Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

Increase in CIP2A expression is associated with cisplatin chemoresistance in gastric cancer

(2018) Juanli Ji et al.   Cancer Biomarkers

Enhanced glycolysis supports cell survival in EGFR-mutant lung adenocarcinoma by inhibiting autophagy-mediated EGFR degradation

(2018) Ji Hye Kim et al.   CANCER RESEARCH

Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors

(2018) Cecilia Lopez Sambrooks et al.   CANCER RESEARCH

The Domino Effect in EGFR-ERK Signaling

(2018) Udi Binshtok et al.   DEVELOPMENTAL CELL

Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A

(2018) Lan Jin et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer

(2018) Xuewen Liu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antagonizing SET augments the effects of radiotherapy in hepatocellular carcinoma through reactivating PP2A-mediated AKT downregulation

(2018) Chao-Yuan Huang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme

(2018) Shanshan Qin et al.   MOLECULAR CARCINOGENESIS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer

(2018) Jianhua Mao et al.   Cell Death & Disease

Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A

(2017) Qiuyue Huang et al.   ONCOLOGY REPORTS

High expression of CIP2A protein is associated with tumor aggressiveness in stage I–III NSCLC and correlates with poor prognosis

(2017) Geqi Cha et al.   OncoTargets and Therapy

Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells

(2016) Naghma Khan et al.   CARCINOGENESIS

Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways

(2016) XIANGLING XIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/Adriamycin cells

(2016) Fen Cai et al.   ONCOLOGY REPORTS

Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy

(2016) Shan Li et al.   Oncology Letters

MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in non-small cell lung cancer

(2016) Jing Wen et al.   Oncotarget

Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy

(2016) Tingting Feng et al.   Oncotarget

Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis

(2016) Samriddhi Shukla et al.   Scientific Reports

Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis

(2015) S. Shukla et al.   Cancer Prevention Research

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

(2015) Jaya Sangodkar et al.   FEBS Journal

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

(2015) Hao Liu et al.   Oncotarget

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis

(2015) Jiujiao Gao et al.   Oncotarget

PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects

(2015) Raúl Rincón et al.   Oncotarget

Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells

(2015) Wei Cao et al.   Scientific Reports

Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands

(2015) Pradip De et al.   Oncotarget

Cucurbitacin B Induces DNA Damage, G2/M Phase Arrest, and Apoptosis Mediated by Reactive Oxygen Species (ROS) in Leukemia K562 Cells

(2014) Jiajie Guo et al.   Anti-Cancer Agents in Medicinal Chemistry

Cucurbitacin B potently suppresses non-small-cell lung cancer growth: Identification of intracellular thiols as critical targets

(2013) Hina Kausar et al.   CANCER LETTERS

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

(2013) Parthasarathy Seshacharyulu et al.   CANCER LETTERS

Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer

(2013) Zi Liu et al.   CARCINOGENESIS

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

Fucosyltransferase IV Enhances Expression of MMP-12 Stimulated by EGF via the ERK1/2, p38 and NF-kB Pathways in A431Cells

(2012) Xue-Song Yang et al.   Asian Pacific Journal of Cancer Prevention

Interpopulation hybridization results in widespread viability selection across the genome in Tigriopus californicus

(2011) Victoria L Pritchard et al.   BMC GENETICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer

(2011) Liang Ma et al.   PLoS One

Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration

(2010) Kin Tak Chan et al.   CANCER LETTERS

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA