Molecular mechanisms of K + clearance and extracellular space shrinkage—Glia cells as the stars

Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes

(2019) Clemens Reiffurth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression

(2019) Brana Rosic et al.   GLIA

Limited contribution of astroglial gap junction coupling to buffering of extracellular K + in CA1 stratum radiatum

(2019) Björn Breithausen et al.   GLIA

Diversity of astrocyte potassium channels: An update

(2018) Gerald Seifert et al.   BRAIN RESEARCH BULLETIN

Down-regulation of Inwardly Rectifying K + Currents in Astrocytes Derived from Patients with Monge’s Disease

(2018) Wei Wu et al.   NEUROSCIENCE

Cotransporter-mediated water transport underlying cerebrospinal fluid formation

(2018) Annette B. Steffensen et al.   Nature Communications

Potassium and sodium microdomains in thin astroglial processes: A computational model study

(2018) Kevin Breslin et al.   PLoS Computational Biology

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

(2018) Valerie A Larson et al.   eLife

Heterogeneity of Astrocytic and Neuronal GLT-1 at Cortical Excitatory Synapses, as Revealed by its Colocalization With Na+/K+-ATPase α Isoforms

(2018) Marcello Melone et al.   CEREBRAL CORTEX

Syncytial isopotentiality: A system-wide electrical feature of astrocytic networks in the brain

(2018) Conrad M. Kiyoshi et al.   GLIA

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Developmental maturation of activity-induced K+ and pH transients and the associated extracellular space dynamics in the rat hippocampus

(2018) Brian Roland Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model

(2017) Cordula Rakers et al.   GLIA

The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation

(2017) Anca Stoica et al.   GLIA

Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms

(2017) Brian Roland Larsen et al.   GLIA

Glial overexpression of Dube3a causes seizures and synaptic impairments in Drosophila concomitant with down regulation of the Na + /K + pump ATPα

(2017) Kevin A. Hope et al.   NEUROBIOLOGY OF DISEASE

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

The role of glial-specific Kir4.1 in normal and pathological states of the CNS

(2016) Sinifunanya E. Nwaobi et al.   ACTA NEUROPATHOLOGICA

Defective glutamate and K+clearance by cortical astrocytes in familial hemiplegic migraine type 2

(2016) Clizia Capuani et al.   EMBO Molecular Medicine

Sodium signaling and astrocyte energy metabolism

(2016) Jean-Yves Chatton et al.   GLIA

Aquaporin 4 as a NH3Channel

(2016) Mette Assentoft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role of the sodium pump in spreading ischemia in rats

(2016) Sebastian Major et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice

(2016) Anton Dvorzhak et al.   JOURNAL OF NEUROSCIENCE

Glutamate transporter activity promotes enhanced Na+/K+-ATPase-mediated extracellular K+management during neuronal activity

(2016) Brian Roland Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Extrusion versus diffusion: mechanisms for recovery from sodium loads in mouse CA1 pyramidal neurons

(2016) Miguel A. Mondragão et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model

(2016) Pernille Bøttger et al.   Scientific Reports

Managing Brain Extracellular K+ during Neuronal Activity: The Physiological Role of the Na+/K+-ATPase Subunit Isoforms

(2016) Brian Roland Larsen et al.   Frontiers in Physiology

Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury

(2016) Nasya M. Sturdivant et al.   Scientific Reports

Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation.

(2015) Greer S. Kirshenbaum et al.   BEHAVIORAL NEUROSCIENCE

High effective cytosolic H+buffering in mouse cortical astrocytes attributable to fast bicarbonate transport

(2015) Shefeeq M. Theparambil et al.   GLIA

Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity

(2015) Claudia Karus et al.   GLIA

Gap junction coupling confers isopotentiality on astrocyte syncytium

(2015) Baofeng Ma et al.   GLIA

Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading

(2015) A. B. Steffensen et al.   JOURNAL OF NEUROSCIENCE

Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes

(2015) Shefeeq M. Theparambil et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of the Astrocytic Na+, K+-ATPase in K+ Homeostasis in Brain: K+ Uptake, Signaling Pathways and Substrate Utilization

(2015) Leif Hertz et al.   NEUROCHEMICAL RESEARCH

The Expanding Spectrum of Neurological Phenotypes in Children With ATP1A3 Mutations, Alternating Hemiplegia of Childhood, Rapid-onset Dystonia-Parkinsonism, CAPOS and Beyond

(2015) Matthew T. Sweney et al.   PEDIATRIC NEUROLOGY

Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress

(2014) Hiroki Sugimoto et al.   BEHAVIOURAL BRAIN RESEARCH

Deletion of aquaporin-4 increases extracellular K+ concentration during synaptic stimulation in mouse hippocampus

(2014) Nadia Nabil Haj-Yasein et al.   Brain Structure & Function

Kir4.1-mediated spatial buffering of K+: Experimental challenges in determination of its temporal and quantitative contribution to K+clearance in the brain

(2014) Brian Roland Larsen et al.   Channels

Knock-in mouse model of alternating hemiplegia of childhood: Behavioral and electrophysiologic characterization

(2014) Arsen S. Hunanyan et al.   EPILEPSIA

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The Electrogenic Sodium Bicarbonate Cotransporter NBCe1 Is a High-Affinity Bicarbonate Carrier in Cortical Astrocytes

(2014) S. M. Theparambil et al.   JOURNAL OF NEUROSCIENCE

Distinct neurological disorders with ATP1A3 mutations

(2014) Erin L Heinzen et al.   LANCET NEUROLOGY

A Sodium-Pump-Mediated Afterhyperpolarization in Pyramidal Neurons

(2013) A. T. Gulledge et al.   JOURNAL OF NEUROSCIENCE

Enhanced inhibitory neurotransmission in the cerebellar cortex ofAtp1a3-deficient heterozygous mice

(2013) Keiko Ikeda et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuronal and Astroglial Correlates Underlying Spatiotemporal Intrinsic Optical Signal in the Rat Hippocampal Slice

(2013) Ildikó Pál et al.   PLoS One

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

Astrocytic and neuronal accumulation of elevated extracellular K+ with a 2/3 K+/Na+ flux ratio—consequences for energy metabolism, osmolarity and higher brain function

(2013) Leif Hertz et al.   Frontiers in Computational Neuroscience

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus

(2012) Nadia Nabil Haj-Yasein et al.   GLIA

Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

(2012) Christian Steinhäuser et al.   GLIA

Relationship between glial potassium regulation and axon excitability: A role for glial Kir4.1 channels

(2012) Virginia Bay et al.   GLIA

Subunit Isoform Selectivity in Assembly of Na,K-ATPase α-β Heterodimers

(2012) Elmira Tokhtaeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aquaporin-4–dependent K+and water transport modeled in brain extracellular space following neuroexcitation

(2012) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cotransport of water by Na+-K+-2Cl−cotransporters expressed inXenopusoocytes: NKCC1versusNKCC2

(2012) Thomas Zeuthen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glial K+ Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps

(2012) Nanna MacAulay et al.   NEUROCHEMICAL RESEARCH

Dynamic Volume Changes in Astrocytes Are an Intrinsic Phenomenon Mediated by Bicarbonate Ion Flux

(2012) Clare M. Florence et al.   PLoS One

Astrocytes Modulate Neural Network Activity by Ca2+-Dependent Uptake of Extracellular K+

(2012) F. Wang et al.   Science Signaling

Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier

(2011) Martine Eilert-Olsen et al.   GLIA

Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ

(2011) Julia Langer et al.   GLIA

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human kir4.1 gene (KCNJ10)

(2011) Nadia Nabil Haj-Yasein et al.   GLIA

Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus

(2011) Susan Strohschein et al.   GLIA

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Na+, K+-ATPase: Functions in the nervous system and involvement in neurologic disease

(2011) E. E. Benarroch   NEUROLOGY

Migraine- and dystonia-related disease-mutations of Na+/K+-ATPases: Relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans

(2011) Pernille Bøttger et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Astroglial networks scale synaptic activity and plasticity

(2011) U. Pannasch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Susceptibility to Cortical Spreading Depression in the Mouse Model of Familial Hemiplegic Migraine Type 2

(2011) Loredana Leo et al.   PLoS Genetics

Water Permeation through the Sodium-Dependent Galactose Cotransporter vSGLT

(2010) Seungho Choe et al.   BIOPHYSICAL JOURNAL

Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice

(2010) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Differential water permeability and regulation of three aquaporin 4 isoforms

(2009) Robert A. Fenton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Electrical coupling of astrocytes in rat hippocampal slices under physiological and simulated ischemic conditions

(2009) Guangjin Xu et al.   GLIA

Molecular genetics of migraine

(2009) Boukje de Vries et al.   HUMAN GENETICS

Water-Transporting Proteins

(2009) Thomas Zeuthen   JOURNAL OF MEMBRANE BIOLOGY

Rapid Rise of Extracellular pH Evoked by Neural Activity Is Generated by the Plasma Membrane Calcium ATPase

(2009) Sachin Makani et al.   JOURNAL OF NEUROPHYSIOLOGY

Glutamate Transporter Coupling to Na,K-ATPase

(2009) E. M. Rose et al.   JOURNAL OF NEUROSCIENCE

Synaptically induced sodium signals in hippocampal astrocytesin situ

(2009) Julia Langer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Water transport between CNS compartments: contributions of aquaporins and cotransporters

(2009) N. MacAulay et al.   NEUROSCIENCE

Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice

(2009) Hiroki Kitaura et al.   NEUROSCIENCE RESEARCH

Epilepsy, Ataxia, Sensorineural Deafness, Tubulopathy, andKCNJ10Mutations

(2009) Detlef Bockenhauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutation I810N in the  3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS

(2009) S. J. Clapcote et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG

(2009) R. Musa-Aziz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10

(2009) U. I. Scholl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices andin vivorevealed by two-photon microscopy

(2008) W. Christopher Risher et al.   GLIA

Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity

(2008) Tony Kelly et al.   GLIA

Functional implications for Kir4.1 channels in glial biology: from K+buffering to cell differentiation

(2008) Michelle L. Olsen et al.   JOURNAL OF NEUROCHEMISTRY

Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change

(2008) X. Yao et al.   JOURNAL OF NEUROSCIENCE

Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells

(2007) Hua Zhang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE