Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals

(2020) Jia-Fei Poon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

(2020) Michelle Riegman et al.   NATURE CELL BIOLOGY

Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease

(2020) Jun Liu et al.   ACS Medicinal Chemistry Letters

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

(2020) Wei Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

(2018) Lars Devisscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lipid Peroxidation: Kinetics, Mechanisms, and Products

(2017) Zosia A. M. Zielinski et al.   JOURNAL OF ORGANIC CHEMISTRY

Phenoxazine: A Privileged Scaffold for Radical-Trapping Antioxidants

(2017) Luke A. Farmer et al.   JOURNAL OF ORGANIC CHEMISTRY

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

(2016) Sam Hofmans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection

(2016) Maike J. Ohlow et al.   PHARMACEUTICAL RESEARCH

A Continuous Visible Light Spectrophotometric Approach To Accurately Determine the Reactivity of Radical-Trapping Antioxidants

(2015) Evan A. Haidasz et al.   JOURNAL OF ORGANIC CHEMISTRY

The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice

(2015) Phuriphong Songarj et al.   NEUROSCIENCE LETTERS

Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective

(2014) Keith U. Ingold et al.   CHEMICAL REVIEWS

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein

(2014) Xiang Zhang et al.   Applied Sciences-Basel

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

(2013) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Rate Constants for Peroxidation of Polyunsaturated Fatty Acids and Sterols in Solution and in Liposomes

(2009) Libin Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY