Article
Toxicology
Chunjie Huang, Di Wu, Faheem Ahmed Khan, Yongsheng Wang, Junjie Xu, Chunhai Luo, Kejia Zhang, Fei Sun, Lijun Huo
Summary: This study reported the hazardous effects of zinc oxide nanoparticles (ZnO NP) on the development of mouse oocytes and pre-implantation embryos. ZnO NP compromised the meiosis process, caused cellular stress, activated autophagy and apoptosis, disrupted cytoskeleton architecture, and induced DNA damage, leading to developmental arrest and degeneration of oocytes and early embryos. The study suggests that ZnO NP is toxic to oocytes and embryos in mammals, highlighting the need for careful evaluation of human exposure and its impact on reproductive health.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Qing Li, Yi Wang, Shu-Jie Yang, Yu Liu, Xiang Ma, Lu Liu, Si-Hong Li, Dong Niu, Xing Duan
Summary: Maternal diabetes has negative effects on oocyte quality, but melatonin supplementation can protect oocytes from these damages and improve oocyte quality in assisted reproductive technologies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mahmoud Abdelghaffar Emam, Sameh Mohamed Farouk, Ahmed Aljazzar, Abeer A. A. Abdelhameed, Abeer A. A. Eldeeb, Fatma Abdel-monem Gad
Summary: Curcumin and cinnamon have shown protective effects against lead acetate-induced splenotoxicity in rats, by restoring hemato-biochemical, immunological, oxidative stress, histological, and immunohistological parameters.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Feixue Liu, Xueqing Li, Babatunde Kazeem Bello, Tianmeng Zhang, Haitao Yang, Kun Wang, Jingquan Dong
Summary: With the increasing use of pesticides, there is a growing concern about the levels of residual pesticides in the aquatic environment and their impact on non-target organisms. This study focused on the acute toxic effects of difenoconazole (DFZ), a class of long-lasting fungicides, on the spleen tissue of carp. The results showed that DFZ caused severe histopathology, apoptosis, oxidative stress, and inflammation in the spleen tissue of carp, leading to tissue damage. These findings highlight the importance of ensuring the safety of aquatic organisms in pesticide usage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Medicinal
Li-juan Gao, Ping Li, Tengyun Ma, Zhan-qiong Zhong, Shi-jun Xu
Summary: This study demonstrated that Ligustilide has neuroprotective effects on Alzheimer's disease cell models through regulating endoplasmic reticulum stress (ERS) and autophagy. Ligustilide decreased apoptosis rate, improved cell viability, and effectively modulated ERS by inhibiting the over-activation of the GRP78/PERK/CHOP signaling pathway. Additionally, Ligustilide alleviated the accumulation of autophagy vacuoles, reduced the ratio of LC3B-II/I, and up-regulated lysosomal acidity and Cathepsin D expression.
PHYTOTHERAPY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Qun Lu, Chao Huang, Zhiming Cui
Summary: Sinomenine, a natural compound from Sinomenium acutum, has shown beneficial effects in various CNS disorders, including cerebral ischemia, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Its mechanisms of action involve inhibition of oxidative stress, neuroinflammation, and neuronal apoptosis. Sinomenine also exhibits anti-glioma effects and improves morphine dependence and sleep disturbance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Ylenia Marino, Rosalia Crupi, Enrico Gugliandolo, Francesco Macri, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study evaluated the modulation of autophagy, oxidative stress, and apoptosis with Acai Berries in a rat model of endometriosis. The results showed that Acai Berry inhibited the phosphorylation of PI3K, AKT, and ERK1/2, promoting autophagy, and exerted regulatory effects on cell apoptosis and oxidative stress.
Article
Environmental Sciences
Shanshan Zhu, Yingwei Liu, Yangwei Li, Jiangnan Yi, Bijing Yang, Yuanliang Li, Zhuanxu Ouyang, Bingxian Liu, Peng Shang, Khalid Mehmood, Rao Zahid Abbas, Shakeel Ahmed, Yung-Fu Chang, Jianying Guo, Jiaqiang Pan, Lianmei Hu, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: Exposure to Butachlor can cause cancer, lymphocyte aberration, and immunotoxic effects, leading to toxic effects on the spleen of mice and triggering an immune response by targeting the CYTC/BCL2/M-TOR pathway and caspase cascading activation of spleen autophagy and apoptosis pathways.
Review
Immunology
Jin-yan Dong, Hong-Lin Yin, Hao Hao, Yang Liu
Summary: Autophagy is a highly conserved process that maintains cell stability and function, and helps resist pathogen invasion. It plays a role in various diseases, including lung diseases like acute lung injury (ALI). Traditional Chinese medicine has been used to regulate autophagy and improve ALI symptoms. This paper introduces the molecular mechanism and common pathways of autophagy regulation, as well as the relationship between autophagy and ALI, and summarizes the active ingredients of traditional Chinese medicine that improve ALI symptoms by regulating autophagy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Li'E Hou, Tiantian Gu, Kaiqi Weng, Yu Zhang, Yang Zhang, Guohong Chen, Qi Xu
Summary: This study found that excessive granulosa cell apoptosis and autophagy occur during goose broodiness, which is caused by oxidative stress. Additionally, vitamin E treatment effectively protected granulosa cells from oxidative stress-induced apoptosis and autophagy, alleviating these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Hongrui Guo, Heng Yin, Zhicai Zuo, Zhuangzhi Yang, Yue Yang, Ling Wei, Hengmin Cui, Huidan Deng, Xia Chen, Jian Chen, Yanqiu Zhu, Ping Ouyang, Yi Geng, Zongjun Du, Huaqiao Tang, Fengyuan Wang, Jing Fang
Summary: The study found that nickel-mediated renal injury is associated with oxidative stress-induced apoptosis and autophagy. NAC, as an effective antioxidant, can suppress nickel-induced oxidative stress and alleviate kidney damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Tianmeng Zhang, Zhuhua Dong, Feixue Liu, Enzhuang Pan, Nana He, Fenfen Ma, Xinyu Wu, Yan Wang, Jingquan Dong
Summary: This study established an acute spleen injury model in carp to assess the non-target toxicity of avermectin. The results showed that avermectin damaged spleen tissue structure, induced inflammation and apoptosis, and caused oxidative stress in carp. These findings have important implications for further studies on the effects of avermectin on non-target organisms.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Parul Sharma, Naveen Kaushal, Leena Regi Saleth, Saeid Ghavami, Sanjiv Dhingra, Parminder Kaur
Summary: Spermatogenesis is a complex process that can lead to male infertility due to DNA deterioration caused by oxidative stress. The interplay between apoptosis and autophagy, as well as the involvement of various genes and proteins, plays a crucial role in male germ cell damage. Epigenetic deregulation of apoptosis and autophagy under oxidative stress conditions can further contribute to sperm cell damage. Understanding the crosslink between apoptosis and autophagy in male germ cells under stress conditions is important for developing effective therapeutic strategies for infertility.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Hany H. Arab, Ahmed M. Ashour, Ahmed H. Eid, El-Shaimaa A. Arafa, Hana J. Al Khabbaz, Sarah A. Abd El-Aal
Summary: This study found that galangin can attenuate cadmium-induced nephrotoxicity through reducing oxidative stress and apoptosis, as well as promoting autophagy.
Article
Medicine, Research & Experimental
Jihang Dai, Yaxin Zhang, Deng Chen, Duoyun Chen, Xiaolei Li, Jingcheng Wang, Yu Sun
Summary: This study found that Glabridin can increase the expression of extracellular matrix related genes and significantly reduce oxidative stress levels, decreasing apoptosis of chondrocytes. In animal experiments, Glabridin was observed to alleviate the progression of osteoarthritis and protect chondrocytes from apoptosis.
Letter
Nutrition & Dietetics
Francesco S. Dioguardi
NUTRITION IN CLINICAL PRACTICE
(2021)
Article
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Claudia Romano, Roberto Aquilani, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi
Summary: This article discusses the blood-related issues caused by chronic diseases and treatment strategies for anemia. Emphasis is placed on the need for not only iron supplementation, but also providing all precursor molecules necessary for heme synthesis. Research shows that in elderly anemic patients, implementing personalized treatment strategies including supplementation of essential amino acids and vitamins can lead to a faster increase in hemoglobin levels.
Review
Biochemistry & Molecular Biology
Giovanni Corsetti, Evasio Pasini, Claudia Romano, Carol Chen-Scarabelli, Tiziano M. Scarabelli, Vincenzo Flati, Louis Saravolatz, Francesco S. Dioguardi
Summary: Chronic heart failure is a disease with significant clinical and socio-economic implications, often accompanied by malnutrition and protein disarrangements. Autophagy plays a crucial role in disease progression, with excessive activation potentially leading to cell death and organ failure in patients. Understanding the interplay between nutrition and autophagy could provide important molecular targets for innovative therapeutic strategies in CHF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Giovanni Corsetti, Claudia Romano, Evasio Pasini, Cristian Testa, Francesco S. Dioguardi
Summary: Amino-acids are the main nitrogen source for cells, derived from the breakdown of food proteins absorbed by the small intestine. The quality of food proteins is influenced by Essential-AAs content and digestibility, with limited research on the interaction between undigested proteins and microbiota.
Article
Medicine, General & Internal
Mara Paneroni, Evasio Pasini, Michele Vitacca, Simonetta Scalvini, Laura Comini, Anna Pedrinolla, Massimo Venturelli
Summary: The study revealed that COVID-19 infection significantly impacted blood velocity and femoral blood flow in patients, which may contribute to fatigue, changes in muscle metabolism, and increased cardiovascular risk in long COVID-19 syndrome. Further evaluation is needed to assess the impact of specific treatments such as exercise training, dietary supplements, or drugs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Evasio Pasini, Giovanni Corsetti, Claudia Romano, Tiziano M. Scarabelli, Carol Chen-Scarabelli, Louis Saravolatz, Francesco S. Dioguardi
Summary: Patients with long-Covid syndrome exhibit abnormalities in blood markers related to coagulation, protein disarrangement, and inflammation, indicating ongoing metabolic alterations contributing to the persistence of PASC. Long-term elevated D-Dimer levels suggest potential risks for thromboembolic disease.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Giovanni Corsetti, Claudia Romano, Silvia Codenotti, Evasio Pasini, Alessandro Fanzani, Francesco S. Dioguardi
Summary: A diet rich in essential amino acids can reduce fat accumulation in mice and promote thermogenesis.
Article
Nutrition & Dietetics
Giovanni Corsetti, Claudia Romano, Evasio Pasini, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi
Summary: A diet rich in essential amino acids can protect cardiomyocytes from Doxorubicin-induced damage by increasing mitochondrial generation and reducing oxidative stress, thereby promoting cell survival.
Review
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Francesco Saverio Dioguardi
Summary: Chronic heart failure (CHF) remains a major health problem in industrialized countries, despite therapeutic improvements. Malnutrition, especially protein energy malnutrition, is present in more than half of CHF patients and is an independent predictor of prognosis. Nutritional supplementation and exercise training have been used to treat this condition, but their effectiveness is inconclusive. This paper discusses the molecular mechanisms of specific nutritional supplementation and exercise training that may improve anabolic pathways, particularly focusing on the relationship between exercise and the mTOR complex subunit as Deptor and/or related signaling proteins.
Editorial Material
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Francesco S. S. Dioguardi