Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity

Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice

(2015) Ranu Surolia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neurodegeneration with Brain Iron Accumulation: Genetic Diversity and Pathophysiological Mechanisms

(2015) Esther Meyer et al.   Annual Review of Genomics and Human Genetics

A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation

(2015) Jian-Da Wang et al.   Autophagy

Autophagy and gap junctional intercellular communication inhibition are involved in cadmium-induced apoptosis in rat liver cells

(2015) Hui Zou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy Plays a Cytoprotective Role During Cadmium-Induced Oxidative Damage in Primary Neuronal Cultures

(2015) Tao Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

(2015) Annadurai Anandhan et al.   NEUROBIOLOGY OF DISEASE

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

(2015) Marta Martinez-Vicente   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

(2015) Changyoun Kim et al.   Cell Reports

Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model

(2015) Seongil Jo et al.   International Journal of Environmental Research and Public Health

Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes

(2014) Fang Yuntao et al.   ARCHIVES OF TOXICOLOGY

Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells

(2014) Wu Zhong et al.   Autophagy

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

(2014) Mary C Sheehan et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Toxic Metals and Autophagy

(2014) Sarmishtha Chatterjee et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Low-Level Prenatal Lead Exposure Alters Auditory Recognition Memory in 2-Month-Old Infants: An Event-Related Potentials (ERPs) Study

(2014) Fengji Geng et al.   DEVELOPMENTAL NEUROPSYCHOLOGY

IGF-1 Alleviates NMDA-Induced Excitotoxicity in Cultured Hippocampal Neurons Against Autophagy via the NR2B/PI3K-AKT-mTOR Pathway

(2014) Yansong Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Defective lipid metabolism in neurodegeneration with brain iron accumulation (NBIA) syndromes: not only a matter of iron

(2014) Cristina Colombelli et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Lead exposure at each stage of pregnancy and neurobehavioral development of neonates

(2014) Jian’an Liu et al.   NEUROTOXICOLOGY

Metabolism and functions of copper in brain

(2014) Ivo F. Scheiber et al.   PROGRESS IN NEUROBIOLOGY

Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: A cholinesterase dependent mechanism

(2014) Javier Del Pino et al.   TOXICOLOGY

Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway

(2014) Xue Wei et al.   TOXICOLOGY MECHANISMS AND METHODS

Adaptive changes in autophagy after UPS impairment in Parkinson's disease

(2013) Yu-fei Shen et al.   ACTA PHARMACOLOGICA SINICA

Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium

(2013) Huifeng Pi et al.   Autophagy

Induction of cytoprotective autophagy in PC-12 cells by cadmium

(2013) Qiwen Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

(2013) Susan J. Hayflick et al.   BRAIN

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors

(2013) Teng Jiang et al.   Current Alzheimer Research

Manganese neurotoxicity and the role of reactive oxygen species

(2013) Ebany J. Martinez-Finley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells andDrosophila

(2013) Saera Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle

(2013) M. Sidoryk-Wegrzynowicz et al.   JOURNAL OF INTERNAL MEDICINE

Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells

(2013) Seung-Hee Chang et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Enhanced Brain Delivery of Deferasirox–Lactoferrin Conjugates for Iron Chelation Therapy in Neurodegenerative Disorders: In Vitro and in Vivo Studies

(2013) Golnaz Kamalinia et al.   MOLECULAR PHARMACEUTICS

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Neuronal Autophagy: Self-eating or Self-cannibalism in Alzheimer’s Disease

(2013) Marzena Ułamek-Kozioł et al.   NEUROCHEMICAL RESEARCH

The Role of skn-1 in Methylmercury-Induced Latent Dopaminergic Neurodegeneration

(2013) Ebany J. Martinez-Finley et al.   NEUROCHEMICAL RESEARCH

The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration

(2013) Jianbin Zhang et al.   NEUROTOXICITY RESEARCH

Cadmium-Induced Apoptosis in Primary Rat Cerebral Cortical Neurons Culture Is Mediated by a Calcium Signaling Pathway

(2013) Yan Yuan et al.   PLoS One

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

(2013) G. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

The Genetic Basis for Bacterial Mercury Methylation

(2013) J. M. Parks et al.   SCIENCE

Inhibition of autophagy as a therapeutic strategy of iron-induced brain injury after hemorrhage

(2012) Chiu-Wei Chen et al.   Autophagy

Coordination of Copper to the Membrane-Bound Form of α-Synuclein

(2012) Christopher G. Dudzik et al.   BIOCHEMISTRY

Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and jnk activation

(2012) Cristina Trejo-Solís et al.   BMC CANCER

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Cadmium-induced genetic instability in mice testis

(2012) Helena Oliveira et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury

(2012) Jianbin Zhang et al.   International Journal of Biological Sciences

Lead neurotoxicity: effects on brain nitric oxide synthase

(2012) Concepción Nava-Ruiz et al.   JOURNAL OF MOLECULAR HISTOLOGY

Mitophagy and Parkinson's disease: Be eaten to stay healthy

(2012) Rosa L.A. de Vries et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Brain, blood, and iron: Perspectives on the roles of erythrocytes and iron in neurodegeneration

(2012) Rainer Prohaska et al.   NEUROBIOLOGY OF DISEASE

Astrocyte functions in the copper homeostasis of the brain

(2012) Ivo F. Scheiber et al.   NEUROCHEMISTRY INTERNATIONAL

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

(2012) Marcelo Farina et al.   NEUROCHEMISTRY INTERNATIONAL

Degeneration of peripheral nervous system in rats experimentally induced by methylmercury intoxication

(2012) Bingzhen Cao et al.   NEUROLOGICAL SCIENCES

Effects of environmental contaminant exposure on visual brain development: A prospective electrophysiological study in school-aged children

(2012) Audrey-Anne Ethier et al.   NEUROTOXICOLOGY

Iron and Neurodegeneration: From Cellular Homeostasis to Disease

(2012) Liliana Batista-Nascimento et al.   Oxidative Medicine and Cellular Longevity

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The long history of iron in the Universe and in health and disease

(2011) Alex D. Sheftel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

(2011) Katherine C. M. Chew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death

(2011) Sujuan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives

(2011) Zelda H. Cheung et al.   JOURNAL OF NEUROCHEMISTRY

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Role of manganese in neurodegenerative diseases

(2011) Aaron B. Bowman et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies

(2011) Marcelo Farina et al.   LIFE SCIENCES

Presynaptic malfunction: The neurotoxic effects of cadmium and lead on the proton gradient of synaptic vesicles and glutamate transport

(2011) Tatiana Borisova et al.   NEUROCHEMISTRY INTERNATIONAL

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

(2011) Baoshan Xu et al.   PLoS One

Chelation of Lysosomal Iron Protects Dopaminergic SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide Toxicity by Precluding Autophagy and Akt Dephosphorylation

(2011) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

Cadmium-Induced Autophagy in Rat Kidney: An Early Biomarker of Subtoxic Exposure

(2011) Abderrahman Chargui et al.   TOXICOLOGICAL SCIENCES

Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells

(2011) Young-Ok Son et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells

(2011) Hilary Afeseh Ngwa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Synucleins Are a Family of Redox-Active Copper Binding Proteins

(2010) Paul Davies et al.   BIOCHEMISTRY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

The transition metals copper and iron in neurodegenerative diseases

(2010) Susana Rivera-Mancía et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Molecular Neurobiology of Lead (Pb2+): Effects on Synaptic Function

(2010) April P. Neal et al.   MOLECULAR NEUROBIOLOGY

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

(2010) Peter O Bauer et al.   NATURE BIOTECHNOLOGY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Autophagy involvement in cadmium resistance through induction of multidrug resistance-associated protein and counterbalance of endoplasmic reticulum stress WI38 lung epithelial fibroblast cells

(2010) Sung-Chul Lim et al.   TOXICOLOGY

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

(2010) Shuqiu Zheng et al.   PLoS Genetics

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Parkinson's Disease: From Molecular Pathways in Disease to Therapeutic Approaches

(2009) Bobby Thomas   ANTIOXIDANTS & REDOX SIGNALING

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

(2009) Zhenyu Yue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

ROS-mediated autophagy was involved in cancer cell death induced by novel copper(II) complex

(2009) Wen-jie Guo et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

Copper·Dopamine Complex Induces Mitochondrial Autophagy Preceding Caspase-independent Apoptotic Cell Death

(2009) Irmgard Paris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues

(2009) Hillel Zukor et al.   JOURNAL OF NEUROCHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cadmium Toxicity toward Autophagy through ROS-Activated GSK-3β in Mesangial Cells

(2009) Sheng-Hao Wang et al.   TOXICOLOGICAL SCIENCES

Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway

(2008) S. H. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

(2008) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

(2008) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

(2008) S.A. McDougall et al.   NEUROSCIENCE

Manganese transport in eukaryotes: The role of DMT1

(2008) Catherine Au et al.   NEUROTOXICOLOGY

Progress in the pathogenesis and genetics of Parkinson's disease

(2008) Y. Mizuno et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Promotion of autophagy and inhibition of apoptosis by low concentrations of cadmium in vascular endothelial cells

(2008) Zhiwu Dong et al.   TOXICOLOGY IN VITRO