Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
Published 2022 View Full Article
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Title
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
Authors
Keywords
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Journal
CELL
Volume 185, Issue 13, Pages 2213-2233.e25
Publisher
Elsevier BV
Online
2022-06-23
DOI
10.1016/j.cell.2022.05.017
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Note: Only part of the references are listed.- APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
- (2021) Grzegorz Sienski et al. Science Translational Medicine
- Integration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
- (2021) Gloriia Novikova et al. Nature Communications
- Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
- (2021) Jerome Mertens et al. Cell Stem Cell
- Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH
- (2021) Daniel M. Ramos et al. NEURON
- Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
- (2021) Chao Wang et al. NEURON
- Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes
- (2021) Jiwen Li et al. Nature Communications
- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
- (2020) Yingyue Zhou et al. NATURE MEDICINE
- TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
- (2020) Alicia A. Nugent et al. NEURON
- Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program
- (2020) Laufey Geirsdottir et al. CELL
- APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
- (2020) Axel Montagne et al. NATURE
- Disease-associated astrocytes in Alzheimer’s disease and aging
- (2020) Naomi Habib et al. NATURE NEUROSCIENCE
- Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways
- (2020) Na Zhao et al. NEURON
- dream: Powerful differential expression analysis for repeated measures designs
- (2020) Gabriel E Hoffman et al. BIOINFORMATICS
- Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
- (2020) Joel W. Blanchard et al. NATURE MEDICINE
- Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
- (2020) Benjamin J. Andreone et al. NATURE NEUROSCIENCE
- Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
- (2020) Karpagam Srinivasan et al. Cell Reports
- Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting
- (2019) Kathryn R. Bowles et al. PLoS One
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Multiplexing protein and gene level measurements on a single Luminex platform
- (2019) Damon B. Cook et al. METHODS
- A gas chromatography–mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis
- (2019) Christoph Müller et al. Nature Protocols
- ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components
- (2019) Yu Yamazaki et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- (2018) Paul A. Parcon et al. Alzheimers & Dementia
- APOE -ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies
- (2018) Usman Saeed et al. Alzheimers & Dementia
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
- (2018) Chengzhong Wang et al. NATURE MEDICINE
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
- (2018) Yuan-Ta Lin et al. NEURON
- Brain Cell Type Specific Gene Expression and Co-expression Network Architectures
- (2018) Andrew T. McKenzie et al. Scientific Reports
- The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
- (2018) Minghui Wang et al. Scientific Data
- A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research
- (2018) Philip L. De Jager et al. Scientific Data
- Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
- (2018) Farid Rajabli et al. PLoS Genetics
- Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
- (2018) Celina Monteiro Abreu et al. Frontiers in Microbiology
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells
- (2017) Nina H. Pipalia et al. JOURNAL OF LIPID RESEARCH
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
- (2017) Thais F Galatro et al. NATURE NEUROSCIENCE
- iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
- (2017) Edsel M. Abud et al. NEURON
- Taming Human Genetic Variability: Transcriptomic Meta-Analysis Guides the Experimental Design and Interpretation of iPSC-Based Disease Modeling
- (2017) Pierre-Luc Germain et al. Stem Cell Reports
- An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells
- (2017) Julia TCW et al. Stem Cell Reports
- The extracellular matrix: Tools and insights for the “omics” era
- (2016) Alexandra Naba et al. MATRIX BIOLOGY
- Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
- (2016) Dominik Paquet et al. NATURE
- Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
- (2016) Ye Zhang et al. NEURON
- Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
- (2016) Minghui Wang et al. Genome Medicine
- Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export
- (2016) Jian Li et al. eLife
- Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets
- (2016) Egor Dzyubenko et al. NEURAL PLASTICITY
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
- (2015) Cedric Bardy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Second-generation PLINK: rising to the challenge of larger and richer datasets
- (2015) Christopher C Chang et al. GigaScience
- Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
- (2014) S. Kim et al. GENOME RESEARCH
- Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
- (2014) K Brennand et al. MOLECULAR PSYCHIATRY
- APOE 4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory
- (2014) G. A. Kerchner et al. NEUROLOGY
- Apolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis
- (2014) Mengying Liu et al. Scientific Reports
- A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
- (2014) Ethan S. Lippmann et al. Scientific Reports
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- Causal analysis approaches in Ingenuity Pathway Analysis
- (2013) Andreas Krämer et al. BIOINFORMATICS
- Digital sorting of complex tissues for cell type-specific gene expression profiles
- (2013) Yi Zhong et al. BMC BIOINFORMATICS
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- 25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line
- (2013) Sabine Waltl et al. NEUROSCIENCE LETTERS
- Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics
- (2013) Lisa Buvall et al. Nature Communications
- National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
- (2012) Bradley T. Hyman et al. Alzheimers & Dementia
- Roles for Actin Assembly in Endocytosis
- (2012) Olivia L. Mooren et al. Annual Review of Biochemistry
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
- (2012) Ethan S Lippmann et al. NATURE BIOTECHNOLOGY
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
- (2011) Thomas J. Montine et al. ACTA NEUROPATHOLOGICA
- A novel potent synthetic steroidal liver X receptor agonist lowers plasma cholesterol and triglycerides and reduces atherosclerosis in LDLR-/- mice
- (2011) Dacheng Peng et al. BRITISH JOURNAL OF PHARMACOLOGY
- Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
- (2011) L. Lapasset et al. GENES & DEVELOPMENT
- Synthetic spike-in standards for RNA-seq experiments
- (2011) L. Jiang et al. GENOME RESEARCH
- Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
- (2011) Miri Gitik et al. Journal of Neuroinflammation
- The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices
- (2011) Alexandra Naba et al. MOLECULAR & CELLULAR PROTEOMICS
- APOE and Alzheimer disease: a major gene with semi-dominant inheritance
- (2011) E Genin et al. MOLECULAR PSYCHIATRY
- Integrative genomics viewer
- (2011) James T Robinson et al. NATURE BIOTECHNOLOGY
- Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain
- (2011) Alexandre Kuhn et al. NATURE METHODS
- Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts
- (2011) N. H. Pipalia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomal Lipid Storage Diseases
- (2011) H. Schulze et al. Cold Spring Harbor Perspectives in Biology
- IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
- (2011) C Barcia et al. Cell Death & Disease
- Molecular Mechanism of Cyclodextrin Mediated Cholesterol Extraction
- (2011) Cesar A. López et al. PLoS Computational Biology
- Development of a Cell-Based, High-Throughput Screening Assay for Cholesterol Efflux Using a Fluorescent Mimic of Cholesterol
- (2010) Jun Zhang et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Hem-1: Putting the “WAVE” into actin polymerization during an immune response
- (2010) Heon Park et al. FEBS LETTERS
- MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
- (2010) Yun Li et al. GENETIC EPIDEMIOLOGY
- TNFα and IFNγ Synergistically Enhance Transcriptional Activation ofCXCL10in Human Airway Smooth Muscle Cells via STAT-1, NF-κB, and the Transcriptional Coactivator CREB-binding Protein
- (2010) Deborah L. Clarke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell type–specific gene expression differences in complex tissues
- (2010) Shai S Shen-Orr et al. NATURE METHODS
- ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
- (2010) Y. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The extracellular matrix in development and morphogenesis: A dynamic view
- (2009) Tania Rozario et al. DEVELOPMENTAL BIOLOGY
- Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb
- (2009) K. Schmidt et al. MOLECULAR AND CELLULAR BIOLOGY
- WGCNA: an R package for weighted correlation network analysis
- (2008) Peter Langfelder et al. BMC BIOINFORMATICS
- Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
- (2008) Michael S. Brown et al. JOURNAL OF LIPID RESEARCH
- Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
- (2008) D. R. Riddell et al. JOURNAL OF NEUROSCIENCE
- Genotype, haplotype and copy-number variation in worldwide human populations
- (2008) Mattias Jakobsson et al. NATURE
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