Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement

Effects of plants-associated microbiota on cultivation and quality of Chinese herbal medicines

(2023) Yue Ouyang et al.   Chinese Herbal Medicines

Cucurbitacins and the Immune System: Update in Research on Anti-inflammatory, Antioxidant, and Immunomodulatory Mechanisms

(2022) Geovana F. Guedes Silvestre et al.   CURRENT MEDICINAL CHEMISTRY

Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice

(2022) Jin Zhang et al.   MEDIATORS OF INFLAMMATION

Cucurbitacin B inhibits TGF-β1-induced epithelial–mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways

(2022) Renyikun Yuan et al.   Chinese Medicine

Cucurbitacin E inhibits cellular proliferation and induces apoptosis in melanoma by suppressing HSDL2 expression

(2022) Wen-Bei Liu et al.   Chinese Medicine

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway

(2022) Jinlian Wei et al.   Acta Pharmaceutica Sinica B

Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy

(2022) Tingting Chen et al.   International Journal of Nanomedicine

Anti-Diabetic Effects of Cucurbitacins from Ibervillea lindheimeri on Induced Mouse Diabetes

(2022) Sonia E. Hernández Navia et al.   Journal of Chemistry

Molecular Mechanisms behind Safranal’s Toxicity to HepG2 Cells from Dual Omics

(2022) David Roy Nelson et al.   Antioxidants

Cucurbitacin-B Exerts Anticancer Effects through Instigation of Apoptosis and Cell Cycle Arrest within Human Prostate Cancer PC3 Cells via Downregulating JAK/STAT Signaling Cascade

(2022) Ahmed Alafnan et al.   Pharmaceuticals

Preparation, characterization and pharmacokinetics of Cucurbitacin B solid dispersion

(2022) Qian Wu et al.   OpenNano

Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches

(2022) Suzan Abdu et al.   MOLECULES

Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders

(2021) Bahare Salehi et al.   PHYTOTHERAPY RESEARCH

Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis

(2021) Baodan Yu et al.   Molecular Medicine Reports

Cucurbitacin B Inhibits Cell Proliferation by Regulating X-Inactive Specific Transcript Expression in Tongue Cancer

(2021) Boqiang Tao et al.   Frontiers in Oncology

Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis

(2021) Jian-Hua Liu et al.   PHARMACEUTICAL BIOLOGY

The Mechanisms of Cucurbitacin E as a Neuroprotective and Memory-Enhancing Agent in a Cerebral Hypoperfusion Rat Model: Attenuation of Oxidative Stress, Inflammation, and Excitotoxicity

(2021) Zhiyong Liu et al.   Frontiers in Pharmacology

Cucurbitacin E Inhibits Huh7 Hepatoma Carcinoma Cell Proliferation and Metastasis via Suppressing MAPKs and JAK/STAT3 Pathways

(2020) Yang Liu et al.   MOLECULES

Novel Mechanistic Insight into the Anticancer Activity of Cucurbitacin D against Pancreatic Cancer (Cuc D Attenuates Pancreatic Cancer)

(2020) Mohammed Sikander et al.   Cells

Cucurbitacin B supplementation reduces inflammatory responses and alveolar bone loss via regulating MPO, COX-2 and RANK/RANKL/OPG signals in a rodent model of ligature-induced periodontitis

(2020) Huilan Zhong et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Vegetables from Cucurbitaceae family and their products; positive effect on human health

(2020) Agata Rolnik et al.   NUTRITION

Phytochemical Analysis and Antioxidant and Anti-Inflammatory Capacity of the Extracts of Fruits of the Sechium Hybrid

(2020) Itzen Aguiñiga-Sánchez et al.   MOLECULES

Cucurbitacin E Induces Autophagy-Involved Apoptosis in Intestinal Epithelial Cells

(2020) Huapei Song et al.   Frontiers in Physiology

Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway

(2020) Yuan Liang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Hawthorn Herbal Preparation from Crataegus oxyacantha Attenuates In Vivo Carbon Tetrachloride -Induced Hepatic Fibrosis via Modulating Oxidative Stress and Inflammation

(2020) Alaaeldin Ahmed Hamza et al.   Antioxidants

Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

(2019) Pengfei Liu et al.   MOLECULES

Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone

(2019) Ru-Qiang Yuan et al.   HYPERTENSION RESEARCH

Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats

(2019) Natthaphon Hunsakunachai et al.   BMC Complementary and Alternative Medicine

In Vitro and In Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product From Cucumber

(2019) Dinglan Wu et al.   Frontiers in Pharmacology

Cucurbitacin B inhibits tumor angiogenesis by triggering the mitochondrial signaling pathway in endothelial cells

(2018) Xian-Mei Piao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cucurbitacin I induces pro-death autophagy in A549 cells via the ERK-mTOR-STAT3 signaling pathway

(2018) Yinyun Ni et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A new sensitive UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma: application to an absolute bioavailability study

(2018) Ya Xiao et al.   RSC Advances

Cucurbitacin E Inhibits Proliferation and Migration of Intestinal Epithelial Cells via Activating Cofilin

(2018) Huapei Song et al.   Frontiers in Physiology

Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells

(2018) Yanting Chai et al.   MEDICAL SCIENCE MONITOR

Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review)

(2017) Sukant Garg et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy

(2017) Yang Xiao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanistic investigation of hepato-protective potential for cucurbitacins

(2017) Hajer M. Arjaibi et al.   MEDICINAL CHEMISTRY RESEARCH

The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway

(2017) Xueqiang Zhu et al.   Molecular Medicine Reports

Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells

(2017) Xuewen Liu et al.   ONCOLOGY REPORTS

Cucurbitacin B inhibits cell proliferation and induces apoptosis in human osteosarcoma cells via modulation of the JAK2/STAT3 and MAPK pathways

(2017) Zhi-Ren Zhang et al.   Experimental and Therapeutic Medicine

Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis

(2016) Sonam Sinha et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway

(2016) You-Li Xie et al.   Experimental and Therapeutic Medicine

The role of EMT and MET in cancer dissemination

(2015) Jacqueline Banyard et al.   CONNECTIVE TISSUE RESEARCH

Inhibition of HER2-Integrin signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression

(2015) Parul Gupta et al.   Oncotarget

Antiangiogenic effects of cucurbitacin-I

(2014) Hyeon Jin Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth

(2014) Yajuan Gao et al.   CANCER LETTERS

Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer

(2014) Hyeon Jin Kim et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cucurbitacin I Induces Protective Autophagy in Glioblastomain Vitroandin Vivo

(2014) Guang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH-SY5Y human neuroblastoma cells

(2014) QIAN ZHENG et al.   Molecular Medicine Reports

Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner

(2014) Jiajie Guo et al.   PLoS One

Cucurbitacin B potently suppresses non-small-cell lung cancer growth: Identification of intracellular thiols as critical targets

(2013) Hina Kausar et al.   CANCER LETTERS

Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages

(2013) Jian He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Biological activities and potential molecular targets of cucurbitacins

(2012) Xiuping Chen et al.   ANTI-CANCER DRUGS

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation

(2012) Suwit Duangmano et al.   BMC Complementary and Alternative Medicine

Cucurbitacins as Inducers of Cell Death and a Rich Source of Potential Anticancer Compounds

(2012)   CURRENT PHARMACEUTICAL DESIGN

IntroducingCichorium Pumilumas a Potential Therapeutical Agent Against Drug-Induced Benign Breast Tumor in Rats

(2012) M-Ali H. Al-Akhras et al.   ELECTROMAGNETIC BIOLOGY AND MEDICINE

Cucurbitacin E Induces G2/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes ApoptosisviaFas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells

(2012) Wen-Wen Huang et al.   Evidence-based Complementary and Alternative Medicine

Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells

(2012) Terukazu Ishii et al.   TUMOR BIOLOGY

Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells

(2011) Y. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation

(2011) C Boykin et al.   BRITISH JOURNAL OF CANCER

Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells

(2011) Han-Shui Hsu et al.   CANCER

Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition

(2011) Siddig Ibrahim Abdelwahab et al.   FITOTERAPIA

The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2α in leukemia cells

(2010) Yanchun Li et al.   ANTI-CANCER DRUGS

Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer

(2010) Gabriela B Iwanski et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity In vitro and In vivo

(2010) S. Banerjee et al.   CANCER RESEARCH

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway

(2010) Y. Dong et al.   CARCINOGENESIS

Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin

(2010) Tingyan Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis

(2010) G. Ishdorj et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Pancreatic Cancer Cell Growth by Cucurbitacin B Through Modulation of Signal Transducer and Activator of Transcription 3 Signaling

(2010) Meixia Zhang et al.   PANCREAS

Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

(2009) Kin Tak Chan et al.   CANCER LETTERS

Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

(2009) N. H. Thoennissen et al.   CANCER RESEARCH

Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells

(2009) Vivian W.Y. Lui et al.   CARCINOGENESIS

Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro

(2009) Norito Takahashi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cucurbitacin B induces G2arrest and apoptosisviaa reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells

(2009) Shusuke Yasuda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B

(2008) Meixia Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer

(2008) Tingyan Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells

(2008) Talin Haritunians et al.   LEUKEMIA RESEARCH