Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Platinum(II) Triphenylamine Complexes for Cancer Immunotherapy

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

(2022) Kyle M. Garland et al.   CHEMICAL REVIEWS

The cGAS/STING Pathway: A Novel Target for Cancer Therapy

(2022) Yu Gan et al.   Frontiers in Immunology

Enhancing Circulation and Tumor Accumulation of Carboplatin via an Erythrocyte‐Anchored Prodrug Strategy

(2022) Houzong Yao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy

(2022) Zhi‐Yuan Li et al.   Chemistry-An Asian Journal

Activation of STING by targeting a pocket in the transmembrane domain

(2022) Defen Lu et al.   NATURE

STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments

(2022) Danilo Guerini   Cells

Quality control of the mitochondrion

(2021) Matthew Yoke Wui Ng et al.   DEVELOPMENTAL CELL

Prolonged activation of innate immune pathways by a polyvalent STING agonist

(2021) Suxin Li et al.   Nature Biomedical Engineering

A Continuous Add‐On Probe Reveals the Nonlinear Enlargement of Mitochondria in Light‐Activated Oncosis

(2021) Kang‐Nan Wang et al.   Advanced Science

STING nuclear partners contribute to innate immune signaling responses

(2021) Charles R. Dixon et al.   iScience

19 F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions

(2021) Siming Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ferroptosis‐Enhanced Cancer Immunity by a Ferrocene‐Appended Iridium(III) Diphosphine Complex

(2021) Wen‐Jin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

(2021) Xuxian Su et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chromatin mobility and relocation in DNA repair

(2021) Noa Lamm et al.   TRENDS IN CELL BIOLOGY

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

Content Detection of G‐Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structures

(2020) Liu-Yi Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism

(2020) Zhiqin Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiple‐Color Platinum Complex with Super‐Large Stokes Shift for Super‐Resolution Imaging of Autolysosome Escape

(2020) Liu-Yi Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors

(2020) Qian Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PlatinER: a Highly Potent Anticancer Platinum(II) Complex that induces Endoplasmic Reticulum Stress‐driven Immunogenic Cell Death

(2020) Max Jing Rui Tham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

(2020) Xuewu Zhang et al.   IMMUNITY

BODI-Pt, a Green-Light-Activatable and Carboplatin-Based Platinum(IV) Anticancer Prodrug with Enhanced Activation and Cytotoxicity

(2020) Houzong Yao et al.   INORGANIC CHEMISTRY

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

(2020) Suxing Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

(2020) Chien-Hsiung Yu et al.   CELL

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

cGAS-STING pathway in cancer biotherapy

(2020) Yang Wang et al.   Molecular Cancer

An ER‐Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non‐Small‐Cell Lung Cancer

(2020) Lili Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

(2019) Baoyu Zhao et al.   NATURE

The Clinical Development of Carboplatin – A Personal Perspective

(2019) Hilary Calvert   INORGANICA CHIMICA ACTA

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Phorbiplatin, a Highly Potent Pt(IV) Antitumor Prodrug That Can Be Controllably Activated by Red Light

(2019) Zhigang Wang et al.   Chem

The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

(2018) Wenting Liu et al.   Nature Communications

Metal Drugs and the Anticancer Immune Response

(2018) Bernhard Englinger et al.   CHEMICAL REVIEWS

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

The Cellular Mitochondrial Genome Landscape in Disease

(2018) Anne Hahn et al.   TRENDS IN CELL BIOLOGY

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Crystal structure of the DNA sequence d(CGTGAATTCACG)2 with DAPI

(2017) Hristina I. Sbirkova-Dimitrova et al.   Acta Crystallographica Section F-Structural Biology Communications

A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance

(2016) Zhigang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Visible-Light-Induced Annihilation of Tumor Cells with Platinum-Porphyrin Conjugates

(2014) Anu Naik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted theranostic prodrugs based on an aggregation-induced emission (AIE) luminogen for real-time dual-drug tracking

(2014) Youyong Yuan et al.   CHEMICAL COMMUNICATIONS

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A New Entry to Asymmetric Platinum(IV) Complexes via Oxidative Chlorination

(2014) Mauro Ravera et al.   INORGANIC CHEMISTRY

Chloroquine Promotes IL-17 Production by CD4+T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells

(2014) André Said et al.   JOURNAL OF IMMUNOLOGY

Targeted Theranostic Platinum(IV) Prodrug with a Built-In Aggregation-Induced Emission Light-Up Apoptosis Sensor for Noninvasive Early Evaluation of Its Therapeutic Responses in Situ

(2014) Youyong Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)

(2012) Christopher W. Davies et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy

(2012) R. Ramakrishnan et al.   CANCER RESEARCH

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

(2011) W. Joost Lesterhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Finding a fitting shoe for Cinderella

(2010) Simon Miller et al.   Autophagy

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device

(2008) Shanta Dhar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH