Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 173, Issue 2, Pages 339-344Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-016-0648-9
Keywords
AlCl3; Kidney; Oxidative stress; Toxicity; Rats
Funding
- National Science Foundation [31172375, 31372496, 31302147]
Ask authors/readers for more resources
This study investigated the toxicity of aluminum chloride (AlCl3) exposure in the rat kidney. Forty male Wistar rats (5 weeks old), weighing 110-120 g, were randomly divided into four groups: control group (CG, 0 g/L AlCl3), low dose group (LG, 0.4 g/L AlCl3), mid dose group (MG, 0.8 g/L AlCl3), and high dose group (HG, 1.6 g/L AlCl3). Rats were administered AlCl3 in their drinking water for 120 days. A variety of measurements were taken including superoxide dismutase (SOD) and glutathione peroxidase (GSH-P-X) activities, malondialdehyde (MDA) concentration in the kidney and blood urea nitrogen (BUN), and cystatin C (Cys-C) concentrations in the serum. In addition, Al and beta(2)-microglobulin (beta(2)-MG) concentrations and the activity of N-acetyl-beta-d-glucosaminidase (NAG) in the urine were determined. The results showed that in the AlCl3-treated groups SOD and GSH-P-X activities were decreased, while NAG activity and Al, MDA, BUN, Cys-C, and beta(2)-MG concentrations were increased, compared with the CG. This study indicates that AlCl3 exposure induces oxidative stress and suppresses kidney function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available