PLA2G6 guards placental trophoblasts against ferroptotic injury

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Oxygen and development of the human placenta

(2020) Graham J Burton et al.   REPRODUCTION

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

(2019) Shu-Wing Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Prominin-2 Suppresses Ferroptosis Sensitivity

(2019) Alexia Belavgeni et al.   DEVELOPMENTAL CELL

miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia

(2019) Heng Zhang et al.   Redox Biology

Pathophysiology of placental-derived fetal growth restriction

(2018) Graham J. Burton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxidative Stress in Preeclampsia and Placental Diseases

(2018) Rajaa Aouache et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative stress in placental pathology

(2018) Mirthe H. Schoots et al.   PLACENTA

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Preterm birth and oxidative stress: Effects of acute physical exercise and hypoxia physiological responses

(2018) Agnès Martin et al.   Redox Biology

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Oxidative Stress and Preterm Birth: An Integrative Review

(2018) Tiffany A. Moore et al.   Biological Research for Nursing

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE

(2018) Tamil S. Anthonymuthu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

(2017) Gao-Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treating the dysfunctional placenta

(2017) Colin P Sibley   JOURNAL OF ENDOCRINOLOGY

PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway

(2017) Ching-Chi Chiu et al.   Oncotarget

Hypoxia and Placental Development

(2017) Michael J. Soares et al.   Birth Defects Research

4-Hydroxy-2-nonenal: a critical target in oxidative stress?

(2016) Mason Breitzig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Variations of malondialdehyde in pre-eclampsia

(2016) Maryam Khoubnasabjafari et al.   HYPERTENSION IN PREGNANCY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Editorial: Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes

(2016) Angel Catalá et al.   Frontiers in Physiology

Evaluation of Glutathione Peroxidase 4 role in Preeclampsia

(2016) Xinguo Peng et al.   Scientific Reports

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Cell Signaling Pathways Involved During Invasion and Syncytialization of Trophoblast Cells

(2015) Satish Kumar Gupta et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Loss ofPLA2G6leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

(2015) Kerri J. Kinghorn et al.   BRAIN

Calcium-independent phospholipases A2and their roles in biological processes and diseases

(2015) Sasanka Ramanadham et al.   JOURNAL OF LIPID RESEARCH

Hypoxia-induced force increase (HIFI) is a novel mechanism underlying the strengthening of labor contractions, produced by hypoxic stresses

(2015) Mohammed Alotaibi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Group VIA Phospholipase A2Mitigates Palmitate-induced β-Cell Mitochondrial Injury and Apoptosis

(2014) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

(2014) Dirk Heckl et al.   NATURE BIOTECHNOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Anti-inflammatory prostaglandins for the prevention of preterm labour

(2014) Lynne Sykes et al.   REPRODUCTION

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

A Role for Nrf2 in Redox Signalling of the Invasive Extravillous Trophoblast in Severe Early Onset IUGR Associated with Preeclampsia

(2012) Nisreen Kweider et al.   PLoS One

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility

(2011) Alvar D. Gossert et al.   JOURNAL OF BIOMOLECULAR NMR

Review: Oxygen and trophoblast biology – A source of controversy

(2011) M.G. Tuuli et al.   PLACENTA

MiR-205 silences MED1 in hypoxic primary human trophoblasts

(2010) Jean-Francois Mouillet et al.   FASEB JOURNAL

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy

(2010) H.D. Mistry et al.   PLACENTA

Catalytic mechanisms and specificities of glutathione peroxidases: Variations of a basic scheme

(2009) Stefano Toppo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Eicosanoid signalling pathways in the heart

(2008) C. M. Jenkins et al.   CARDIOVASCULAR RESEARCH