Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis

Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity

(2020) Jiaxin Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway

(2020) Prasad Dandawate et al.   Scientific Reports

Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin

(2020) Xiaohui Xu et al.   Aging-US

Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma

(2020) Lei Wang et al.   TISSUE & CELL

Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

(2019) Pengfei Liu et al.   MOLECULES

miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy

(2019) Huan Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Lung cancer-derived extracellular vesicles induced myotube atrophy and adipocyte lipolysis via the extracellular IL-6-mediated STAT3 pathway

(2019) Wenjun Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Emerging trends in the novel drug delivery approaches for the treatment of lung cancer

(2019) Parvarish Sharma et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis

(2018) Ruinian Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a

(2018) Hong Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

LncRNA HOTAIR promotes cell migration and invasion by regulating MKL1 via inhibition miR206 expression in HeLa cells

(2018) Peng Zheng et al.   Cell Communication and Signaling

Long non-coding RNA XIST sponges miR-34a to promotes colon cancer progression via Wnt/β-catenin signaling pathway

(2018) Ningning Sun et al.   GENE

Plumbagin suppresses the human large cell lung cancer cell lines by inhibiting IL-6/STAT3 signaling in vitro

(2018) Tao Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IL-37 mediates the anti-tumor activity in non-small cell lung cancer through IL-6/STAT3 pathway

(2018) Yan-Ming Deng et al.   Journal of Applied Biomedicine

Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC)

(2018) Young Kwang Chae et al.   Scientific Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells

(2018) Yibin Lin et al.   GENE

MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis

(2017) Yan Yang et al.   Molecular Cancer

lncRNA XIST interacts with miR-140 to modulate lung cancer growth by targeting iASPP

(2017) Yongjun Tang et al.   ONCOLOGY REPORTS

IL-6 and TNF-α promote metastasis of lung cancer by inducing epithelial-mesenchymal transition

(2017) Guan-Sheng Shang et al.   Oncology Letters

Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling

(2017) Jingkai Zhou et al.   Oncotarget

Protective Effects of Cucurbitacin B on Acute Lung Injury Induced by Sepsis in Rats

(2017) Shu Hua et al.   MEDICAL SCIENCE MONITOR

Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression

(2016) Jing Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis

(2016) Xue Wang et al.   JOURNAL OF HEPATOLOGY

NANOG regulates epithelial-mesenchymal transition and chemoresistance through activation of the STAT3 pathway in epithelial ovarian cancer

(2016) Suqing Liu et al.   TUMOR BIOLOGY

Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

(2016) Guo-Qing Wu et al.   Oncotarget

Cell type-specific properties and environment shape tissue specificity of cancer genes

(2016) Martin H. Schaefer et al.   Scientific Reports

Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells

(2015) Huaxia Luo et al.   BIOCHEMISTRY

IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study

(2015) Jung-Ta Kao et al.   BMC GASTROENTEROLOGY

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B

(2015) Fardous F. El-Senduny et al.   TUMOR BIOLOGY

Evaluation of pretreatment serum interleukin-6 and tumour necrosis factor alpha as a potential biomarker for recurrence in patients with oral squamous cell carcinoma

(2015) I. Skrinjar et al.   Medicina Oral Patologia Oral y Cirugia Bucal

Cucurbitacin B Induces DNA Damage, G2/M Phase Arrest, and Apoptosis Mediated by Reactive Oxygen Species (ROS) in Leukemia K562 Cells

(2014) Jiajie Guo et al.   Anti-Cancer Agents in Medicinal Chemistry

Long Non-Coding RNA H19 Promotes Glioma Cell Invasion by Deriving miR-675

(2014) Yan Shi et al.   PLoS One

The Emergence of lncRNAs in Cancer Biology

(2011) J. R. Prensner et al.   Cancer Discovery

Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration

(2010) Kin Tak Chan et al.   CANCER LETTERS