Article
Polymer Science
Chenmala Karthika, Md. Habibur Rahman, Raman Sureshkumar, Rokeya Akter, Azmat Ali Khan, Amer M. Alanazi, Abul Kalam Azad, Paritosh Barai, Hasi Rani Barai
Summary: This study demonstrates that the use of pectin-coated 5-FU CUR conjugate can effectively manage colorectal cancer induced by TiO2-NPs and DMH in rats.
Article
Pharmacology & Pharmacy
Jie Ge, Ting Liu, Tianxiang Lei, Xuan Li, Kun Song, Samim Azizi, Heli Liu, Mimi Tang
Summary: The study shows that 5-FU implants treatment can improve the 5-year overall survival rate and progression-free survival rate in gastric cancer patients after surgery, with good safety profile.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Evangelos Koustas, Eleni-Myrto Trifylli, Panagiotis Sarantis, Nikolaos I. Kontolatis, Christos Damaskos, Nikolaos Garmpis, Christos Vallilas, Anna Garmpi, Athanasios G. Papavassiliou, Michalis V. Karamouzis
Summary: Gastric cancer is the fifth most common malignancy worldwide and many tumors display resistance to current chemotherapeutic agents. The interplay between gastric cancer development and the autophagy process is crucial, but the role of autophagy as either a tumor suppressor or promoter remains controversial.
Article
Immunology
Zhao-jie An, Yong Li, Bi-bo Tan, Qun Zhao, Li-qiao Fan, Zhi-dong Zhang, Xue-feng Zhao, Shao-yi Li
Summary: The expression level of KLF17 is correlated with tumor characteristics and chemotherapy sensitivity in gastric cancer patients. Upregulation of KLF17 can enhance the sensitivity of GC cell lines to 5-FU, possibly by inhibiting proteins associated with drug resistance and cell proliferation.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Review
Cell Biology
Alireza Mafi, Malihe Rezaee, Neda Hedayati, Sara Diana Hogan, Russel J. Reiter, Mohammad-Hossein Aarabi, Zatollah Asemi
Summary: Combined chemotherapy is an effective treatment for cancer patients, as it combines multiple therapeutic agents to target different aspects of cancer. 5-FU is a widely used chemotherapy agent, while melatonin has shown anti-cancer properties. This review aims to evaluate the role of melatonin as a complementary agent with 5-FU-based chemotherapy and identify their common signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Multidisciplinary
Ting Jiang, Jiaojiao Zhu, Shilong Jiang, Zonglin Chen, Ping Xu, Rong Gong, Changxin Zhong, Yueying Cheng, Xinyuan Sun, Wenjun Yi, Jinming Yang, Wenhu Zhou, Yan Cheng
Summary: In this study, it is discovered that the lncRNA DDIT4-AS1 is highly expressed in TNBC and promotes its progression and chemoresistance by activating autophagy. Mechanistically, DDIT4-AS1 stabilizes DDIT4 mRNA and inhibits the mTOR signaling pathway. Silencing DDIT4-AS1 enhances sensitivity to chemotherapy, and using a self-activatable siRNA/drug nanoparticle system improves antitumor activity. Targeting DDIT4-AS1 may be a new therapeutic approach for TNBC.
Article
Chemistry, Physical
Patrycja Wilczewska, Anna Pancielejko, Justyna Luczak, Malwina Kroczewska, Wojciech Lisowski, Ewa M. Siedlecka
Summary: This study investigated the effect of various ionic liquids on the photocatalytic oxidation of 5-FU and phenol in the presence of TiO2 photocatalysts under artificial sunlight conditions. The presence of ILs enhanced the photoactivity of TiO2 photocatalysts for the removal of cytostatic drugs, with [TBMA][Cl] showing the highest effectiveness. The mechanism of drug degradation varied under different types of light irradiation, highlighting the importance of ILs in improving photocatalytic activity and facilitating hole-electron separation.
