Synaptogenic effect of APP -Swedish mutation in familial Alzheimer’s disease

Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease

(2021) Reisa Sperling et al.   JAMA Neurology

Alzheimer disease

(2021) David S. Knopman et al.   Nature Reviews Disease Primers

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

(2021) Stephen Salloway et al.   NATURE MEDICINE

Revisiting FDA Approval of Aducanumab

(2021) G. Caleb Alexander et al.   NEW ENGLAND JOURNAL OF MEDICINE

The β-secretase BACE1 in Alzheimer’s disease

(2020) Harald Hampel et al.   BIOLOGICAL PSYCHIATRY

Amyloid Beta Secreted during Consolidation Prevents Memory Malleability

(2020) Peter S.B. Finnie et al.   CURRENT BIOLOGY

Amyloid‐β oligomers in cellular models of Alzheimer’s disease

(2020) Igor C. Fontana et al.   JOURNAL OF NEUROCHEMISTRY

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

(2020) Timothy J. Hark et al.   Cell Systems

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease

(2019) David Henley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

(2019) Yu-Wen Alvin Huang et al.   JOURNAL OF NEUROSCIENCE

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

(2019) Swagata Ghatak et al.   eLife

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease

(2019) Heinz Hillen   Frontiers in Neuroscience

Knockout of Amyloid β Protein Precursor (APP) Expression Alters Synaptogenesis, Neurite Branching and Axonal Morphology of Hippocampal Neurons

(2018) Katherine A. Southam et al.   NEUROCHEMICAL RESEARCH

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease

(2018) Mehdi Jorfi et al.   Scientific Reports

Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1–42synaptotoxicity

(2017) Xiaoyi Qu et al.   JOURNAL OF CELL BIOLOGY

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

(2017) Zemin Wang et al.   JOURNAL OF NEUROSCIENCE

The Exceptional Vulnerability of Humans to Alzheimer’s Disease

(2017) Lary C. Walker et al.   TRENDS IN MOLECULAR MEDICINE

Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization

(2017) Yusuke Naito et al.   Scientific Reports

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

(2016) Carlo Sala Frigerio et al.   Annual Review of Neuroscience

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells

(2016) Alison E. Mungenast et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

(2016) Ming Lei et al.   NEUROBIOLOGY OF DISEASE

Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer’s Disease Model

(2016) Lena C. Schmid et al.   NEURON

Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

(2016) Niels R. Reinders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons

(2016) F. Yi et al.   SCIENCE

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1

(2015) ChangHui Pak et al.   Cell Stem Cell

Analysis of conditional heterozygous STXBP1 mutations in human neurons

(2015) Christopher Patzke et al.   JOURNAL OF CLINICAL INVESTIGATION

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A  Pharmacodynamic Responses in Mice, Dogs, and Humans

(2015) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

(2015) Steven Moore et al.   Cell Reports

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease

(2011) C. Perez-Cruz et al.   JOURNAL OF NEUROSCIENCE

Presenilins in synaptic function and disease

(2011) Angela Ho et al.   TRENDS IN MOLECULAR MEDICINE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA