Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway

Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat

(2021) Ruoxi Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential

(2021) Shuai Huang et al.   Cell Death & Disease

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

(2021) Keting Bao et al.   Cell Death & Disease

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species

(2021) Zhifan Mao et al.   Acta Pharmaceutica Sinica B

Conjunctival Melanoma: Current Treatments and Future Options

(2020) Joseph M. Grimes et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity

(2020) Jiaxin Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway

(2020) Prasad Dandawate et al.   Scientific Reports

Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma

(2020) Slavisa Ninkovic et al.   Expert Review of Hematology

A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1

(2020) Zhenghui Huang et al.   Cell Discovery

Pharmacological effectors of GRP78 chaperone in cancers

(2019) Christian Bailly et al.   BIOCHEMICAL PHARMACOLOGY

Dabrafenib and Trametinib in BRAF Mutant Metastatic Conjunctival Melanoma

(2019) Ernesto Rossi et al.   Frontiers in Oncology

Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

(2019) Xiaokang Li et al.   Acta Pharmaceutica Sinica B

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid

(2019) Isabel V. L. Wilkinson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma

(2019) Rossi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

(2019) Erik Tambuyzer et al.   NATURE REVIEWS DRUG DISCOVERY

NF1 mutations in conjunctival melanoma

(2018) S. L. Scholz et al.   BRITISH JOURNAL OF CANCER

Characterization of a conjunctival melanoma cell line CM-AS16, newly-established from a metastatic Han Chinese patient

(2018) Yongyun Li et al.   EXPERIMENTAL EYE RESEARCH

Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling

(2018) Kang-Hoon Kim et al.   Frontiers in Pharmacology

Roles and mechanisms of Kinesin-6 KIF20A in spindle organization during cell division

(2018) Wen-Da Wu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells

(2018) Yanting Chai et al.   MEDICAL SCIENCE MONITOR

Binimetinib for the treatment of NRAS-mutant melanoma

(2017) Paola Queirolo et al.   Expert Review of Anticancer Therapy

Advances in the management of conjunctival melanoma

(2017) Gargi K. Vora et al.   SURVEY OF OPHTHALMOLOGY

NRAS-mutant melanoma: current challenges and future prospect

(2017) Eva Muñoz-Couselo et al.   OncoTargets and Therapy

Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells

(2017) Yingchun Qu et al.   Oncology Letters

A case report of a patient with metastatic ocular melanoma who experienced a response to treatment with the BRAF inhibitor vemurafenib

(2016) A. Maleka et al.   BMC CANCER

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

(2016) Michaël Cerezo et al.   CANCER CELL

Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein

(2016) Udhayakumar Gopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence

(2016) Feifei Chen et al.   Nature Chemical Biology

Worldwide collaboration for orphan drug designation

(2016) Segundo Mariz et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy

(2016) Jinfeng Cao et al.   Oncotarget

JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification

(2015) W. Sun et al.   CANCER RESEARCH

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

(2014) B. Kharabi Masouleh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cucurbitacin B potently suppresses non-small-cell lung cancer growth: Identification of intracellular thiols as critical targets

(2013) Hina Kausar et al.   CANCER LETTERS

Conjunctival Melanomas Harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas

(2013) K. G. Griewank et al.   CLINICAL CANCER RESEARCH

Targeting FOXM1 in cancer

(2012) Marianna Halasi et al.   BIOCHEMICAL PHARMACOLOGY

From Plk1 to Plk5

(2011) Guillermo de Cárcer et al.   CELL CYCLE

Outcomes in 15 Patients with Conjunctival Melanoma Treated with Adjuvant Topical Mitomycin C: Complications and Recurrences

(2011) Lauren C. Ditta et al.   OPHTHALMOLOGY

Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

(2009) Kin Tak Chan et al.   CANCER LETTERS

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

(2008) Zheng Fu et al.   NATURE CELL BIOLOGY

Topical Interferon Alfa in the Treatment of Conjunctival Melanoma and Primary Acquired Melanosis Complex

(2007) Paul T. Finger et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY