Ferroptosis: A flexible constellation of related biochemical mechanisms
Published 2023 View Full Article
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Title
Ferroptosis: A flexible constellation of related biochemical mechanisms
Authors
Keywords
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Journal
MOLECULAR CELL
Volume 83, Issue 7, Pages 1030-1042
Publisher
Elsevier BV
Online
2023-03-27
DOI
10.1016/j.molcel.2023.03.005
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Note: Only part of the references are listed.- Identification of essential sites of lipid peroxidation in ferroptosis
- (2023) A. Nikolai von Krusenstiern et al. Nature Chemical Biology
- NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
- (2023) Annadurai Anandhan et al. Science Advances
- Human hematopoietic stem cell vulnerability to ferroptosis
- (2023) Jiawei Zhao et al. CELL
- TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids
- (2023) Alex Reed et al. Nature Chemical Biology
- PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
- (2022) Hai-Liang Zhang et al. NATURE CELL BIOLOGY
- Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity
- (2022) Amy Tarangelo et al. Life Science Alliance
- Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining
- (2022) Jenny Jin et al. ACS Chemical Biology
- Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability
- (2022) Zhipeng Li et al. Nature Chemical Biology
- HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation
- (2022) Shangting Han et al. Oxidative Medicine and Cellular Longevity
- Ferroptosis regulation by the NGLY1/NFE2L1 pathway
- (2022) Giovanni C. Forcina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
- (2022) Brent R. Stockwell CELL
- Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death
- (2022) Luke A. Farmer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A non-canonical vitamin K cycle is a potent ferroptosis suppressor
- (2022) Eikan Mishima et al. NATURE
- The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis
- (2022) Kha The Nguyen et al. NATURE CELL BIOLOGY
- Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
- (2022) Caterina Bartolacci et al. Nature Communications
- Sublethal cytochrome c release generates drug-tolerant persister cells
- (2022) Halime Kalkavan et al. CELL
- Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
- (2022) Fan Yang et al. Cell Metabolism
- FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations
- (2022) Nan Zhou et al. NUCLEIC ACIDS RESEARCH
- Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity
- (2022) Marcos A. Perez et al. PLoS Genetics
- Differences in cell death in methionine versus cysteine depletion
- (2021) Katherine F. Wallis et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- A compendium of kinetic modulatory profiles identifies ferroptosis regulators
- (2021) Megan Conlon et al. Nature Chemical Biology
- Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal
- (2021) Wan-Yang Sun et al. Nature Chemical Biology
- mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
- (2021) Yilei Zhang et al. Nature Communications
- Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
- (2021) Alexander Beatty et al. Nature Communications
- Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects
- (2021) Emeline Dierge et al. Cell Metabolism
- iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
- (2021) Delin Chen et al. Nature Communications
- Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway
- (2021) Sufang Shui et al. Redox Biology
- Characterization of a patient-derived variant of GPX4 for precision therapy
- (2021) Hengrui Liu et al. Nature Chemical Biology
- A roadmap to creating ferroptosis-based medicines
- (2021) Kamyar Hadian et al. Nature Chemical Biology
- Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
- (2020) Yilong Zou et al. Nature Chemical Biology
- Lipid peroxidation and ferroptosis: The role of GSH and GPx4
- (2020) Fulvio Ursini et al. FREE RADICAL BIOLOGY AND MEDICINE
- Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
- (2020) John K. Eaton et al. Nature Chemical Biology
- A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway
- (2020) Jonathan M. Ghergurovich et al. Nature Chemical Biology
- Cysteine depletion induces pancreatic tumor ferroptosis in mice
- (2020) Michael A. Badgley et al. SCIENCE
- Transferrin Receptor Is a Specific Ferroptosis Marker
- (2020) Huizhong Feng et al. Cell Reports
- Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells
- (2020) Marcos A. Perez et al. DEVELOPMENTAL CELL
- Roles of polyunsaturated fatty acids, from mediators to membranes
- (2020) Takeshi Harayama et al. JOURNAL OF LIPID RESEARCH
- Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
- (2020) Mariluz Soula et al. Nature Chemical Biology
- p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen
- (2020) Liz J. Valente et al. JOURNAL OF CELL BIOLOGY
- Lymph protects metastasizing melanoma cells from ferroptosis
- (2020) Jessalyn M. Ubellacker et al. NATURE
- Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
- (2020) Yilong Zou et al. NATURE
- Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture
- (2020) Michelle Riegman et al. NATURE CELL BIOLOGY
- Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53
- (2020) Julia I-Ju Leu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PLA2G6 guards placental trophoblasts against ferroptotic injury
- (2020) Ofer Beharier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis
- (2020) Yun Pyo Kang et al. Cell Metabolism
- Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1
- (2020) Bo Yan et al. MOLECULAR CELL
- Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis
- (2020) Junmei Yi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
- (2019) Javier Garcia-Bermudez et al. NATURE
- Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
- (2019) Ishraq Alim et al. CELL
- The Coming Decade of Cell Death Research: Five Riddles
- (2019) Douglas R. Green CELL
- ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
- (2019) Bo Chu et al. NATURE CELL BIOLOGY
- Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53
- (2019) Julia I-Ju Leu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
- (2019) Jiao Wu et al. NATURE
- A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
- (2019) Yilong Zou et al. Nature Communications
- The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma
- (2019) Wen-Hsuan Yang et al. Cell Reports
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- The chemical basis of ferroptosis
- (2019) Marcus Conrad et al. Nature Chemical Biology
- GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
- (2019) Vanessa A. N. Kraft et al. ACS Central Science
- Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
- (2018) Michael M. Gaschler et al. ACS Chemical Biology
- Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
- (2018) Jennifer Tsoi et al. CANCER CELL
- Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
- (2018) Irina Ingold et al. CELL
- Regulation of lipid peroxidation and ferroptosis in diverse species
- (2018) Marcus Conrad et al. GENES & DEVELOPMENT
- p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
- (2018) Amy Tarangelo et al. Cell Reports
- Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
- (2018) Ron Shah et al. ACS Central Science
- Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death
- (2018) Marta Bogacz et al. eLife
- Role of Mitochondria in Ferroptosis
- (2018) Minghui Gao et al. MOLECULAR CELL
- Heat stress induces ferroptosis-like cell death in plants
- (2017) Ayelén Mariana Distéfano et al. JOURNAL OF CELL BIOLOGY
- Rate of Lipid Peroxyl Radical Production during Cellular Homeostasis Unraveled via Fluorescence Imaging
- (2017) Lana E. Greene et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
- (2017) Samantha W. Alvarez et al. NATURE
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
- (2017) Yangchun Xie et al. Cell Reports
- On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death
- (2017) Omkar Zilka et al. ACS Central Science
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Ferroptosis is an autophagic cell death process
- (2016) Minghui Gao et al. CELL RESEARCH
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
- (2016) Kenichi Shimada et al. Nature Chemical Biology
- Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
- (2016) Wan Seok Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- (2015) Scott J. Dixon et al. ACS Chemical Biology
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective
- (2014) Keith U. Ingold et al. CHEMICAL REVIEWS
- Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
- (2014) Rachid Skouta et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- The role of iron and reactive oxygen species in cell death
- (2013) Scott J Dixon et al. Nature Chemical Biology
- Data, information, knowledge and principle: back to metabolism in KEGG
- (2013) Minoru Kanehisa et al. NUCLEIC ACIDS RESEARCH
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
- (2012) Oliver D. K. Maddocks et al. NATURE
- Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
- (2008) Alexander Seiler et al. Cell Metabolism
- Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
- (2008) Wan Seok Yang et al. CHEMISTRY & BIOLOGY
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