A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

T Cell Activation Depends on Extracellular Alanine

(2019) Noga Ron-Harel et al.   Cell Reports

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors

(2018) Wenyun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Prognostic significance of G6PD expression and localization in lung adenocarcinoma

(2018) Ryo Nagashio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo

(2018) Luigi Mele et al.   Cell Death & Disease

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

Chemical Basis for Deuterium Labeling of Fat and NADPH

(2017) Zhaoyue Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

(2017) Gregory S. Ducker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants

(2017) Anna D. Cunningham et al.   Cell Reports

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

(2017) Giang T. Nguyen et al.   Frontiers in Cellular and Infection Microbiology

Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma

(2017) Qiao Zhang et al.   Journal of Cancer

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma

(2017) Marta Anna Kowalik et al.   Frontiers in Oncology

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

(2016) Noga Ron-Harel et al.   Cell Metabolism

HDAC5 controls the functions of Foxp3+ T-regulatory and CD8+ T cells

(2016) Haiyan Xiao et al.   INTERNATIONAL JOURNAL OF CANCER

NADPH Oxidase–Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses

(2016) Lindsey E. Padgett et al.   JOURNAL OF IMMUNOLOGY

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

(2016) Edouard Mullarky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma

(2015) Haihong Pu et al.   World Journal of Surgical Oncology

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

(2012) Robert C. Stanton   IUBMB LIFE

Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase

(2012) Niall M. Hamilton et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass Spectrometer

(2010) Wenyun Lu et al.   ANALYTICAL CHEMISTRY

Dehydroepiandrosterone inhibits the proliferation and induces the death of HPV-positive and HPV-negative cervical cancer cells through an androgen- and estrogen-receptor independent mechanism

(2009) Roma A. Girón et al.   FEBS Journal

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Glucose-6-phosphate dehydrogenase deficiency

(2008) MD Cappellini et al.   LANCET