Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes

Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling

(2023) Jens V. Andersen et al.   Essays in Biochemistry

Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer’s disease

(2023) Kyle J. Brymer et al.   Acta Neuropathologica Communications

Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo

(2022) Laura M McNair et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

How expensive is the astrocyte?

(2022) LF Barros   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Physiological synaptic activity and recognition memory require astroglial glutamine

(2022) Giselle Cheung et al.   Nature Communications

Metabolic changes favor the activity and heterogeneity of reactive astrocytes

(2022) Xiao-Yi Xiong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Teriflunomide shifts the astrocytic bioenergetic profile from oxidative metabolism to glycolysis and attenuates TNFα-induced inflammatory responses

(2022) Parijat Kabiraj et al.   Scientific Reports

Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model

(2022) Douglas L. Rothman et al.   JOURNAL OF NEUROCHEMISTRY

Divergent Cellular Energetics, Glutamate Metabolism, and Mitochondrial Function Between Human and Mouse Cerebral Cortex

(2022) Emil W. Westi et al.   MOLECULAR NEUROBIOLOGY

β-Hydroxybutyrate and Medium-Chain Fatty Acids are Metabolized by Different Cell Types in Mouse Cerebral Cortex Slices

(2022) Jens V. Andersen et al.   NEUROCHEMICAL RESEARCH

Microglia states and nomenclature: A field at its crossroads

(2022) Rosa C. Paolicelli et al.   NEURON

Astrocyte energy and neurotransmitter metabolism in Alzheimer’s disease: Integration of the glutamate/GABA-glutamine cycle

(2022) Jens V. Andersen et al.   PROGRESS IN NEUROBIOLOGY

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

(2021) Guoyuan Qi et al.   Cell Reports

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

(2021) Grzegorz Sienski et al.   Science Translational Medicine

Disruption of Glutamate Transport and Homeostasis by Acute Metabolic Stress

(2021) Stefan Passlick et al.   Frontiers in Cellular Neuroscience

Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease

(2021) Jordi Duran et al.   BRAIN

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

(2021) Chao Wang et al.   NEURON

Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons

(2021) Felicia Mermer et al.   BRAIN

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

(2021) Ramon C. Sun et al.   Cell Metabolism

Astrocyte-neuron metabolic cooperation shapes brain activity

(2021) Gilles Bonvento et al.   Cell Metabolism

Dietary medium chain triglycerides for management of epilepsy: New data from human, dog, and rodent studies

(2021) Felicity Y. Han et al.   EPILEPSIA

Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes

(2021) Lucile Ben Haim et al.   GLIA

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

(2021) Brandon C. Farmer et al.   Molecular Neurodegeneration

Ceftriaxone regulates glutamate production and vesicular assembly in presynaptic terminals through GLT-1 in APP/PS1 mice

(2021) ShuJuan Fan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

(2021) Jens V. Andersen et al.   NEUROPHARMACOLOGY

Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology

(2021) Michael Tran Duong et al.   NUCLEAR MEDICINE COMMUNICATIONS

Astrocytic processes: from tripartite synapses to the active milieu

(2021) Alexey Semyanov et al.   TRENDS IN NEUROSCIENCES

Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

(2021) Claudia Salcedo et al.   Frontiers in Aging Neuroscience

Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply

(2021) Jens V. Andersen et al.   Molecular Brain

Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease

(2021) Amit Kumar et al.   JOURNAL OF NEUROCHEMISTRY

Neurotoxic reactive astrocytes induce cell death via saturated lipids

(2021) Kevin A. Guttenplan et al.   NATURE

Glial decline and loss of homeostatic support rather than inflammation defines cognitive aging

(2021) Alexei Verkhratsky et al.   Neural Regeneration Research

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

(2021) Xianyuan Xiang et al.   Science Translational Medicine

Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus

(2021) Theresa S. Rimmele et al.   Frontiers in Cellular Neuroscience

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

(2021) Jens V. Andersen et al.   Cell Death & Disease

AMP‐activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics

(2020) Caroline M. Voss et al.   GLIA

Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions

(2020) Michael B. Robinson et al.   NEUROCHEMICAL RESEARCH

Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus

(2020) Laura F. McNair et al.   NEUROCHEMICAL RESEARCH

An atlas of the protein-coding genes in the human, pig, and mouse brain

(2020) Evelina Sjöstedt et al.   SCIENCE

A Reappraisal of GAT-1 Localization in Neocortex

(2020) Giorgia Fattorini et al.   Frontiers in Cellular Neuroscience

Molecular mechanisms of K + clearance and extracellular space shrinkage—Glia cells as the stars

(2020) Nanna MacAulay   GLIA

Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes

(2020) Trevor Kirby et al.   METABOLIC BRAIN DISEASE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Extensive astrocyte metabolism of γ‐aminobutyric acid ( GABA ) sustains glutamine synthesis in the mammalian cerebral cortex

(2020) Jens V. Andersen et al.   GLIA

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

L-Serine links metabolism with neurotransmission

(2020) Marianne Maugard et al.   PROGRESS IN NEUROBIOLOGY

Decanoic Acid and Not Octanoic Acid Stimulates Fatty Acid Synthesis in U87MG Glioblastoma Cells: A Metabolomics Study

(2020) Fabrizio Damiano et al.   Frontiers in Neuroscience

Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate–Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na+/K+ Pumping Rates

(2020) Gerald A. Dienel et al.   NEUROCHEMICAL RESEARCH

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice

(2020) Giulia Dematteis et al.   Cell Death & Disease

Metabolic alterations in Parkinson’s disease astrocytes

(2020) Tuuli-Maria Sonninen et al.   Scientific Reports

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

(2020) Jens V. Andersen et al.   NEUROBIOLOGY OF DISEASE

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

(2019) Brandon Farmer et al.   Cells

Microglia-Specific Metabolic Changes in Neurodegeneration

(2019) Blanca I. Aldana   JOURNAL OF MOLECULAR BIOLOGY

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

(2019) Mélanie Fortier et al.   Alzheimers & Dementia

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function

(2019) Laura F. McNair et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase

(2019) Wendy Xin et al.   Cell Reports

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

(2019) Caroline Fecher et al.   NATURE NEUROSCIENCE

Microglial expression of GAT‐1 in the cerebral cortex

(2019) Giorgia Fattorini et al.   GLIA

Astrocyte molecular signatures in Huntington’s disease

(2019) Blanca Diaz-Castro et al.   Science Translational Medicine

Parkinson disease and the risk of epileptic seizures

(2018) Katharina Gruntz et al.   ANNALS OF NEUROLOGY

GSEA of mouse and human mitochondriomes reveals fatty acid oxidation in astrocytes

(2018) Abel Eraso-Pichot et al.   GLIA

Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease

(2018) Etienne Croteau et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic glycogen metabolism in the healthy and diseased brain

(2018) Lasse K. Bak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

(2018) Lasse K. Bak et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders

(2018) Katrin Augustin et al.   LANCET NEUROLOGY

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

(2018) Brian A Gordon et al.   LANCET NEUROLOGY

Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes

(2018) Lambros Mathioudakis et al.   NEUROCHEMICAL RESEARCH

Huntington's disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1

(2018) Robert B. Laprairie et al.   NEUROCHEMISTRY INTERNATIONAL

Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus

(2018) Yun Zhou et al.   NEUROCHEMISTRY INTERNATIONAL

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Integrative Characterization of the R6/2 Mouse Model of Huntington’s Disease Reveals Dysfunctional Astrocyte Metabolism

(2018) Niels H. Skotte et al.   Cell Reports

GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

(2018) Paramita Mookherjee et al.   JOURNAL OF ALZHEIMERS DISEASE

Lafora disease — from pathogenesis to treatment strategies

(2018) Felix Nitschke et al.   Nature Reviews Neurology

Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration

(2018) Yun Zhou et al.   NEUROCHEMISTRY INTERNATIONAL

Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer’s disease

(2018) Stephen F. Carter et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Ceftriaxone Improves Cognitive Function and Upregulates GLT-1-Related Glutamate-Glutamine Cycle in APP/PS1 Mice

(2018) ShuJuan Fan et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

GAT-1 mediated GABA uptake in rat oligodendrocytes

(2017) Giorgia Fattorini et al.   GLIA

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation

(2017) Michaela C Hohnholt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evaluating the gray and white matter energy budgets of human brain function

(2017) Yuguo Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oligodendroglia: metabolic supporters of neurons

(2017) Thomas Philips et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation

(2017) Benjamin D. Rowlands et al.   JOURNAL OF NEUROCHEMISTRY

Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

(2017) Jens Velde Andersen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glutamate-Dependent Translational Control of Glutamine Synthetase in Bergmann Glia Cells

(2017) Reynaldo Tiburcio-Félix et al.   MOLECULAR NEUROBIOLOGY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

[18F]FDG PET signal is driven by astroglial glutamate transport

(2017) Eduardo R Zimmer et al.   NATURE NEUROSCIENCE

Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS

(2017) Niels Westergaard et al.   NEUROCHEMICAL RESEARCH

Twenty-seven Years of Cerebral Pyruvate Recycling

(2017) Sebastián Cerdán   NEUROCHEMICAL RESEARCH

Branched-Chain Amino Acids and Brain Metabolism

(2017) Justin E. Sperringer et al.   NEUROCHEMICAL RESEARCH

β-Hydroxybutyrate Boosts Mitochondrial and Neuronal Metabolism but is not Preferred Over Glucose Under Activated Conditions

(2017) Lavanya B. Achanta et al.   NEUROCHEMICAL RESEARCH

Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation

(2017) Dora Ravasz et al.   NEUROCHEMISTRY INTERNATIONAL

Phenotype of GABA-transaminase deficiency

(2017) Mary Kay Koenig et al.   NEUROLOGY

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine

(2017) Manuel van Gijsel-Bonnello et al.   PLoS One

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

(2016) Stephen C. Cunnane et al.   Annals of the New York Academy of Sciences

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte–neuron lactate and ketone body shuttle systems

(2016) Jonathan Thevenet et al.   FASEB JOURNAL

Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes

(2016) Jakob D. Nissen et al.   GLIA

Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage

(2016) Naomi L Sayre et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

(2016) Kah Ni Tan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Compartmentalised energy metabolism supporting glutamatergic neurotransmission in response to increased activity in the rat cerebral cortex: A 13C MRS study in vivo at 14.1 T

(2016) Sarah Sonnay et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

(2016) Peter Schönfeld et al.   JOURNAL OF LIPID RESEARCH

Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases

(2016) Mary C. McKenna et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs

(2016) José Iglesias et al.   MOLECULAR NEUROBIOLOGY

Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-13C]Glucose and [1,2-13C]Acetate as Substrates

(2016) Laura F. McNair et al.   NEUROCHEMICAL RESEARCH

GLT-1: The elusive presynaptic glutamate transporter

(2016) Theresa S. Rimmele et al.   NEUROCHEMISTRY INTERNATIONAL

Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism

(2016) P. Malaspina et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal vs glial glutamate uptake: Resolving the conundrum

(2016) N.C. Danbolt et al.   NEUROCHEMISTRY INTERNATIONAL

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

(2016) J. K. Hefendehl et al.   Nature Communications

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Seizure control by decanoic acid through direct AMPA receptor inhibition

(2015) Pishan Chang et al.   BRAIN

Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes

(2015) Jakob D. Nissen et al.   GLIA

Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity

(2015) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

(2015) Leif Hertz et al.   JOURNAL OF NEUROCHEMISTRY

Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

(2015) G. T. Petr et al.   JOURNAL OF NEUROSCIENCE

Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized ratIn vivo

(2015) Anant B. Patel et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Maintaining the presynaptic glutamate supply for excitatory neurotransmission

(2015) Mari-Carmen Marx et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

(2015) Joannee Zumkehr et al.   NEUROBIOLOGY OF AGING

Glutamate: Where does it come from and where does it go?

(2015) Grethe M. Olsen et al.   NEUROCHEMISTRY INTERNATIONAL

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

(2015) Michael Schöll et al.   Scientific Reports

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

(2015) Melis Karaca et al.   Cell Reports

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling Revealed by Cross-Linking and Mass Spectrometry

(2014) Fei Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington’s disease

(2014) M Valenza et al.   CELL DEATH AND DIFFERENTIATION

Expression of Gls and Gls2 glutaminase isoforms in astrocytes

(2014) Carolina Cardona et al.   GLIA

Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes

(2014) Piotr Mamczur et al.   GLIA

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

(2014) Sean David Hughes et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate synthesis has to be matched by its degradation - where do all the carbons go?

(2014) Ursula Sonnewald   JOURNAL OF NEUROCHEMISTRY

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle

(2014) A. B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Astrocyte–Neuronal Interactions After Hypoxia-Ischemia in the Neonatal Brain in Female and Male Rats

(2014) Tora Sund Morken et al.   STROKE

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

A quantitative analysis of cellular and synaptic localization of GAT-1 and GAT-3 in rat neocortex

(2013) Marcello Melone et al.   Brain Structure & Function

Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression

(2013) Geraldine T. Petr et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain Alanine Formation as an Ammonia-Scavenging Pathway during Hyperammonemia: Effects of Glutamine Synthetase Inhibition in Rats and Astrocyte—Neuron Co-Cultures

(2013) Sherry Dadsetan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glutamatergic and GABAergic energy metabolism measured in the rat brain by13C NMR spectroscopy at 14.1 T

(2013) João M. N. Duarte et al.   JOURNAL OF NEUROCHEMISTRY

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

GABA and Glutamate Transporters in Brain

(2013) Yun Zhou et al.   Frontiers in Endocrinology

Inhibitors of Glutamate Dehydrogenase Block Sodium-Dependent Glutamate Uptake in Rat Brain Membranes

