Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

(2022) Hiruy S. Meharena et al.   Cell Stem Cell

Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells

(2021) Ting Lu et al.   JOURNAL OF IMMUNOLOGY

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

(2021) Guoyuan Qi et al.   Cell Reports

Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation

(2021) Maria Fe Lanfranco et al.   GLIA

Long-term maturation of human cortical organoids matches key early postnatal transitions

(2021) Aaron Gordon et al.   NATURE NEUROSCIENCE

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

(2021) Grzegorz Sienski et al.   Science Translational Medicine

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease

(2021) Kelly A. Zalocusky et al.   NATURE NEUROSCIENCE

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

(2021) Ruilin Tian et al.   NATURE NEUROSCIENCE

Structural insights into GIRK2 channel modulation by cholesterol and PIP2

(2021) Yamuna Kalyani Mathiharan et al.   Cell Reports

Neurotoxic reactive astrocytes induce cell death via saturated lipids

(2021) Kevin A. Guttenplan et al.   NATURE

Synapse development is regulated by microglial THIK-1 K+ channels

(2021) Pablo Izquierdo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Lipid and Lipoprotein Metabolism in Microglia

(2020) Bailey A. Loving et al.   Frontiers in Physiology

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

(2020) Clotilde Lauro et al.   Frontiers in Immunology

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development

(2020) Florian Renoux et al.   Cell Reports

Microglial calcium signaling is attuned to neuronal activity in awake mice

(2020) Anthony D Umpierre et al.   eLife

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia

(2020) Gun-Hoo Park et al.   NATURE NEUROSCIENCE

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism

(2020) Lucas Cheadle et al.   NEURON

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

(2020) Mario Merlini et al.   NATURE NEUROSCIENCE

CD36 in Alzheimer’s Disease: An Overview of Molecular Mechanisms and Therapeutic Targeting

(2020) Ana-Maria Dobri et al.   NEUROSCIENCE

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

(2019) Brandon Farmer et al.   Cells

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Neuroinflammation and fractalkine signaling in Alzheimer’s disease

(2019) Dylan J. Finneran et al.   Journal of Neuroinflammation

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

(2019) Henna Konttinen et al.   Stem Cell Reports

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K + Channel THIK-1

(2018) Christian Madry et al.   NEURON

Generation and assembly of human brain region–specific three-dimensional cultures

(2018) Steven A. Sloan et al.   Nature Protocols

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury

(2018) Marina Colella et al.   Frontiers in Neurology

Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels

(2018) Anna N. Bukiya et al.   JOURNAL OF LIPID RESEARCH

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

Reliability of human cortical organoid generation

(2018) Se-Jin Yoon et al.   NATURE METHODS

Microglia and the Purinergic Signaling System

(2018) Stefano Calovi et al.   NEUROSCIENCE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus

(2017) Anna N. Bukiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcriptional repressor HIC1 regulates intestinal immune homeostasis

(2017) K Burrows et al.   Mucosal Immunology

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages

(2014) Konstantin Tsoyi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Rapid Temporal Dynamics of Transcription, Protein Synthesis, and Secretion during Macrophage Activation

(2014) Katrin Eichelbaum et al.   MOLECULAR & CELLULAR PROTEOMICS

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

(2014) Dirk Heckl et al.   NATURE BIOTECHNOLOGY

Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

(2014) Matheus B. Victor et al.   NEURON

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

The isolectin IB4 binds RET receptor tyrosine kinase in microglia

(2013) Francesca Boscia et al.   JOURNAL OF NEUROCHEMISTRY

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

(2010) Jessica M. Ellis et al.   Cell Metabolism

Cholesterol reduction impairs exocytosis of synaptic vesicles

(2010) A. Linetti et al.   JOURNAL OF CELL SCIENCE

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Ion channels to inactivate neurons in Drosophila

(2009) James J. L. Hodge   Frontiers in Molecular Neuroscience