Article
Cell Biology
Josep Monserrat, Cristina Morales Torres, Louise Richardson, Thomas Stuart Wilson, Harshil Patel, Marie-Charlotte Domart, Stuart Horswell, Ok-Ryul Song, Ming Jiang, Margaret Crawford, Minh Bui, Yamini Dalal, Paola Scaffidi
Summary: The inactivation of MSL enhances chromosomal instability, leading to the suppression of tumour maintenance. Targeting MSL may increase chromosomal instability in cancer cells without severe adverse effects in normal tissues.
NATURE CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Feng-ling Ning, Jie Tao, Dan-dan Li, Lu-lu Tian, Meng-ling Wang, Svetlana Reilly, Cheng Liu, Hui Cai, Hong Xin, Xue-mei Zhang
Summary: Vascular calcification is a disease characterized by pathological depositions of calcium and phosphate in the arteries and veins, which can be alleviated by activating large-conductance calcium-activated potassium (BK) channels. The role of BK channels in decreasing calcification is achieved by reducing calcium content and alkaline phosphatase activity.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Guanlan Fan, Fan Wang, Yurou Chen, Qian Zheng, Jie Xiong, Qiongying Lv, Kejia Wu, Jiaqiang Xiong, Lei Wei, Dongqing Li, Jiachen Zhang, Wei Zhang, Feng Li
Summary: In this study, OTUD1 is identified as an Akt-associated protein and is downregulated upon Akt activation. Ectopic OTUD1 inhibits Akt phosphorylation, and a short peptide (OUN-36) located in the OTUD1 N-terminal intrinsically disordered region strongly binds to the Akt PH domain. OUN-36-based therapy efficiently abrogates Akt feedback reactivation and sensitizes cancer cells to chemotherapy and immunotherapy.
Article
Biochemistry & Molecular Biology
Ramendu Parial, Hui Li, Jia Li, Stephen Archacki, Zhongcheng Yang, Isabel Z. Wang, Qiuyun Chen, Chengqi Xu, Qing K. Wang
Summary: m6A RNA methylation plays a crucial role in vascular development by regulating the AKT signaling pathway.
Article
Oncology
Jing Xu, Yi Gao, Xiaotian Luan, Ke Li, Jing Wang, Yilin Dai, Mingyi Kang, Chong Lu, Minhua Zhang, Chris X. Lu, Yu Kang, Congjian Xu
Summary: The combination of AKT inhibitor and PARP inhibitor shows anti-tumor effects in recurrent ovarian cancer patients. AKT inhibition enhances the sensitivity of tumor cells to PARP inhibition and reduces the activity of PARP enzymes or the expression level of PARP1 protein.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Huajian Yu, Lei Zhou, Jane H. C. Loong, Ka-Hei Lam, Tin-Lok Wong, Kai-Yu Ng, Man Tong, Victor W. S. Ma, Yanyan Wang, Xiang Zhang, Terence K. Lee, Jing-Ping Yun, Jun Yu, Stephanie Ma
Summary: This study aims to identify molecular factors specific to CD133(+) HCC and discover their role in cancer stemness. Transcriptome profiling revealed the overexpression of SERPINA12 in HCC CD133(+) cells, which is associated with aggressive clinical features and stemness signatures. Functional characterization showed that SERPINA12 promotes self-renewal, therapy resistance, and metastasis by activating the AKT/beta-catenin signaling cascade through binding to GRP78.
Article
Oncology
Teng He, Zhixing Hao, Mingjie Lin, Zhongwei Xin, Yongyuan Chen, Wei Ouyang, Qi Yang, Xiaoke Chen, Hui Zhou, Wanying Zhang, Pin Wu, Feng Xu
Summary: This study demonstrates that an oncolytic adenovirus carrying mIL-15 can induce an effective antitumor immune response and inhibit tumor growth in a mouse model of cancer. The virus promotes activation and infiltration of immune cells, as well as vascular normalization and tertiary lymphoid structure formation in the tumor microenvironment. These changes are dependent on the activation of the STING-TBK1-IRF3 pathway in dendritic cells.
Article
Ophthalmology
Hideaki Someya, Masataka Ito, Yoshiaki Nishio, Tomohito Sato, Kozo Harimoto, Masaru Takeuchi
Summary: Diabetic retinopathy, a major cause of blindness in developed countries, can be caused by elevated levels of osteopontin (OPN), leading to vascular hyperpermeability and retinal edema. This study found that anti-OPN treatment can mitigate vascular hyperpermeability and restore the expression of key proteins in the retina.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Medicine, Research & Experimental
Rattanaporn Jaidee, Veerapol Kukongviriyapan, Laddawan Senggunprai, Auemduan Prawan, Apinya Jusakul, Phatthamon Laphanuwat, Sarinya Kongpetch
Summary: Knockdown of FGFR2 suppressed cell growth and colony formation in CCA cells through G2/M cell cycle arrest and downregulation of STAT3, cyclin A, and cyclin B1. Silencing FGFR2 enhanced the suppressive effect of gemcitabine on cell migration and invasion.
Article
Immunology
Yunfei Dong, Yuanyuan Wang, Xuechen Yin, Hongqiao Zhu, Lingjie Liu, Miaomiao Zhang, Jiannan Chen, Aying Wang, Tinghui Huang, Jianhua Hu, Junqing Liang, Zhigang Guo, Lingfeng He
Summary: Chimeric antigen receptor T-cell immunotherapy (CAR-T-cell immunotherapy) is effective in haematological tumours but faces challenges in solid tumours, such as poor T-cell infiltration and functional persistence. Flap structure-specific endonuclease 1 (FEN1), highly expressed in cancer cells, is involved in DNA replication and repair. Inhibiting FEN1 has been shown to be an effective strategy for cancer treatment. This study suggests that combining FEN1 inhibitors with CAR-T-cell immunotherapy can enhance the killing effect on solid tumours by promoting T-cell infiltration and improving anti-tumour immunity.
Article
Pharmacology & Pharmacy
Ganesh Pai Bellare, Birija Sankar Patro
Summary: This study proposes the usage of resveratrol as a chemosensitizer in combination with talazoparib for targeting HR proficient breast cancers. Resveratrol effectively enhances talazoparib-induced cell death in breast cancer cells and shows minimal cytotoxicity in normal cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sibasish Mohanty, Pallavi Mohapatra, Omprakash Shriwas, Shamima Azma Ansari, Manashi Priyadarshini, Swatismita Priyadarsini, Rachna Rath, Mahesh Sultania, Saroj Kumar Das Majumdar, Rajeeb K. Swain, Rupesh Dash
Summary: This study identified MINK1 as a key mediator of 5FU resistance in OSCC by modulating the p53 signaling pathway. The inhibitor of MINK1 kinase activity, Lestaurtinib, can restore sensitivity to 5FU and reduce tumor burden, suggesting a potential new treatment strategy for advanced OSCC.
Article
Cell Biology
Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang
Summary: Baicalin is a natural active ingredient that can cross the blood-brain barrier and has neuroprotective effects on multiple central nervous system diseases. This study investigated the mechanism of action of Baicalin in treating spinal cord injury and found that it can inhibit blood-spinal cord barrier permeability and reduce neuronal apoptosis by activating the PI3K/Akt signaling pathway.
NEURAL REGENERATION RESEARCH
(2022)
Article
Oncology
Weiwei Yan, Qiuying Han, Lin Gong, Xiaoyan Zhan, Wanjin Li, Zenglin Guo, Jiangman Zhao, Tingting Li, Zhaofang Bai, Jin Wu, Yan Huang, Luye Lv, Haixin Zhao, Hong Cai, Shaoyi Huang, Xinwei Diao, Yuan Chen, Weili Gong, Qing Xia, Jianghong Man, Liang Chen, Guanghai Dai, Tao Zhou
Summary: This study reveals that Methyl-CpG binding domain protein 3 (MBD3) is significantly overexpressed in hepatocellular carcinoma (HCC) and is associated with advanced tumor stage and poor prognosis. MBD3 promotes the growth, angiogenesis, and metastasis of HCC cells by inhibiting the tumor suppressor tissue factor pathway inhibitor 2 (TFPI2). Mechanistically, MBD3 can inhibit the transcription of TFPI2 via the Nucleosome Remodeling and Deacetylase (NuRD) complex-mediated deacetylation, leading to the reactivation of matrix metalloproteinases (MMPs) and PI3K/AKT signaling pathway, thus contributing to the progression and metastasis of HCC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Zhou Zhongyin, Wang Wei, Xiong Juan, Fan Guohua
