Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

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Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells

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Ferroptosis as a target for protection against cardiomyopathy

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“Redox lipidomics technology: Looking for a needle in a haystack"

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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

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Regulation of lipid peroxidation and ferroptosis in diverse species

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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Autophagy inhibitor enhance ZnPc/BSA nanoparticle induced photodynamic therapy by suppressing PD-L1 expression in osteosarcoma immunotherapy

(2018) Wei Yu et al.   BIOMATERIALS

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Iron and ferroptosis: A still ill-defined liaison

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Comparative in vitro study of photodynamic activity of hypericin and hypericinates in MCF-7 cells

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

(2017) Demian van Straten et al.   Cancers

Autophagy promotes ferroptosis by degradation of ferritin

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An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline

(2016) Jiangting Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Glutaminolysis and Transferrin Regulate Ferroptosis

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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Photodynamic oxidation ofEscherichia colimembrane phospholipids: new insights based on lipidomics

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Mitoferrin-2-dependent Mitochondrial Iron Uptake Sensitizes Human Head and Neck Squamous Carcinoma Cells to Photodynamic Therapy

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The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

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Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

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Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

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