Article
Biochemistry & Molecular Biology
Yosuke Tabei, Hiroko Abe, Shingo Suzuki, Nobuaki Takeda, Jun-ichiro Arai, Yoshihiro Nakajima
Summary: This study demonstrated that Sedanolide enhances cellular resistance to oxidative damage through the activation of the KEAP1-NRF2 pathway and upregulation of antioxidant enzymes. Additionally, Sedanolide attenuates cytosolic and mitochondrial ROS generation induced by H2O2, thereby exerting cytoprotective effects against H2O2-induced cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yanling Lin, Qinzhi Zhang, Baofu Xie, Haiyang Jiang, Jianzhong Shen, Shusheng Tang, Chongshan Dai
Summary: In this study, the cytotoxicity of Chelerythrine (CHE) was investigated using human HepG2 cells. The results showed that CHE treatment induced dose-dependent cytotoxicity and oxidative stress in HepG2 cells. Moreover, CHE treatment activated the mitochondrial apoptotic pathway and inhibited the Akt pathway, leading to cell apoptosis. N-acetylcysteine supplementation attenuated CHE-induced cytotoxicity. These findings provide new insights into the toxic mechanisms and health risks of CHE.
Article
Food Science & Technology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: The study demonstrated that protopanaxatriol-type saponin (PTS) effectively protected against acetaminophen (APAP)-induced liver injury by reducing inflammation, oxidative stress, and hepatic apoptosis, and reversing histological changes. Additionally, PTS showed potential as a novel therapeutic agent for APAP-induced liver injury through the ROS-mediated JNK pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agriculture, Multidisciplinary
Yilong Cui, Miao Song, Bonan Xiao, Wanyue Huang, Jian Zhang, Xuliang Zhang, Bing Shao, Yanfei Han, Yanfei Li
Summary: This study demonstrates that aluminum exposure can activate PINK1/Parkin-mediated mitophagy, and this mitophagy plays a protective role in the bone impairment caused by aluminum.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Li Zhou, Chaoqin Zhang, Yu Qiang, Min Huang, Xiangmei Ren, Yuanhong Li, Jihong Shao, Lichun Xu
Summary: The study demonstrated that APSP can protect against lead-induced reproductive toxicity in male mice by attenuating testicular injury, improving sperm count and motility, reducing sperm abnormality rate, restoring antioxidant levels, inhibiting lipid peroxidation, and modulating the JNK signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Huan Li, Qin Yang, Zhen Huang, Cui Liang, Dian-Hong Zhang, Hui-Ting Shi, Jia-Qi Du, Bin-Bin Du, Yan-Zhou Zhang
Summary: Diabetic cardiomyopathy (DCM) is a heart dysfunction that occurs in patients with diabetes mellitus (DM). This study found that dual-specificity phosphatase 12 (DUSP12) plays an important role in DCM. Overexpression of DUSP12 worsens cardiac dysfunction and increases oxidative stress and apoptosis, while DUSP12 deficiency exacerbates these effects. The study also found that DUSP12 interacts with a specific signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Summary: Ivermectin can induce apoptotic cell death in human neuroblastoma cells, promoting ROS production, mitochondrial dysfunction, and autophagy, while inhibiting the Akt/mTOR pathway. Autophagy inhibition improved Ivermectin-induced oxidative stress and apoptotic cell death in these cells.
Article
Environmental Sciences
Mingquan Huang, Xingjie Li, Shengjun Jia, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Summary: The study reveals that BPAF can induce apoptosis of KGN cells in a concentration- and time-dependent manner by increasing the expression of pro-apoptotic proteins and decreasing the expression of anti-apoptotic proteins. Additionally, BPAF exposure leads to a significant increase in intracellular ROS levels, which mediates KGN cell apoptosis through the ROS-ASK1-JNK axis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, Research & Experimental
Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Dehydrocrenatidine has been shown to induce apoptosis in human oral cancer cells through both extrinsic and intrinsic pathways, involving various proteins. Co-treatment with MAPK inhibitors suggests that dehydrocrenatidine induces apoptosis via activation of ERK and JNK signaling pathways. These findings shed light on the potential of dehydrocrenatidine in molecular regulation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Wenying Sun, Huanyi Liu, Huijun Zhu, Meichen Gao, Shiwen Xu
Summary: In this experimental study, the mechanism of TBBPA toxicity on Grass carp hepatocytes (L8824 cells) and the antagonistic impact of EUC on TBBPA were investigated. The results showed that TBBPA exposure induced oxidative stress and activated the ASK1/JNK signaling pathway, resulting in apoptosis. Additionally, EUC effectively protected against TBBPA-induced apoptosis and immune dysfunction by regulating the ROS/ASK1/JNK pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Zunaira Syed, Bushra Shal, Aqsa Azhar, Safa Amanat, Adnan Khan, Hussain Ali, Yun-Seo Kil, Eun Kyoung Seo, Salman Khan
Summary: The present study investigated the effect of xanthoangelol on Alzheimer's disease (AD). Xanthoangelol showed neuroprotective effects and reduced the symptoms of AD by improving signaling pathways, activating antioxidants, attenuating apoptotic pathways, and reducing neuroinflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Zeyneb Chouit, Dounia Djellal, Souhila Haddad, Mourad Hanfer, Messaoud Hachemi, Zhoura Lakroun, Smail Chafaa, Hamadi Fetoui, Mohamed Kebieche, Rachid Soulimani
Summary: The study found that chronic exposure to cadmium may cause changes in neurobehavioral and cognitive abilities in rats, affect mitochondrial function in the brain, increase oxidative stress, and enhance the apoptosis signaling pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zong-Sheng Wu, Hou-Lun Luo, Yao-Chi Chuang, Wei-Chia Lee, Hung-Jen Wang, Michael B. Chancellor
Summary: Platelet-rich plasma (PRP) has been shown to alleviate symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS) by regulating inflammatory processes and promoting tissue repair. This study found that PRP could protect the urothelium during ischemia/hypoxia by decreasing apoptosis through modulating the expression of HIF1 alpha, the mitochondria-mediated intrinsic apoptotic pathway, and reducing ROS.
Article
Pharmacology & Pharmacy
Zhen Qi, Renrong Wang, Rongheng Liao, Song Xue, Yongyi Wang
Summary: Neferine can protect the heart from lipopolysaccharide-induced damage, improve cardiac function, increase survival rate, and alleviate apoptosis and oxidative stress by activating the PI3K/AKT/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Haiyang Chen, Huifen Zhou, Jiehong Yang, Haitong Wan, Yu He
Summary: This study investigated the protective mechanism of Guhong injection (GHI) on myocardial ischemia/reperfusion (MI/R) injury. The results showed that GHI activated glutathione S-transferase P (GST P) to inhibit the ASK1-JNK/p38 pathway, thereby alleviating oxidative stress and apoptosis, and exerting cardioprotective effects.