(2013) Brendan S. Whitelaw et al.   Frontiers in Endocrinology

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA

(2013) Arne Schousboe et al.   Frontiers in Endocrinology

Deletion of the γ-Aminobutyric Acid Transporter 2 (GAT2 and SLC6A13) Gene in Mice Leads to Changes in Liver and Brain Taurine Contents

(2012) Yun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

(2012) Francesca Frigerio et al.   JOURNAL OF NEUROCHEMISTRY

Ketone bodies in epilepsy

(2012) Melanie A. McNally et al.   JOURNAL OF NEUROCHEMISTRY

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

The Density of EAAC1 (EAAT3) Glutamate Transporters Expressed by Neurons in the Mammalian CNS

(2012) S. Holmseth et al.   JOURNAL OF NEUROSCIENCE

Seizures in juvenile Huntington's disease: Frequency and characterization in a multicenter cohort

(2012) Leslie J. Cloud et al.   MOVEMENT DISORDERS

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Substrate Competition Studies Demonstrate Oxidative Metabolism of Glucose, Glutamate, Glutamine, Lactate and 3-Hydroxybutyrate in Cortical Astrocytes from Rat Brain

(2012) Mary C. McKenna   NEUROCHEMICAL RESEARCH

Metabolism, Compartmentation, Transport and Production of Acetate in the Cortical Brain Tissue Slice

(2012) Caroline Rae et al.   NEUROCHEMICAL RESEARCH

siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

(2012) Dorte M. Skytt et al.   NEUROCHEMISTRY INTERNATIONAL

The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism

(2012) Deborah E. Bauer et al.   NEUROCHEMISTRY INTERNATIONAL

Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control

(2012) Nicole M. Rowley et al.   NEUROCHEMISTRY INTERNATIONAL

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The ketogenic diet: metabolic influences on brain excitability and epilepsy

(2012) Andrew Lutas et al.   TRENDS IN NEUROSCIENCES

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Labeled Acetate as a Marker of Astrocytic Metabolism

(2011) Matthias T Wyss et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Co-compartmentalization of the Astroglial Glutamate Transporter, GLT-1, with Glycolytic Enzymes and Mitochondria

(2011) E. N. Genda et al.   JOURNAL OF NEUROSCIENCE

Estimation of intracellular fluxes in cerebellar neurons after hypoglycemia: Importance of the pyruvate recycling pathway and glutamine oxidation

(2011) Ana I. Amaral et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cholesterol metabolism in Huntington disease

(2011) Joanna M. Karasinska et al.   Nature Reviews Neurology

Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

(2011) Sherry Dadsetan et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: Increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression

(2011) E.K. Michaelis et al.   NEUROCHEMISTRY INTERNATIONAL

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Glutamine synthetase deficiency in murine astrocytes results in neonatal death

(2010) Youji He et al.   GLIA

Uptake, Release, and Metabolism of Citrate in Neurons and Astrocytes in Primary Cultures

(2010) Niels Westergaard et al.   JOURNAL OF NEUROCHEMISTRY

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons

(2010) Jian Zou et al.   NEUROCHEMISTRY INTERNATIONAL

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Ceftriaxone Restores Glutamate Homeostasis and Prevents Relapse to Cocaine Seeking

(2009) Lori A. Knackstedt et al.   BIOLOGICAL PSYCHIATRY

Branched-chain Amino Acid Metabolon

(2009) Mohammad Mainul Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of Aβ1-42-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer’s disease

(2009) Marie E. Gibbs et al.   JOURNAL OF NEUROCHEMISTRY

Functional significance of brain glycogen in sustaining glutamatergic neurotransmission

(2009) Helle M. Sickmann et al.   JOURNAL OF NEUROCHEMISTRY

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability

(2009) X. Bao et al.   JOURNAL OF NEUROSCIENCE

Neuronal Transporters Regulate Glutamate Clearance, NMDA Receptor Activation, and Synaptic Plasticity in the Hippocampus

(2009) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures

(2008) K. L. I. van Gassen et al.   GENES BRAIN AND BEHAVIOR

Synaptic localization of GLT-1a in the rat somatic sensory cortex

(2008) Marcello Melone et al.   GLIA

Understanding your inhibitions: effects of GABA and GABAAreceptor modulation on brain cortical metabolism

(2008) Fatima A. Nasrallah et al.   JOURNAL OF NEUROCHEMISTRY

Expression of Pyruvate Carboxylase in Cultured Oligodendroglial, Microglial and Ependymal Cells

(2008) Radovan Murin et al.   NEUROCHEMICAL RESEARCH

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE

A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: New insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)

(2008) D.N. Furness et al.   NEUROSCIENCE

Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents

(2008) A.B. Walls et al.   NEUROSCIENCE