APPLIED SURFACE SCIENCE
(2022)
Article
Multidisciplinary Sciences
Qingqing Hu, Jiajia Xu, Jingshu Ke, Ziye Zhang, Ting Chu
Summary: This study assessed the adverse events associated with S-1 and 5-fluorouracil (5-FU) and provided focused healthcare approaches to improve patient compliance and quality of survival. The results showed a higher incidence of stomatitis, hypokalemia, mucosal inflammation, and hypophosphatemia in the 5-FU group compared to the S-1 group.
Article
Medicine, Research & Experimental
Rinad A. Algehani, Raefa Abou Khouzam, Gehan A. Hegazy, Aliaa A. Alamoudi, Ali M. El-Halawany, Riham S. El Dine, Ghada A. Ajabnoor, Fahad A. Al-Abbasi, Mohammed A. Baghdadi, Ibrahim Elsayed, Masao Hattori, Ahmed M. Al-Abd
Summary: A synergistic effect in terms of anticancer properties was observed when colossolactone-G was combined with 5-FU and GCB, influencing both apoptosis and autophagic cell death mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kwan-Ling Yip, Tsen-Ni Tsai, I-Ping Yang, Zhi-Feng Miao, Yen-Cheng Chen, Ching-Chun Li, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Jaw-Yuan Wang
Summary: Metformin enhances the chemosensitivity of colorectal cancer cells to 5-fluorouracil and oxaliplatin by inducing cell cycle arrest and apoptosis through modulation of mitochondria-related proteins.
Review
Biotechnology & Applied Microbiology
Suhana Ahmad, Lidawani Lambuk, Naveed Ahmed, Ali Mussa, Vincent Tee, Ros Akmal Mohd Idris, Nur Fazimah Sahran, Yean Yean Chan, Rosline Hassan, Yeong Yeh Lee, Rohimah Mohamud
Summary: Nab-paclitaxel demonstrates good efficacy and safety in the treatment of metastatic gastric cancer, providing better disease response and longer survival.
Article
Multidisciplinary Sciences
Tianyi Gao, Dan Yuan, Bangshun He, Yingdong Gao, Caidong Liu, Huilin Sun, Junjie Nie, Shukui Wang, Zhenlin Nie
Summary: HSPB8 plays a significant role in CRC 5-FU resistance by acting together with its co-chaperone BAG3 in autophagy-driven resistance. Additionally, the expression level of HSPB8 is significantly correlated with immune cell infiltration.
Article
Biochemistry & Molecular Biology
Jung Ho Han, MinJeong Kim, Hyeon Jin Kim, Se Bok Jang, Sung-Jin Bae, In-Kyu Lee, Dongryeol Ryu, Ki-Tae Ha
Summary: Resistance to anticancer therapeutics is a major challenge in cancer treatment, with altered cancer metabolism, such as the Warburg effect, playing a pivotal role. The use of antiglycolytic agents, such as catechin, may help overcome resistance to 5FU in gastric cancer cells by limiting LDHA expression and lactate production, providing a potential novel adjuvant drug option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma, Lingyu Zhao
Summary: This study demonstrates that MeCP2 confers 5-FU resistance in gastric cancer cells by upregulating the NOX4/PKM2 pathway. Knockdown of MeCP2 enhances the sensitivity of cells to 5-FU, and silencing NOX4 can rescue the inductive effect of MeCP2 overexpression on 5-FU sensitivity. In vivo experiments also show that MeCP2 knockdown enhances 5-FU sensitivity in tumors.
CANCER CELL INTERNATIONAL
(2022)
Article
Engineering, Environmental
Lihui Zhang, Wei Wei, Zixuan Liu, Xuting Liu, Erqun Song, Yang Song
Summary: Research has shown that the decoration of fibrinogen (Fg) on the surface of silica nanoparticles (SiO2 NPs) can attenuate their pro-autophagic activity in non-phagocytic cells; however, this effect is compromised in phagocytic cells. Further investigation revealed that coronal Fg has dual effects on tuning the autophagic response induced by SiO2 NPs.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Immunology
Hamed Haddad Kashani, Hossein Fahimi, Yasaman Dasteh Goli, Rezvan Moniri
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Review
Biotechnology & Applied Microbiology
Hossein Fahimi, Mahshid Mohammadipour, Hamed Haddad Kashani, Farshid Parvini, Majid Sadeghizadeh
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2018)
Article
Plant Sciences
Hassan Rahnama, Haghighat Vakilian, Hossain Fahimi, Behzad Ghareyazie
ACTA PHYSIOLOGIAE PLANTARUM
(2011)
Review
Genetics & Heredity
Sadaf Noavar, Samira Behroozi, Taraneh Tatarcheh, Farshid Parvini, Majid Foroutan, Hossein Fahimi
BMC MEDICAL GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Fatemeh Tahmouresi, Ehsan Razmara, Katayoon Pakravan, Majid Mossahebi-Mohammadi, Fatemeh Rouhollah, Maryam Montazeri, Alireza Sarrafzadeh, Hossein Fahimi, Sadegh Babashah
Summary: The study found significant upregulation of DSCAM-AS1 and MANCR lncRNAs in breast cancer tumor tissues, which were associated with the aggressive clinical parameters of the cancer. The high expressions of these lncRNAs could potentially serve as biomarkers for breast cancer diagnosis and prognosis.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Parisa Ghaffari-Makhmalbaf, Maryam Sayyad, Katayoon Pakravan, Ehsan Razmara, Amirreza Bitaraf, Babak Bakhshinejad, Parmida Goudarzi, Hassan Yousefi, Mahmoud Pournaghshband, Fahimeh Nemati, Hossein Fahimi, Fatemeh Rohollah, Mandana Hasanzad, Mehrdad Hashemi, Seyed Hadi Mousavi, Sadegh Babashah
Summary: The research demonstrates that DHA treatment can inhibit angiogenesis of breast cancer cells by altering the exosomal miRNA contents from pro-angiogenic to anti-angiogenic properties.
Article
Genetics & Heredity
Hossein Fahimi, Samira Behroozi, Sadaf Noavar, Farshid Parvini
Summary: Overall, our study identified a novel homozygous missense mutation in the PDZD7 gene in ARNSHL patients. This expands the spectrum of pathogenic mutations and highlights the clinical importance of genetic counseling and management in these cases.
BMC MEDICAL GENOMICS
(2021)
Article
Oncology
Mohadeseh Haghirizadeh, Donya Yousefi, Hossein Fahimi, Sepideh Khaleghi, Mehrdad Hashemi
Summary: The study aimed to evaluate the expression of A1 FOXA1, FOXA2, SOX10, and GAS2 genes in oral squamous cell carcinoma (OSCC) tumors, showing significant differences in the expression of these genes in tumor and normal tissues. SOX10 and GAS2 genes demonstrated potential as biomarkers for OSCC diagnosis.
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2022)
Article
Genetics & Heredity
Hanie Abolfathi, Mojgan Sheikhpour, Bahram Mohammad Soltani, Hossein Fahimi
Summary: The study evaluated the expression patterns of common miRNAs between TB and NSCLC and compared them with healthy controls. MiR-155 and miR-146a were examined using RT-qPCR, with mir-16 as a reference gene. Bioinformatics analysis confirmed the role of miR-155 and miR-146a in the signaling pathways of TB and NSCLC through targeting related genes. The results showed that miR-155 and miR-146a could serve as biomarkers for early detection, screening, treatment strategies, and clinical management of TB and NSCLC.
Article
Medicine, Research & Experimental
Abolfazl Dehkohneh, Parvaneh Jafari, Hossein Fahimi
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2019)
Review
Health Care Sciences & Services
Bahareh Nowruzi, Setareh Haghighat, Hossein Fahimi, Ehsan Mohammadi
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2018)
Article
Immunology
Hossein Fahimi, Majid Sadeghizadeh, Mahshid Mohammadipour
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH
(2016)
Article
Medicine, Research & Experimental
Hossein Fahimi, Hossein Allahyari, Zuhair M. Hassan, Majid Sadeghizadeh
Iranian Journal of Basic Medical Sciences
(2014)
Article
Biology
Hossein Fahimi, Majid Sadeghizadeh, Zuhair M. Hassan, Heidi Auerswald, Michael Schreiber
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.