Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

(2020) Chuanhui Han et al.   NATURE IMMUNOLOGY

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(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3

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Ibrutinib and Venetoclax for First-Line Treatment of CLL

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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

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Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

(2019) Maria Esperanza Rodriguez-Ruiz et al.   OncoImmunology

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment

(2019) Maria Esperanza Rodriguez-Ruiz et al.   NATURE IMMUNOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

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(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

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(2018) Claire McQuin et al.   PLOS BIOLOGY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

The hallmarks of successful anticancer immunotherapy

(2018) Lorenzo Galluzzi et al.   Science Translational Medicine

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

(2018) Silvia C. Formenti et al.   NATURE MEDICINE

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

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Implications of mitochondrial network organization in mitochondrial stress signalling in NARP cybrid and Rho0 cells

(2017) Jarosław Walczak et al.   Scientific Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming

(2016) M. E. Rodriguez-Ruiz et al.   CANCER RESEARCH

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

(2016) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

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(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

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(2015) Arthur Liberzon et al.   Cell Systems

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Cisplatin Resistance Associated with PARP Hyperactivation

(2013) J. Michels et al.   CANCER RESEARCH

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

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(2012) Ethan Cerami et al.   Cancer Discovery

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p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

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(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

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Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer

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