Biomaterial-enabled therapeutic modulation of cGAS-STING signaling for enhancing antitumor immunity

Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy

(2022) Michael P. Vincent et al.   CANCER CELL

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

(2022) Zezhong Liu et al.   CELL RESEARCH

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

(2022) Kyle M. Garland et al.   CHEMICAL REVIEWS

Photothermal-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by synergizing innate and adaptive immunity

(2022) Kaiyuan Liu et al.   BIOMATERIALS

Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition

(2022) Justin T. Low et al.   CANCER CELL

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

(2022) Saskia F. Erttmann et al.   IMMUNITY

Systemic nano-delivery of low-dose STING agonist targeted to CD103+ dendritic cells for cancer immunotherapy

(2022) Aatman S. Doshi et al.   JOURNAL OF CONTROLLED RELEASE

Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy

(2022) Hao Tian et al.   Nano Today

STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity

(2022) Eric L. Dane et al.   NATURE MATERIALS

Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles

(2022) Xuefeng Li et al.   Nature Nanotechnology

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

(2022) Janos Szebeni et al.   Nature Nanotechnology

Turning cold tumors hot: from molecular mechanisms to clinical applications

(2022) Jiahui Zhang et al.   TRENDS IN IMMUNOLOGY

Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair

(2022) Joshua L. Justice et al.   TRENDS IN MICROBIOLOGY

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

(2022) Qiwei Wang et al.   Nature Communications

STING agonist cGAMP enhances anti-tumor activity of CAR-NK cells against pancreatic cancer

(2022) Yanyan Da et al.   OncoImmunology

Biodegradable MnO-Based Nanoparticles with Engineering Surface for Tumor Therapy: Simultaneous Fenton-Like Ion Delivery and Immune Activation

(2022) Zhaoli Sun et al.   ACS Nano

Herpesvirus‐Mimicking DNAzyme‐Loaded Nanoparticles as a Mitochondrial DNA Stress Inducer to Activate Innate Immunity for Tumor Therapy

(2022) Xiu Zhao et al.   ADVANCED MATERIALS

Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists

(2022) Samuele Stazzoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy

(2022) Han Zhang et al.   BIOMATERIALS

MnO2-melittin nanoparticles serve as an effective anti-tumor immunotherapy by enhancing systemic immune response

(2022) Shupei Tang et al.   BIOMATERIALS

cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers

(2022) Christy Hong et al.   NATURE

STING activation promotes robust immune response and NK cell–mediated tumor regression in glioblastoma models

(2022) Gilles Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting STING to promote antitumor immunity

(2022) Emily N. Chin et al.   TRENDS IN CELL BIOLOGY

Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy

(2022) Wen Song et al.   ACS Nano

Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy

(2022) Zhu Li et al.   ACS Nano

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

(2022) Camilla Hald Albertsen et al.   ADVANCED DRUG DELIVERY REVIEWS

Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Platinum(II) Triphenylamine Complexes for Cancer Immunotherapy

(2022) Yu‐Yi Ling et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

(2022) Shunsuke Kitajima et al.   CANCER CELL

ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

(2022) Joanna H. Maltbaek et al.   IMMUNITY

Lanthanide-Nucleotide Coordination Nanoparticles for STING Activation

(2022) Zichao Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

STING-induced regulatory B cells compromise NK function in cancer immunity

(2022) Sirui Li et al.   NATURE

DNAzyme‐Assisted Nano‐Herb Delivery System for Multiple Tumor Immune Activation

(2022) Shiyu Du et al.   Small

Nanodelivery of cGAS-STING activators for tumor immunotherapy

(2022) Jianfeng Guo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses

(2022) Xuan Wang et al.   Nature Communications

Tumor-targeted delivery of a STING agonist improvescancer immunotherapy

(2022) You-tong Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

(2021) Zhilin Hu et al.   MOLECULAR CELL

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

(2021) Monisankar Ghosh et al.   CANCER CELL

Understanding and treating the inflammatory adverse events of cancer immunotherapy

(2021) Michael Dougan et al.   CELL

5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING

(2021) Jingru Tian et al.   EMBO JOURNAL

Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade

(2021) Wei Si et al.   GUT

Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect

(2021) Chao Wang et al.   JOURNAL OF CONTROLLED RELEASE

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

(2021) Wen Zhou et al.   MOLECULAR CELL

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

(2021) Marco Tigano et al.   NATURE

Prolonged activation of innate immune pathways by a polyvalent STING agonist

(2021) Suxin Li et al.   Nature Biomedical Engineering

Protein-Based Nanomedicine for Therapeutic Benefits of Cancer

(2021) Qiuhong Zhang et al.   ACS Nano

Peptide-based supramolecular hydrogels for local drug delivery

(2021) Zhenghao Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Manganese salts function as potent adjuvants

(2021) Rui Zhang et al.   Cellular & Molecular Immunology

Translational Applications of Hydrogels

(2021) Santiago Correa et al.   CHEMICAL REVIEWS

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

(2021) Álvaro de Mingo Pulido et al.   IMMUNITY

STING enhances cell death through regulation of reactive oxygen species and DNA damage

(2021) Thomas J. Hayman et al.   Nature Communications

Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers

(2021) Ming Yi et al.   Journal of Hematology & Oncology

Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway

(2021) Feng Ji et al.   Journal of Hematology & Oncology

Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

(2021) Fansen Meng et al.   MOLECULAR CELL

Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour

(2021) Seung-hwan Jeong et al.   Nature Communications

MET amplification attenuates lung tumor response to immunotherapy by inhibiting STING

(2021) Yong Zhang et al.   Cancer Discovery

Rationally designed drug delivery systems for the local treatment of resected glioblastoma

(2021) Chiara Bastiancich et al.   ADVANCED DRUG DELIVERY REVIEWS

To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives

(2021) Da Shi et al.   ADVANCED DRUG DELIVERY REVIEWS

Coordinating the Mechanisms of Action of Ferroptosis and the Photothermal Effect for Cancer Theranostics

(2021) Fantian Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

(2021) Antonio Marzio et al.   CELL

Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas

(2021) Funda Meric-Bernstam et al.   CLINICAL CANCER RESEARCH

Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion

(2021) Yang Liu et al.   Nature Nanotechnology

ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

(2021) Yuanqin Yang et al.   Science Advances

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

(2020) Binbin Ding et al.   ADVANCED MATERIALS

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

(2020) Yi Zhou et al.   IMMUNITY

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype

(2020) Carminia M. Della Corte et al.   Journal of Thoracic Oncology

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine

(2020) Chunju Fang et al.   Cellular & Molecular Immunology

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

(2020) Eslam Mohamed et al.   IMMUNITY

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

(2020) Chun Zhou et al.   IMMUNITY

Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer

(2020) Vicky Makker et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NK cells mediate clearance of CD8+ T cell–resistant tumors in response to STING agonists

(2020) Christopher J. Nicolai et al.   Science Immunology

Old dogs, new trick: classic cancer therapies activate cGAS

(2020) Seoyun Yum et al.   CELL RESEARCH

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

(2020) Yuanyuan Zhang et al.   Cellular & Molecular Immunology

ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

(2020) Xu Feng et al.   EMBO JOURNAL

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

(2020) Xuewu Zhang et al.   IMMUNITY

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

(2020) Takahiro Yamazaki et al.   NATURE IMMUNOLOGY

cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy

(2020) Wenwen Li et al.   Science Translational Medicine

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

(2020) Yanpu He et al.   Science Advances

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

(2020) Feihu Wang et al.   Nature Biomedical Engineering

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

(2020) Chien-Hsiung Yu et al.   CELL

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

DNA Damage and Cancer Immunotherapy: A STING in the Tale

(2020) Timo Reisländer et al.   MOLECULAR CELL

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS

(2020) L. G. Webb et al.   PLoS Pathogens

Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

(2020) Jingjing Liang et al.   Science Advances

In situ activation of STING pathway with polymeric SN38 for cancer chemoimmunotherapy

(2020) Jiayu Zhao et al.   BIOMATERIALS

DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

(2020) Changzheng Lu et al.   CANCER CELL

STING agonist promotes CAR T cell trafficking and persistence in breast cancer

(2020) Nuo Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metastasis and immune evasion from extracellular cGAMP hydrolysis

(2020) Jun Li et al.   Cancer Discovery

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

(2019) Anne Margriet Heijink et al.   Nature Communications

Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy

(2019) Gilles Berger et al.   TRENDS IN MOLECULAR MEDICINE

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Immunotherapy in colorectal cancer: rationale, challenges and potential

