkin-mediated mitophagy against aluminum-induced liver inflammatory injury in mice

(2022) Bonan Xiao et al.   FOOD AND CHEMICAL TOXICOLOGY

Cellular Conditions Responsible for Methylmercury-Mediated Neurotoxicity

(2022) Masatake Fujimura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PINK1/Parkin-mediated mitophagy is activated to protect against testicular damage caused by aluminum

(2022) Menglin Liu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Lead Exposure Induced Neural Stem Cells Death via Notch Signaling Pathway and Gut-Brain Axis

(2022) Lijuan Sun et al.   Oxidative Medicine and Cellular Longevity

d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway

(2021) Zhiming Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of berberine nanoemulsion Photodynamic therapy on cervical carcinoma cell line

(2021) Barbara Freitas Floriano et al.   Photodiagnosis and Photodynamic Therapy

Inflammatory Injury and Mitophagy in the Cock Heart Induced by the Oral Administration of Hexavalent Chromium

(2021) Yue Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Comparative Study of Cytotoxicity, DNA Damage and Oxidative Stress Induced by Heavy Metals Cd(II), Hg(II) and Cr(III) in Yeast

(2021) Jingwen Wang et al.   CURRENT MICROBIOLOGY

Rosmarinus officinalis essential oil modulates renal toxicity and oxidative stress induced by potassium dichromate in rats

(2021) Fatma M. El-Demerdash et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The role of autophagy in metal-induced urogenital carcinogenesis

(2021) Uttara Saran et al.   SEMINARS IN CANCER BIOLOGY

Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis

(2021) Yan-Hong Cui et al.   Nature Communications

Health Risk Assessment of Occupational Exposure to Hexavalent Chromium in Iranian Workplaces: a Meta-analysis Study

(2021) Nafiseh Nasirzadeh et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Arsenic and antimony co-induced nephrotoxicity via autophagy and pyroptosis through ROS-mediated pathway in vivo and in vitro

(2021) Fang Wan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Evaluation of toxic effects induced by arsenic trioxide or/and antimony on autophagy and apoptosis in testis of adult mice

(2021) Shaofeng Wu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Arsenic or/and antimony induced mitophagy and apoptosis associated with metabolic abnormalities and oxidative stress in the liver of mice

(2021) Gaolong Zhong et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases

(2021) Suryakant Niture et al.   Journal of Toxicology

Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer’s Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota

(2021) Changjiang Li et al.   ACS Applied Materials & Interfaces

Attenuation of Hg(II)-induced cellular and DNA damage in human blood cells by uric acid

(2021) Shahbaz Ahmad et al.   Biochemistry and Cell Biology

ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice

(2021) Yilong Cui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen

(2021) Guifang Zhao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Evidence of melatonin ameliorative effects on the blood-testis barrier and sperm quality alterations induced by cadmium in the rat testis

(2021) Massimo Venditti et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

MiR-155 promotes cadmium-induced autophagy in rat hepatocytes by suppressing Rheb expression

(2021) Hui Zou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Attenuation of Pb-induced Aβ generation and autophagic dysfunction via activation of SIRT1: Neuroprotective properties of resveratrol

(2021) Lin Bai et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

SIRT1 / mTOR pathway‐mediated autophagy dysregulation promotes Pb‐induced hepatic lipid accumulation in HepG2 cells

(2021) Yanan Zhao et al.   ENVIRONMENTAL TOXICOLOGY

Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells

(2021) Caijun Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Luteolin alleviates inorganic mercury-induced kidney injury via activation of the AMPK/mTOR autophagy pathway

(2021) Xinyue Xu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Effects of Cadmium and/or Lead on Autophagy and Liver Injury in Rats

(2020) Hui Zou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Titanium dioxide nanoparticles promote oxidative stress, autophagy and reduce NLRP3 in primary rat astrocytes

(2020) José Antonio Pérez-Arizti et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway

(2020) Huan Li et al.   NEUROTOXICITY RESEARCH

The Role of Ubiquitin-Proteasome Pathway and Autophagy-Lysosome Pathway in Cerebral Ischemia

(2020) Chunli Chen et al.   Oxidative Medicine and Cellular Longevity

Effects of lead and cadmium on the immune system and cancer progression

(2020) Maryam Ebrahimi et al.   Journal of Environmental Health Science and Engineering

Mitophagy is involved in chromium (VI)-induced mitochondria damage in DF-1 cells

(2020) Yuliang Xu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

TiO2 nanoparticles enhance the chemotherapeutic effects of 5-fluorouracil in human AGS gastric cancer cells via autophagy blockade

(2020) Shiva Azimee et al.   LIFE SCIENCES

Magnesium Increases the Protective Effect of Citicoline on Aluminum Chloride-induced Cognitive Impairment

(2020) Ali Hosseini-Sharifabad et al.   Clinical Psychopharmacology and Neuroscience

Metals and Molecular Carcinogenesis

(2020) Yusha Zhu et al.   CARCINOGENESIS

PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling

(2020) Tianxiao Duan et al.   TOXICOLOGY IN VITRO

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

(2020) Shokouh Attarilar et al.   Frontiers in Bioengineering and Biotechnology

Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity

(2020) Yujing Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Involvement of Mitophagy in Aluminum Oxide Nanoparticle–Induced Impairment of Learning and Memory in Mice

(2020) Tao Huang et al.   NEUROTOXICITY RESEARCH

Endoplasmic reticulum stress and autophagy contributed to cadmium nephrotoxicity in HK-2 cells and Sprague-Dawley rats

(2020) Jian-Ri Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway

(2020) Jie Xu et al.   Chinese Medicine

Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease

(2020) Niklas Reich et al.   Frontiers in Neuroscience

Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation

(2020) Chao Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Autophagy in Sertoli cell protects against environmental cadmium-induced germ cell apoptosis in mouse testes

(2020) Guo-Xiang Zhou et al.   ENVIRONMENTAL POLLUTION

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field

(2019) Meghri Katerji et al.   Oxidative Medicine and Cellular Longevity

Silver nanoparticles induce protective autophagy via Ca2+/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells and rat brains

(2019) Lin Li et al.   Nanotoxicology

Exposure routes and health effects of heavy metals on children

(2019) Muwaffak Al osman et al.   BIOMETALS

Antioxidant, antiapoptotic, antigenotoxic, and hepatic ameliorative effects of L-carnitine and selenium on cadmium-induced hepatotoxicity and alterations in liver cell structure in male mice

(2019) Helal S.H. Abu-El-Zahab et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway

(2019) Hongyan Yu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Pathways of arsenic uptake and efflux

(2019) Luis D. Garbinski et al.   ENVIRONMENT INTERNATIONAL

Dysregulated autophagy and lysosome function are linked to exosome production via miR‐155 in alcoholic liver disease

(2019) Mrigya Babuta et al.   HEPATOLOGY

Inhibition of Autophagy Alleviates Cadmium-Induced Mouse Spleen and Human B Cells Apoptosis

(2019) Jie Gu et al.   TOXICOLOGICAL SCIENCES

MeHg-induced autophagy via JNK/Vps34 complex pathway promotes autophagosome accumulation and neuronal cell death

(2019) Tianji Lin et al.   Cell Death & Disease

Cadmium toxicity: effects on human reproduction and fertility

(2019) Sunil Kumar et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Understanding Nanoparticle Toxicity Mechanisms To Inform Redesign Strategies To Reduce Environmental Impact

(2019) Joseph T. Buchman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Protective Effect of Purple Tomato Anthocyanidin on Chromium(VI)-Induced Autophagy in LMH Cells by Inhibiting Endoplasmic Reticulum Stress

(2019) Kangping Liu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway

(2019) Fei Yin et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview

(2019) Zeeshanur Rahman et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis

(2019) Ye Tao et al.   CHEMOSPHERE

The influence of titanium dioxide nanoparticles on their cellular response to macrophage cells

(2019) Qinglian Hu et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Selenium protection against mercury neurotoxicity: Modulation of apoptosis and autophagy in the anterior pituitary

(2019) Hoda Mahmoud El Asar et al.   LIFE SCIENCES

Exposure to Inorganic Arsenic and Lead and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis

(2019) Meng Wang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Redox interactions and genotoxicity of metal-based nanoparticles: A comprehensive review

(2019) Keywan Mortezaee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Molecular mechanisms underlying titanium dioxide nanoparticles (TiO2NP) induced autophagy in mesenchymal stem cells (MSC)

(2019) Shunbang Yu et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Calcimimetic compound NPS R-467 protects against chronic cadmium-induced mouse kidney injury by restoring autophagy process

(2019) Jie Gu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes

(2019) Hui Zou et al.   TOXICOLOGY LETTERS

Autophagy Protects MC3T3-E1 Cells upon Aluminum-Induced Apoptosis

(2018) Xu Yang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Ascorbic acid ameliorates lead-induced apoptosis in the cerebellar cortex of developing rats

(2018) Sung Min Nam et al.   BRAIN RESEARCH

Aluminum: A potentially toxic metal with dose-dependent effects on cardiac bioaccumulation, mineral distribution, DNA oxidation and microstructural remodeling

(2018) Rômulo D. Novaes et al.   ENVIRONMENTAL POLLUTION

Interplay between elemental imbalance-related PI3K/Akt/mTOR-regulated apoptosis and autophagy in arsenic (III)-induced jejunum toxicity of chicken

(2018) Yu Wang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Bone impairment caused by AlCl 3 is associated with activation of the JNK apoptotic pathway mediated by oxidative stress

(2018) Xu Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Aluminum's preferential binding site in proteins: sidechain of amino acids versus backbone interactions

(2018) Jon I. Mujika et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

CysLTR1 Blockage Ameliorates Liver Injury Caused by Aluminum-Overload via PI3K/AKT/mTOR-Mediated Autophagy Activation in Vivo and in Vitro

(2018) Congli Hu et al.   MOLECULAR PHARMACEUTICS

Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway

(2018) Xueyan Gu et al.   TOXICOLOGY LETTERS

Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K/Akt/mTOR signaling pathway: involvement of blood–brain barrier’s tight junction proteins

(2018) Ram Kumar Manthari et al.   ARCHIVES OF TOXICOLOGY

Titanium dioxide nanoparticles induce proteostasis disruption and autophagy in human trophoblast cells

(2018) Yuqing Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Arsenic-Induced Autophagy in the Developing Mouse Cerebellum: Involvement of the Blood–Brain Barrier’s Tight-Junction Proteins and the PI3K–Akt–mTOR Signaling Pathway

(2018) Ram Kumar Manthari et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cadmium-induced neurotoxicity: still much ado

(2018) Alessandra Pacini et al.   Neural Regeneration Research

Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation

(2018) Takamitsu Unoki et al.   Frontiers in Genetics

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells

(2018) Huifeng Pi et al.   Autophagy

Cr (VI) induces crosstalk between apoptosis and autophagy through endoplasmic reticulum stress in A549 cells

(2018) Hong Ge et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oxidative stress in the neurodegenerative brain following lifetime exposure to lead in rats: Changes in lifespan profiles

(2018) Chang Feng et al.   TOXICOLOGY

Zinc oxide nanoparticles impacts: cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity

(2018) Sanjiv Singh   TOXICOLOGY MECHANISMS AND METHODS

Pb disrupts autophagic flux through inhibiting the formation and activity of lysosomes in neural cells

(2018) Xiaozhen Gu et al.   TOXICOLOGY IN VITRO

A Ca2+ chelator ameliorates chromium (VI)-induced hepatocyte L-02 injury via down-regulation of voltage-Dependent anion channel 1 (VDAC1) expression

(2017) Xing Yi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Mitochondrial Biogenesis in Response to Chromium (VI) Toxicity in Human Liver Cells

(2017) Xiali Zhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trivalent chromium induces autophagy by activating sphingomyelin phosphodiesterase 2 and increasing cellular ceramide levels in renal HK2 cells

(2017) Cheng-Lin Yang et al.   MOLECULAR CARCINOGENESIS

Neuroprotective Efficacy of Mitochondrial Antioxidant MitoQ in Suppressing Peroxynitrite-Mediated Mitochondrial Dysfunction Inflicted by Lead Toxicity in the Rat Brain

(2017) Arpan Kumar Maiti et al.   NEUROTOXICITY RESEARCH

Effects of exposure to nano and bulk sized TiO 2 and CuO in Lemna minor

(2017) Jasna Dolenc Koce   PLANT PHYSIOLOGY AND BIOCHEMISTRY

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

(2017) Xiang-Bin Song et al.   Cell Death & Disease

Metabolism, toxicity and anticancer activities of arsenic compounds

(2017) Islam Khairul et al.   Oncotarget

Rat white adipocytes activate p85/p110 PI3K and induce PM GLUT4 in response to adrenoceptor agonists or aluminum fluoride

(2016) Y Ohsaka et al.   ACTA PHYSIOLOGICA HUNGARICA

Endoplasmic Reticulum Stress and Apoptosis Triggered by Sub-Chronic Lead Exposure in Mice Spleen: a Histopathological Study

(2016) Giovanni Corsetti et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Metal Ion Imbalance-Related Oxidative Stress Is Involved in the Mechanisms of Liver Injury in a Rat Model of Chronic Aluminum Exposure

(2016) Yang Yang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The Toxicity of Aluminum Chloride on Kidney of Rats

(2016) Jianyu Liu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Structure and function of the ULK1 complex in autophagy

(2016) Mary G Lin et al.   CURRENT OPINION IN CELL BIOLOGY

A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment

(2016) Xiangyang Wu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Restoration of autophagy by puerarin in lead-exposed primary rat proximal tubular cells via regulating AMPK-mTOR signaling

(2016) Xiangbin Song et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The role of STIM1 in the Cr(vi)-induced [Ca2+]iincrease and cell injury in L-02 hepatocytes

(2016) Xing Yi et al.   Metallomics

Iron Oxide Nanoparticles Induce Autophagosome Accumulation through Multiple Mechanisms: Lysosome Impairment, Mitochondrial Damage, and ER Stress

(2016) Xudong Zhang et al.   MOLECULAR PHARMACEUTICS

Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity

(2016) Ziyan Zhang et al.   NEUROCHEMICAL RESEARCH

From the Cover: Autophagy Induction Contributes to Cadmium Toxicity in Mesenchymal Stem Cells via AMPK/FOXO3a/BECN1 Signaling

(2016) Min Yang et al.   TOXICOLOGICAL SCIENCES

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

(2016) Anurag R. Mishra et al.   TOXICOLOGICAL SCIENCES

5-lipoxygenase activation is involved in the mechanisms of chronic hepatic injury in a rat model of chronic aluminum overload exposure

(2016) Shaoshan Mai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

(2016) Haiyan Chen et al.   TOXICOLOGY LETTERS

Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells

(2016) Lu Chen et al.   Scientific Reports

Autophagy and p53

(2016) Eileen White   Cold Spring Harbor Perspectives in Medicine

The Protective Effect of Gangliosides on Lead (Pb)-Induced Neurotoxicity Is Mediated by Autophagic Pathways

(2016) Hongtao Meng et al.   International Journal of Environmental Research and Public Health

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

(2015) Qiuyue Zhang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Lead toxicity induces autophagy to protect against cell death through mTORC1 pathway in cardiofibroblasts