Summary: This study found that epigallocatechin gallate (EG), a natural polyphenol extracted from green tea, could improve PM2.5-induced lung fibrosis by reducing oxidative damage and epithelial-mesenchymal transition (EMT) through the AKT/mTOR pathway. Intragastric administration of EG prevented lung injury, inflammation, and oxidative stress in mice exposed to PM2.5. In vitro experiments showed that EG treatment enhanced cell viability in PM2.5-treated lung epithelial cells. Overexpression of AKT offset the inhibitory effects of EG on EMT and oxidative stress. EG may be a potential candidate for the treatment of PM2.5-induced lung fibrosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell & Tissue Engineering
Jung Mo Kim, Ki-Sung Hong, Won Kyung Song, Daekyeong Bae, In-Kyu Hwang, Jong Soo Kim, Hyung-Min Chung
STEM CELLS TRANSLATIONAL MEDICINE
(2016)
Article
Cell Biology
Urs H. Langen, Mara E. Pitulescu, Jung Mo Kim, Rocio Enriquez-Gasca, Kishor K. Sivaraj, Anjali P. Kusumbe, Amit Singh, Jacopo Di Russo, M. Gabriele Bixel, Bin Zhou, Lydia Sorokin, Juan M. Vaquerizas, Ralf H. Adams
NATURE CELL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Hyun-Woo Jeong, Benjamin Hernandez-Rodriguez, JungMo Kim, Kee-Pyo Kim, Rocio Enriquez-Gasca, Juyong Yoon, Susanne Adams, Hans R. Schoeler, Juan M. Vaquerizas, Ralf H. Adams
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Yoo Hyung Kim, Jeongwoon Choi, Myung Jin Yang, Seon Pyo Hong, Choong-Kun Lee, Yoshiaki Kubota, Dae-Sik Lim, Gou Young Koh
NATURE COMMUNICATIONS
(2019)
Review
Biochemical Research Methods
JungMo Kim, Maria Gabriele Bixel
Article
Multidisciplinary Sciences
Sung Yong Choi, Hosung Bae, Sun-Hye Jeong, Intae Park, Hyunsoo Cho, Seon Pyo Hong, Da-Hye Lee, Choong-kun Lee, Jin-Sung Park, Sang Heon Suh, Jeongwoon Choi, Myung Jin Yang, Jeon Yeob Jang, Lucas Onder, Jeong Hwan Moon, Han-Sin Jeong, Ralf H. Adams, Jin-Man Kim, Burkhard Ludewig, Joo-Hye Song, Dae-Sik Lim, Gou Young Koh
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Bong Ihn Koh, Hyuek Jong Lee, Pil Ae Kwak, Myung Jin Yang, Ju-Hee Kim, Hyung-Seok Kim, Gou Young Koh, Injune Kim
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H. Adams, Kari Alitalo, Daesik Lim, Gou Young Koh
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Jung Hyun Bae, Myung Jin Yang, Seung-Hwan Jeong, JungMo Kim, Seon Pyo Hong, Jin Woo Kim, Yoo Hyung Kim, Gou Young Koh
Summary: In this study, the researchers discovered that Merlin, encoded by the neurofibromatosis type 2 (NF2) gene, suppresses VEGFR2 internalization and controls the induction of tip endothelial cells (EC). Depletion of Nf2 in endothelial cells enhances VEGFR2 internalization and leads to excessive filopodia formation in tip EC induction. Merlin binds to the VEGFR2-VE-cadherin complex and reduces downstream signaling, thus affecting the induction of tip ECs.
Article
Multidisciplinary Sciences
Hyuek Jong Lee, Jueun Lee, Myung Jin Yang, Young-Chan Kim, Seon Pyo Hong, Jung Mo Kim, Geum-Sook Hwang, Gou Young Koh
Summary: This study reveals that cellular crosstalk between endothelial cells and brown adipocytes plays a crucial role in lipid accumulation in brown adipose tissue (BAT). The stem cell factor (SCF) derived from endothelial cells promotes lipid accumulation by activating the c-Kit pathway. Understanding this mechanism is important for addressing metabolic diseases.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Ji Hoon Ahn, JungMo Kim, Seon Pyo Hong, Sung Yong Choi, Myung Jin Yang, Young Seok Ju, Young Tae Kim, Ho Min Kim, Md Tazikur Rahman, Man Ki Chung, Sang Duk Hong, Hosung Bae, Chang-Seop Lee, Gou Young Koh
Summary: Research shows that in the early stages of COVID-19, the virus replicates massively in multiciliated cells of the nasal epithelium, and infected ciliated cells are rapidly replaced by differentiating precursor cells.
JOURNAL OF CLINICAL INVESTIGATION
(2021)