APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

(2021) Guoyuan Qi et al.   Cell Reports

Improved workflow for mass spectrometry–based metabolomics analysis of the heart

(2020) Douglas A. Andres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOE alters glucose flux through central carbon pathways in astrocytes

(2020) Holden C. Williams et al.   NEUROBIOLOGY OF DISEASE

Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur

(2020) L. Felipe Barros et al.   NEUROCHEMICAL RESEARCH

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

(2020) Alexandria N. Early et al.   Journal of Neuroinflammation

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Beyond the CNS: The many peripheral roles of APOE

(2020) Ana B. Martínez-Martínez et al.   NEUROBIOLOGY OF DISEASE

Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma

(2020) Nicholas A. Devanney et al.   EXPERIMENTAL NEUROLOGY

Lipid Droplets in Neurodegenerative Disorders

(2020) Brandon C. Farmer et al.   Frontiers in Neuroscience

Quantitative FDG-PET imaging of the effects of ApoE ε4 on longitudinal brain region-specific glucose metabolism in patients with mild cognitive impairment

(2019) Manish D. Paranjpe et al.   NeuroImage-Clinical

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

(2019) Michaël E. Belloy et al.   NEURON

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function

(2019) Adam L. Orr et al.   JOURNAL OF ALZHEIMERS DISEASE

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

(2019) Henna Konttinen et al.   Stem Cell Reports

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

(2018) Timothy J. Hohman et al.   JAMA Neurology

Missing Value Imputation Approach for Mass Spectrometry-based Metabolomics Data

(2018) Runmin Wei et al.   Scientific Reports

Alzheimer's disease: The right drug, the right time

(2018) Todd E. Golde et al.   SCIENCE

Effects of apolipoprotein E on nutritional metabolism in dementia

(2018) Brandon C. Farmer et al.   CURRENT OPINION IN LIPIDOLOGY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

(2017) Juan Carlos Polanco et al.   Nature Reviews Neurology

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

(2017) Na Zhao et al.   NEURON

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

(2017) Lance A. Johnson et al.   Scientific Reports

Late-onset Alzheimer’s disease is associated with inherent changes in bioenergetics profiles

(2017) Kai-C. Sonntag et al.   Scientific Reports

Glucose challenge test screening for prediabetes and early diabetes

(2016) S. L. Jackson et al.   DIABETIC MEDICINE

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

(2016) Michelle Perkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Age, APOE and sex: Triad of risk of Alzheimer’s disease

(2016) Brandalyn C. Riedel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Association of APOE with tau-tangle pathology with and without β-amyloid

(2016) Jose M. Farfel et al.   NEUROBIOLOGY OF AGING

Imaging brain aerobic glycolysis as a marker of synaptic plasticity

(2016) Pierre J. Magistretti   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

(2014) Jing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice

(2014) Patricia Huebbe et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner

(2014) Lance A. Johnson et al.   NEUROBIOLOGY OF DISEASE

Hormonal modulators of glial ABCA1 and apoE levels

(2013) Jianjia Fan et al.   JOURNAL OF LIPID RESEARCH

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

(2012) Hillary D. Protas et al.   JAMA Neurology

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans

(2011) Peter Rasmussen et al.   FASEB JOURNAL

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

(2010) Andrei G. Vlassenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

The stress of chess players as a model to study the effects of psychological stimuli on physiological responses: an example of substrate oxidation and heart rate variability in man

(2008) Nicolas Troubat et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice

(2008) J M Arbones-Mainar et al.   INTERNATIONAL JOURNAL OF OBESITY

Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias

(2008) L. Mosconi et al.   JOURNAL OF NUCLEAR MEDICINE