(2015) Li Sui et al.   BIOSCIENCE REPORTS

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

(2015) David G. McEwan et al.   MOLECULAR CELL

Cadmium-induced autophagy promotes survival of rat cerebral cortical neurons by activating class III phosphoinositide 3-kinase/beclin-1/B-cell lymphoma 2 signaling pathways

(2015) QI-WEN WANG et al.   Molecular Medicine Reports

Lead Exposure Impairs Hippocampus Related Learning and Memory by Altering Synaptic Plasticity and Morphology During Juvenile Period

(2015) Tao Wang et al.   MOLECULAR NEUROBIOLOGY

Assessment of the lung toxicity of copper oxide nanoparticles: current status

(2015) Maqusood Ahamed et al.   Nanomedicine

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain

(2015) Xue Wei et al.   NEUROTOXICOLOGY

Temporal Changes in Rat Liver Gene Expression after Acute Cadmium and Chromium Exposure

(2015) Michael S. Madejczyk et al.   PLoS One

Toxicity of titanium dioxide nanoparticles in central nervous system

(2015) Magdalena Czajka et al.   TOXICOLOGY IN VITRO

Mercury-induced dysfunctions in multiple organelles leading to cell death

(2015) C.S. Vergilio et al.   TOXICOLOGY IN VITRO

Cadmium chloride inhibits lactate gluconeogenesis in mouse renal proximal tubules: An in vitro metabolomic approach with 13C NMR

(2015) Hassan Faiz et al.   TOXICOLOGY LETTERS

Autophagy plays a protective role in cell death of osteoblasts exposure to lead chloride

(2015) Xiao-hua Lv et al.   TOXICOLOGY LETTERS

Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells

(2015) Kyeong-Nam Yu et al.   PLoS One

Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB

(2015) Bao-Fei Sun et al.   PLoS One

Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes

(2014) Fang Yuntao et al.   ARCHIVES OF TOXICOLOGY

Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death

(2014) Xuezhong Gong et al.   ARCHIVES OF TOXICOLOGY

Activation of Autophagy Protects Against ROS-Mediated Mitochondria-Dependent Apoptosis in L-02 Hepatocytes Induced by Cr(VI)

(2014) Ying Xie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Toxic Metals and Autophagy

(2014) Sarmishtha Chatterjee et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Interplay of calcium and cadmium in mediating cadmium toxicity

(2014) Grace Choong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

(2014) Calvin C. Willhite et al.   CRITICAL REVIEWS IN TOXICOLOGY

Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring

(2014) Abbas Mohammadipour et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Sodium arsenite induces ROS-dependent autophagic cell death in pancreatic β-cells

(2014) Xue-Xin Zhu et al.   FOOD AND CHEMICAL TOXICOLOGY

Biochemical and histopathological effects of subchronic oral exposure of rats to a mixture of five toxic elements

(2014) Haiyan Zhu et al.   FOOD AND CHEMICAL TOXICOLOGY

Acute exposure to ZnO nanoparticles induces autophagic immune cell death

(2014) Brandon M. Johnson et al.   Nanotoxicology

Ameliorative Effects of Ferulic Acid Against Lead Acetate-Induced Oxidative Stress, Mitochondrial Dysfunctions and Toxicity in Prepubertal Rat Brain

(2014) Venkareddy Lalith Kumar et al.   NEUROCHEMICAL RESEARCH

Changes in rat urinary porphyrin profiles predict the magnitude of the neurotoxic effects induced by a mixture of lead, arsenic and manganese

(2014) Vanda Andrade et al.   NEUROTOXICOLOGY

Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition

(2014) Ruchi Roy et al.   TOXICOLOGY LETTERS

Hexavalent Chromium-Induced Apoptosis in Rat Uterus: Involvement of Oxidative Stress

(2013) Neila Marouani et al.   Archives of Environmental & Occupational Health

Induction of cytoprotective autophagy in PC-12 cells by cadmium

(2013) Qiwen Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells

(2013) Seung-Hee Chang et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

(2013) Chen-Chen Tan et al.   NEUROBIOLOGY OF AGING

Disturbance of Intracellular Calcium Homeostasis and CaMKII/CREB Signaling is Associated with Learning and Memory Impairments Induced by Chronic Aluminum Exposure

(2013) Biao Wang et al.   NEUROTOXICITY RESEARCH

Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration

(2013) Tzu-Ying Lee et al.   Particle and Fibre Toxicology

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Human exposure to aluminium

(2013) Christopher Exley   Environmental Science-Processes & Impacts

Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring

(2012) Jawahar B. Samuel et al.   ENVIRONMENTAL TOXICOLOGY

Cr(VI) induces the decrease of ATP level and the increase of apoptosis rate mediated by ROS or VDAC1 in L-02 hepatocytes

(2012) Yang Yuan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury

(2012) Jianbin Zhang et al.   International Journal of Biological Sciences

Autophagy is involved in nanoalumina-induced cerebrovascular toxicity

(2012) Lei Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells

(2012) Tingting Sun et al.   PLoS One

Effects of hexavalent chromium on reproductive functions of male adult rats

(2012) Neila Marouani et al.   Reproductive Biology

Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles

(2012) Yun Wang et al.   Small

Autophagy Is a Cell Self-Protective Mechanism Against Arsenic-Induced Cell Transformation

(2012) Tao Zhang et al.   TOXICOLOGICAL SCIENCES

Low concentration of mercury induces autophagic cell death in rat hepatocytes

(2012) Sarmishtha Chatterjee et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment

(2011) Xiaowei Ma et al.   ACS Nano

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells

(2011) Blanka Halamoda Kenzaoui et al.   BIOCHEMICAL JOURNAL

Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles

(2011) Mohd Imran Khan et al.   BIOMATERIALS

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Arsenic-induced oxidative stress and its reversibility

(2011) Swaran J.S. Flora   FREE RADICAL BIOLOGY AND MEDICINE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Biomarker discovery and proteomic evaluation of cadmium toxicity on a collembolan species, Paronychiurus kimi (Lee)

(2011) Jino Son et al.   PROTEOMICS

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells

(2011) Young-Ok Son et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Aluminum maltolate induces primary rat astrocyte apoptosis via overactivation of the class III PI3K/Beclin 1-dependent autophagy signal

(2011) Ke-Wu Zeng et al.   TOXICOLOGY IN VITRO

Tubulointerstitial damage as the major pathological lesion in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka

(2011) Shanika Nanayakkara et al.   Environmental Health and Preventive Medicine

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

DNA Damage and Decrease of Cellular Oxidase Activity in Piglet Sertoli Cells Exposed to Arsanilic Acid

(2010) Ming ZHANG et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Chromium-induced biochemical, genotoxic and histopathologic effects in liver and kidney of goldfish, carassius auratus

(2010) Venkatramreddy Velma et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

The Absence of Interleukin-6 Enhanced Arsenite-Induced Renal Injury by Promoting Autophagy of Tubular Epithelial Cells with Aberrant Extracellular Signal-Regulated Kinase Activation

(2009) Akihiko Kimura et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of Lead and/or Cadmium on the Oxidative Damage of Rat Kidney Cortex Mitochondria

(2009) Lin Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Reproductive, Developmental, and Neurobehavioral Effects of Methylmercury in Fishes

(2009) JUDITH S. WEIS   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Cadmium Toxicity toward Autophagy through ROS-Activated GSK-3β in Mesangial Cells

(2009) Sheng-Hao Wang et al.   TOXICOLOGICAL SCIENCES

Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway

(2008) S. H. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Muscarinic cholinergic modulation of synaptic transmission and plasticity in rat hippocampus following chronic lead exposure

(2008) Mingliang Tang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups

(2008) Qiansheng Hu et al.   NEUROTOXICOLOGY