(2019) Karuna Ganesh et al.   Nature Reviews Gastroenterology & Hepatology

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

(2019) James B. Wing et al.   IMMUNITY

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

(2019) Chuan-xia Zhang et al.   CELL DEATH AND DIFFERENTIATION

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

(2019) Katherine C. Barnett et al.   CELL

Advances in drug delivery for post-surgical cancer treatment

(2019) Lin-Lin Bu et al.   BIOMATERIALS

Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy

(2019) Min Luo et al.   JOURNAL OF CONTROLLED RELEASE

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

(2019) Constantia Pantelidou et al.   Cancer Discovery

Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist

(2019) Xiaohui Zhang et al.   ACS Infectious Diseases

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

(2019) Sabrina L. Ergun et al.   CELL

STING pathway agonism as a cancer therapeutic

(2019) Blake A. Flood et al.   IMMUNOLOGICAL REVIEWS

HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

(2019) Shiying Wu et al.   NATURE CELL BIOLOGY

Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

(2019) Christina A. Hartl et al.   Journal for ImmunoTherapy of Cancer

Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

(2019) Ravi B. Patel et al.   ADVANCED MATERIALS

NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2–3, randomised, controlled trial

(2019) Sylvie Bonvalot et al.   LANCET ONCOLOGY

Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles

(2019) Claire Vanpouille-Box et al.   NATURE REVIEWS DRUG DISCOVERY

cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity

(2019) Zining Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

(2019) Miyu Moriyama et al.   Nature Communications

Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

(2019) Yusuke Matsuno et al.   Nature Communications

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

(2019) Marion V. Guerin et al.   Nature Communications

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

(2019) Linda Schadt et al.   Cell Reports

Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity

(2019) Johannes C. Melms et al.   CANCER RESEARCH

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

(2019) Cameron S. Field et al.   Cell Metabolism

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

(2019) Han Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy

(2018) David G. Leach et al.   BIOMATERIALS

Cytosolic DNA Sensing in Organismal Tumor Control

(2018) Claire Vanpouille-Box et al.   CANCER CELL

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

DNA mismatch repair in cancer

(2018) Marina Baretti et al.   PHARMACOLOGY & THERAPEUTICS

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases

(2018) Chun Gwon Park et al.   Science Translational Medicine

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

(2018) Julie M. Diamond et al.   Cancer Immunology Research

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Evaluation of explant responses to STING ligands: personalized immunosurgical therapy for head and neck squamous cell carcinoma

(2018) Jason R. Baird et al.   CANCER RESEARCH

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

(2018) Yuzhu Hou et al.   IMMUNITY

Innate Sensing of DNA Virus Genomes

(2018) Zhe Ma et al.   Annual Review of Virology

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Polymer–drug conjugate therapeutics: advances, insights and prospects

(2018) Iriny Ekladious et al.   NATURE REVIEWS DRUG DISCOVERY

Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles

(2018) Shannon Grabosch et al.   ONCOGENE

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State

(2017) Adelle P. McFarland et al.   IMMUNITY

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

(2017) Meng Michelle Xu et al.   IMMUNITY

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

(2017) Jingwei Xue et al.   Nature Nanotechnology

Perioperative events influence cancer recurrence risk after surgery

(2017) Jonathan G. Hiller et al.   Nature Reviews Clinical Oncology

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

DNA Damage and Repair Biomarkers of Immunotherapy Response

(2017) Kent W. Mouw et al.   Cancer Discovery

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

(2017) Sebastian Aguirre et al.   Nature Microbiology

Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression

(2016) Laura C. Funk et al.   DEVELOPMENTAL CELL

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Classification and characterization of microsatellite instability across 18 cancer types

(2016) Ronald J Hause et al.   NATURE MEDICINE

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

(2016) Emily Curran et al.   Cell Reports

Human Disease Phenotypes Associated With Mutations in TREX1

(2015) Gillian I. Rice et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

(2015) Anna-Maria Herzner et al.   NATURE IMMUNOLOGY

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

(2015) Tina M. Sali et al.   PLoS Pathogens

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation

(2014) S. F. Bakhoum et al.   Cancer Discovery

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

(2014) D. Chandra et al.   Cancer Immunology Research

Anticancer Flavonoids Are Mouse-Selective STING Agonists

(2013) Sujeong Kim et al.   ACS Chemical Biology

Species-specific detection of the antiviral small-molecule compound CMA by STING

(2013) Taner Cavlar et al.   EMBO JOURNAL

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non–Small-Cell Lung Cancer

(2011) Primo N. Lara et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology