Characterization of a patient-derived variant of GPX4 for precision therapy
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Title
Characterization of a patient-derived variant of GPX4 for precision therapy
Authors
Keywords
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Journal
Nature Chemical Biology
Volume 18, Issue 1, Pages 91-100
Publisher
Springer Science and Business Media LLC
Online
2021-12-21
DOI
10.1038/s41589-021-00915-2
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Note: Only part of the references are listed.- Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities
- (2021) Dorian M. Cheff et al. Orphanet Journal of Rare Diseases
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- (2018) Irina Ingold et al. CELL
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- (2018) Asa Hatami et al. FEBS Journal
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- FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
- (2018) Michael M. Gaschler et al. Nature Chemical Biology
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
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- (2017) Vasanthi S. Viswanathan et al. NATURE
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- (2016) Kenichi Shimada et al. Nature Chemical Biology
- Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
- (2016) Wan Seok Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferroptosis: Death by Lipid Peroxidation
- (2016) Wan Seok Yang et al. TRENDS IN CELL BIOLOGY
- Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4
- (2016) Robert Janowski et al. Acta Crystallographica Section F-Structural Biology Communications
- Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway
- (2015) Qin Wang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility
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- (2015) Anna Kaplan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- Regulation of Ferroptotic Cancer Cell Death by GPX4
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- Docking Covalent Inhibitors: A Parameter Free Approach To Pose Prediction and Scoring
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- (2014) Amanda C Smith et al. JOURNAL OF MEDICAL GENETICS
- Glutathione peroxidases
- (2012) Regina Brigelius-Flohé et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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- (2012) Si-Eun Yoo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme
- (2011) Alexander M. Mannes et al. FASEB JOURNAL
- Integration, scaling, space-group assignment and post-refinement
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- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Molecular replacement withMOLREP
- (2009) Alexei Vagin et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration
- (2009) Eva K. Wirth et al. FASEB JOURNAL
- The Catalytic Site of Glutathione Peroxidases
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- (2008) Alexander Seiler et al. Cell Metabolism
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