Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor

(2022) László Dézsi et al.   GeroScience

mRNA COVID-19 vaccine is well tolerated in patients with cutaneous and systemic mastocytosis with mast cell activation symptoms and anaphylaxis

(2021) Tiago Azenha Rama et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes

(2021) Megen C. Wittling et al.   Frontiers in Immunology

Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases

(2021) Aristo Vojdani et al.   Frontiers in Immunology

mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach

(2021) Aleena Banerji et al.   Journal of Allergy and Clinical Immunology-In Practice

Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines

(2021) S. Moein Moghimi   MOLECULAR THERAPY

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

(2021) Kimberly G. Blumenthal et al.   NEW ENGLAND JOURNAL OF MEDICINE

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

(2021) Noa Dagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID‐19 vaccine

(2021) Priya Sellaturay et al.   CLINICAL AND EXPERIMENTAL ALLERGY

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases

(2021) Devon E. McMahon et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Anaphylaxis to the first dose of mRNA SARS‐CoV‐2 vaccines: Don't give up on the second dose!

(2021) Matthew S. Krantz et al.   ALLERGY

IgE‐mediated allergy to polyethylene glycol (PEG) as a cause of anaphylaxis to mRNA COVID‐19 vaccines

(2021) John M Kelso   CLINICAL AND EXPERIMENTAL ALLERGY

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model

(2021) Can Li et al.   CLINICAL INFECTIOUS DISEASES

COVID-19 Vaccines in Children with Cow’s Milk and Food Allergies

(2021) Lucia Liotti et al.   Nutrients

Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights

(2021) Gurudeeban Selvaraj et al.   Interdisciplinary Sciences-Computational Life Sciences

Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose

(2021) Matthew S. Krantz et al.   JAMA Internal Medicine

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

(2021) Youssif M. Ali et al.   Frontiers in Immunology

Safety of COVID-19 vaccination in patients with mastocytosis and monoclonal mast cell activation syndrome

(2021) Rayan Kaakati et al.   Journal of Allergy and Clinical Immunology-In Practice

Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System

(2021) Christopher Michael Warren et al.   JAMA Network Open

The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory

(2021) Sonia Ndeupen et al.   iScience

Using Baseline and Peak Serum Tryptase Levels to Diagnose Anaphylaxis: a Review

(2020) Evangelia Passia et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Immunization stress-related response – Redefining immunization anxiety-related reaction as an adverse event following immunization

(2020) Michael S. Gold et al.   VACCINE

Improved Nylon 6,6 Nanofiber Membrane in A Tilted Panel Filtration System for Fouling Control in Microalgae Harvesting

(2020) Normi Izati Mat Nawi et al.   Polymers

Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display

(2020) Tomohiro Shirayanagi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inflammasomes as Targets for Adjuvants

(2020) Konstantin Ivanov et al.   Pathogens

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

(2020) Gergely Tibor Kozma et al.   ADVANCED DRUG DELIVERY REVIEWS

Clinical utility of next generation sequencing based HLA typing for disease association and pharmacogenetic testing

(2020) Tracie Profaizer et al.   HUMAN IMMUNOLOGY

Changing the paradigm of IFN‐γ at the interface between innate and adaptive immunity: Macrophage‐derived IFN‐γ

(2020) Soraya Mezouar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HLA genotypes and cold medicine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis

(2020) Wimonchat Tangamornsuksan et al.   Scientific Reports

Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy

(2020) Kristi Krebs et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

(2020) Jia Yu et al.   BLOOD

PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production

(2020) Takuya Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

(2020) Si Zhang et al.   Journal of Hematology & Oncology

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

(2020) Evan J. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

(2020) Mary Hongying Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome-Mediated Immunogenicity of Clinical and Experimental Vaccine Adjuvants

(2020) Sören Reinke et al.   Vaccines

Interleukin‐6: A novel biomarker for monoclonal antibody and chemotherapy‐associated hypersensitivity confirms a cytokine release syndrome phenotype‐endotype association

(2020) Baruch D. Jakubovic et al.   ALLERGY

Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?

(2020) Lene H. Garvey et al.   BRITISH JOURNAL OF ANAESTHESIA

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Maintaining Safety with SARS-CoV-2 Vaccines

(2020) Mariana C. Castells et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

(2020) Lien Van Hoecke et al.   Molecular Therapy-Nucleic Acids

The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Moderna COVID-19 Vaccine — United States, December 2020

(2020) Sara E. Oliver et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department

(2020) Annalisa Schirinzi et al.   JOURNAL OF INFECTION

Anti-PEG IgE in anaphylaxis associated with polyethylene glycol

(2020) Zhao-Hua Zhou et al.   Journal of Allergy and Clinical Immunology-In Practice

Delivery of mRNA to platelets using lipid nanoparticles

(2019) S. Novakowski et al.   Scientific Reports

Nanoparticle physicochemical properties determine the activation of intracellular complement

(2019) Anna N. Ilinskaya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

(2019) Kevin E. Lindsay et al.   Nature Biomedical Engineering

Pseudo-Anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

(2019) Gergely Tibor Kozma et al.   ACS Nano

Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

(2019) Melissa P. Lokugamage et al.   ADVANCED MATERIALS

Role of Oxidative Stress in Hypersensitivity Reactions to Sulfonamides

(2019) Abdelbaset A. Elzagallaai et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing

(2019) Ken Nakatani et al.   Scientific Reports

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

(2018) Jasmine Viger-Gravel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro

(2018) Barry Neun et al.   MOLECULES

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roadmap and strategy for overcoming infusion reactions to nanomedicines

(2018) Janos Szebeni et al.   Nature Nanotechnology

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized

(2018) Cosby A. Stone et al.   Journal of Allergy and Clinical Immunology-In Practice

Diagnosis and management of anaphylaxis in precision medicine

(2017) Mariana Castells   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey

(2017) Maja Sedic et al.   VETERINARY PATHOLOGY

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

(2016) Bing-Mae Chen et al.   ANALYTICAL CHEMISTRY

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans

(2016) Yang Li et al.   CELL

Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation

(2016) Koa Hosoki et al.   Current Opinion in Allergy and Clinical Immunology

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

(2016) Stanley T Crooke et al.   MOLECULAR THERAPY

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

(2016) Jonathan J Lyons et al.   NATURE GENETICS

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi

(2016) Yang Li et al.   NATURE MEDICINE

Adverse events following pandemic influenza A (H1N1) 2009 monovalent and seasonal influenza vaccinations during the 2009–2010 season in the active component U.S. military and civilians aged 17–44years reported to the Vaccine Adverse Event Reporting System

(2016) Barbara H. Bardenheier et al.   VACCINE

Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies

(2016) David Sloane et al.   Journal of Allergy and Clinical Immunology-In Practice

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

(2015) Marina A. Dobrovolskaia   JOURNAL OF CONTROLLED RELEASE

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Induction of oxidative stress by Taxol® vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNA

(2015) Anna N. Ilinskaya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Complement-Coagulation Cross-Talk: A Potential Mediator of the Physiological Activation of Complement by Low pH

(2015) Hany Ibrahim Kenawy et al.   Frontiers in Immunology

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies

(2014) C. A. Fernandez et al.   BLOOD

Complement activation-related pseudoallergy: A stress reaction in blood triggered by nanomedicines and biologicals

(2014) Janos Szebeni   MOLECULAR IMMUNOLOGY

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

(2013) Marina A. Dobrovolskaia et al.   JOURNAL OF CONTROLLED RELEASE

Immediate hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines: Reports to VAERS

(2013) Neal A. Halsey et al.   VACCINE

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates

(2012) Merry R. Sherman et al.   BIOCONJUGATE CHEMISTRY

2012 Update

(2012) F. Estelle R. Simons et al.   Current Opinion in Allergy and Clinical Immunology

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Algorithm to assess causality after individual adverse events following immunizations

(2012) Neal A. Halsey et al.   VACCINE

Analysis of anaphylaxis cases after vaccination: 10-year review from the national vaccine injury compensation program

(2011) Rosemary Johann-Liang et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

HLA alleles and drug hypersensitivity reactions

(2011) T. Profaizer et al.   International Journal of Immunogenetics

Interactions of Human Complement with Virus Particles Containing the Nipah Virus Glycoproteins

(2011) J. B. Johnson et al.   JOURNAL OF VIROLOGY

Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro

(2011) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Implications of oxidative stress mechanisms in toxicity of nanoparticles (review)

(2010) Teodora Mocan et al.   ACTA PHYSIOLOGICA HUNGARICA

Variable Antibody-dependent Activation of Complement by Functionalized Phospholipid Nanoparticle Surfaces

(2010) Christine T. N. Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a

(2009) Hydar Ali   IMMUNOLOGY LETTERS

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY