The Amyloid-Beta Clearance: From Molecular Targets to Glial and Neural Cells

FDA approves Alzheimer’s drug lecanemab amid safety concerns

(2023) Sara Reardon   NATURE

Correction to: A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation

(2022) Noah Goshi et al.   Journal of Neuroinflammation

Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease

(2022) Elena Galea et al.   NEUROBIOLOGY OF DISEASE

A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease

(2022) Celia Luchena et al.   Frontiers in Aging Neuroscience

Immunotherapy for Alzheimer’s disease: targeting β-amyloid and beyond

(2022) Chenghuan Song et al.   Translational Neurodegeneration

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

(2022) Julia TCW et al.   CELL

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

(2022) Matheus B. Victor et al.   Cell Stem Cell

Microglial amyloid beta clearance is driven by PIEZO1 channels

(2022) Henna Jäntti et al.   Journal of Neuroinflammation

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease

(2022) João Pedro Ferrari-Souza et al.   MOLECULAR PSYCHIATRY

Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures

(2022) Ari Ogaki et al.   Frontiers in Cellular Neuroscience

The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism

(2022) Hui-Zhi Long et al.   Frontiers in Aging Neuroscience

Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease

(2022) Micaela E. Consens et al.   Frontiers in Molecular Neuroscience

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

(2022) Hannah Ennerfelt et al.   CELL

A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer’s disease

(2022) Marcella Catania et al.   MOLECULAR PSYCHIATRY

Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

(2022) Ashley N. Brandebura et al.   NATURE REVIEWS NEUROSCIENCE

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

(2022) Fumito Endo et al.   SCIENCE

Synaptogenic effect of APP -Swedish mutation in familial Alzheimer’s disease

(2022) Bo Zhou et al.   Science Translational Medicine

A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease

(2022) Peng Zhao et al.   Science Translational Medicine

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

(2021) Marvin Reich et al.   Frontiers in Immunology

Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

(2021) Daniel M. Ramos et al.   NEURON

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

(2021) Jong-Sung Park et al.   Acta Neuropathologica Communications

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

(2021) Jinar Rostami et al.   Journal of Neuroinflammation

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

(2021) Christel Claes et al.   Molecular Neurodegeneration

The Amyloid-β Pathway in Alzheimer’s Disease

(2021) Harald Hampel et al.   MOLECULAR PSYCHIATRY

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

(2021) Hao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

(2021) Jiwen Li et al.   Nature Communications

Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers

(2021) Ladan Amin et al.   Nature Communications

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

(2021) Reina Bassil et al.   Nature Communications

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

(2021) Katharina Cosker et al.   Scientific Reports

Alzheimer’s Disease: A Molecular View of β-Amyloid Induced Morbific Events

(2021) Rajmohamed Mohamed Asik et al.   Biomedicines

Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures

(2021) Laura Tapella et al.   CELL CALCIUM

Alzheimer’s disease clinical trial update 2019–2021

(2021) Joseph Pleen et al.   JOURNAL OF NEUROLOGY

Microglia contribute to the propagation of Aβ into unaffected brain tissue

(2021) Paolo d’Errico et al.   NATURE NEUROSCIENCE

TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease

(2021) Seung-Hye Lee et al.   Cell Reports

Characterization of Alzheimer’s Disease-Associated Excitatory Neurons via Single-Cell RNA Sequencing Analysis

(2021) Fanghong Shao et al.   Frontiers in Aging Neuroscience

Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2020) Iris E. Jansen et al.   NATURE GENETICS

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease

(2020) Courtney M. Kloske et al.   Frontiers in Immunology

Using amyloid PET imaging to diagnose Alzheimer’s disease in patients with multiple sclerosis

(2020) Magdalena Kolanko et al.   JOURNAL OF NEUROLOGY

Functional and transcriptional characterization of complex neuronal co-cultures

(2020) Heather A. Enright et al.   Scientific Reports

ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease

(2020) Maria Fe Lanfranco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease

(2020) Yuanming Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection

(2020) Madeleine R. Brown et al.   Frontiers in Molecular Neuroscience

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

(2019) Michaël E. Belloy et al.   NEURON

Cognitive changes of older adults with an equivocal amyloid load

(2019) Kristell Pothier et al.   JOURNAL OF NEUROLOGY

GABAergic astrocytes in Alzheimer’s disease

(2019) Olga Garaschuk et al.   Aging-US

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Human iPSC application in Alzheimer’s disease and Tau-related neurodegenerative diseases

(2019) Julia TCW   NEUROSCIENCE LETTERS

The molecular lifecycle of amyloid – Mechanism of assembly, mesoscopic organisation, polymorphism, suprastructures, and biological consequences

(2019) Liisa Lutter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

(2019) Jorge L. Del-Aguila et al.   Alzheimers Research & Therapy

Diagnosis and Management of Dementia: Review

(2019) Zoe Arvanitakis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

(2019) Hailan Yao et al.   Frontiers in Cellular Neuroscience

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

(2018) Marc Fakhoury   Current Neuropharmacology

HDL Mimetic Peptide 4F Mitigates Aβ-Induced Inhibition of ApoE Secretion and Lipidation in Primary Astrocytes and Microglia

(2018) Dustin Chernick et al.   JOURNAL OF NEUROCHEMISTRY

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

(2018) Paul J. Cheng-Hathaway et al.   Molecular Neurodegeneration

Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease

(2018) Jennifer N.K. Nyarko et al.   NEUROSCIENCE

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

(2018) Victoria Navarro et al.   Frontiers in Aging Neuroscience

Ca2+, Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases

(2018) Pradoldej Sompol et al.   Frontiers in Aging Neuroscience

Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis

(2018) Wenting Qu et al.   Frontiers in Immunology

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

(2018) Jerome Mertens et al.   Annual Review of Genetics

Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model

(2018) Xin Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

(2018) Serena Pavoni et al.   PLoS One

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

(2018) Kelly Ceyzériat et al.   Acta Neuropathologica Communications

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

(2017) Shane M. Bemiller et al.   Molecular Neurodegeneration

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

In vivo staging of regional amyloid deposition

(2017) Michel J. Grothe et al.   NEUROLOGY

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

(2017) Tien-Phat V. Huynh et al.   NEURON

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study

(2017) Laura Cantu’ et al.   Scientific Reports

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Astroglia dynamics in ageing and Alzheimer's disease

(2016) Alexei Verkhratsky et al.   CURRENT OPINION IN PHARMACOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

Assessment of the genetic variance of late-onset Alzheimer's disease

(2016) Perry G. Ridge et al.   NEUROBIOLOGY OF AGING

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway?

(2016) Kelly Ceyzériat et al.   NEUROSCIENCE

Neuro-immune interactions across development: A look at glutamate in the prefrontal cortex

(2016) Victoria A. Macht   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Phosphorylation modifies the molecular stability of β-amyloid deposits

(2016) Nasrollah Rezaei-Ghaleh et al.   Nature Communications

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation

(2016) Elsa Vera et al.   Cell Reports

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease

(2016) David S. Bouvier et al.   Scientific Reports

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

(2015) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease

(2015) Soumitra Ghosh et al.   EBioMedicine

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Dementia in older people: an update

(2014) D. LoGiudice et al.   INTERNAL MEDICINE JOURNAL

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β

(2013) Toshihiko Sugiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Peripherally Applied Synthetic Peptide isoAsp7-Aβ(1-42) Triggers Cerebral β-Amyloidosis

(2013) S. A. Kozin et al.   NEUROTOXICITY RESEARCH

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Mapping the Road Forward in Alzheimer's Disease

(2011) D. M. Holtzman et al.   Science Translational Medicine

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY