Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease

(2015) Mary T. Newport et al.   Alzheimers & Dementia

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized ratIn vivo

(2015) Anant B. Patel et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

(2015) Elisa Isopi et al.   NEUROBIOLOGY OF DISEASE

First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

(2014) Christian Hölscher   Alzheimers & Dementia

Noradrenergic Regulation of Glial Activation: Molecular Mechanisms and Therapeutic Implications

(2014) David Braun et al.   Current Neuropharmacology

Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1-weighted imaging

(2014) Junko Takahashi et al.   Geriatrics & Gerontology International

Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance

(2014) Jessica L. Seidel et al.   GLIA

The Contribution of Ketone Bodies to Basal and Activity-Dependent Neuronal Oxidation in Vivo

(2014) Golam MI Chowdhury et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal and Astrocytic Metabolism in a Transgenic Rat Model of Alzheimer's Disease

(2014) Linn Hege Nilsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester

(2014) Sami A. Hashim et al.   JOURNAL OF LIPID RESEARCH

Differential Effects of Synaptic and Extrasynaptic NMDA Receptors on A -Induced Nitric Oxide Production in Cerebrocortical Neurons

(2014) E. Molokanova et al.   JOURNAL OF NEUROSCIENCE

Astrocytic glycogenolysis: mechanisms and functions

(2014) Leif Hertz et al.   METABOLIC BRAIN DISEASE

The Glutathione System: A New Drug Target in Neuroimmune Disorders

(2014) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Why are Astrocytes Important?

(2014) Alexei Verkhratsky et al.   NEUROCHEMICAL RESEARCH

Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD

(2014) L. Mosconi et al.   NEUROLOGY

The Effects of Healthy Aging, Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease on Recollection and Familiarity: A Meta-Analytic Review

(2014) Joshua D. Koen et al.   NEUROPSYCHOLOGY REVIEW

Seizures and Epileptiform Activity in Early Alzheimer Disease: How Hard Should We Be Looking?

(2014) David Spencer   Epilepsy Currents

Amyloid-β may be released from non-junctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer’s disease: a hypothesis

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Triheptanoin Supplementation to Ketogenic Diet Curbs Cognitive Impairment in APP/PS1 Mice Used as a Model of Familial Alzheimer’s Disease

(2013) Ester Aso et al.   Current Alzheimer Research

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

Antimicrobial Effects of Virgin Coconut Oil and Its Medium-Chain Fatty Acids on Clostridium difficile

(2013) Michael Shilling et al.   JOURNAL OF MEDICINAL FOOD

Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

(2013) M. Lehmann et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly

(2013) Lidia Glodzik et al.   NEUROBIOLOGY OF AGING

Functional MRI and neural responses in a rat model of Alzheimer's disease

(2013) Basavaraju G. Sanganahalli et al.   NEUROIMAGE

Attenuating Aβ1–42-induced toxicity by a novel acetylcholinesterase inhibitor

(2013) N. Mishra et al.   NEUROSCIENCE

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease

(2013) Termpanit Chalermpalanupap et al.   Alzheimers Research & Therapy

Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer's disease

(2013) Juergen Dukart et al.   NeuroImage-Clinical

GABA and Glutamate Transporters in Brain

(2013) Yun Zhou et al.   Frontiers in Endocrinology

The Glutamate–Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation

(2013) Leif Hertz   Frontiers in Endocrinology

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA

(2013) Arne Schousboe et al.   Frontiers in Endocrinology

Medium-chain Triglyceride Ketogenic Diet, An Effective Treatment for Drug-resistant Epilepsy and A Comparison with Other Ketogenic Diets

(2013) Yeou-meiChristiana Liu et al.   Biomedical Journal

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

(2012) Misha Zilberter et al.   JOURNAL OF NEUROCHEMISTRY

Preclinical sporadic Alzheimer's disease: target for personalized diagnosis and preventive intervention

(2012) Theodore B. VanItallie   METABOLISM-CLINICAL AND EXPERIMENTAL

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance

(2012) John O’Donnell et al.   NEUROCHEMICAL RESEARCH

Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease

(2012) Rosella Abeti et al.   NEUROCHEMICAL RESEARCH

Nucleus basalis-enabled stimulus-specific plasticity in the visual cortex is mediated by astrocytes

(2012) N. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

(2012) Kieran Clarke et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hyperphosphorylated tau in young and middle-aged subjects

(2011) Adila Elobeid et al.   ACTA NEUROPATHOLOGICA

Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study

(2011) Samuel T Henderson et al.   BMC Medical Genetics

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Dynamic monitoring of cytosolic glucose in single astrocytes

(2011) Mateja Prebil et al.   GLIA

β-amyloid Peptide Binds and Regulates Ectopic ATP Synthase α-Chain on Neural Surface

(2011) San-Li Xing et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

(2011) Renata Leke et al.   JOURNAL OF NEUROCHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo

(2011) N. Takata et al.   JOURNAL OF NEUROSCIENCE

13C MRS studies of neuroenergetics and neurotransmitter cycling in humans

(2011) Douglas L. Rothman et al.   NMR IN BIOMEDICINE

Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study

(2011) Napapon Sailasuta et al.   Neuropsychiatric Disease and Treatment

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?

(2010) Eric H. Kossoff et al.   EPILEPSIA

Knockout of GAD65 has Major Impact on Synaptic GABA Synthesized from Astrocyte-Derived Glutamine

(2010) Anne B Walls et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

(2010) Anne B. Walls et al.   JOURNAL OF NEUROCHEMISTRY

Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and [Ca2+]i

(2010) Leif Hertz et al.   NEUROCHEMISTRY INTERNATIONAL

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Availability of neurotransmitter glutamate is diminished when β-hydroxybutyrate replaces glucose in cultured neurons

(2009) Trine M Lund et al.   JOURNAL OF NEUROCHEMISTRY

Rescue of Aβ1-42-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer’s disease

(2009) Marie E. Gibbs et al.   JOURNAL OF NEUROCHEMISTRY

Does Alzheimer's disease begin in the brainstem?

(2009) G. Simic et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Hypometabolism as a therapeutic target in Alzheimer's disease

(2008) Lauren C Costantini et al.   BMC NEUROSCIENCE

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

Locus Coeruleus α-Adrenergic–Mediated Activation of Cortical Astrocytes In Vivo

(2008) Lane K. Bekar et al.   CEREBRAL CORTEX

Functional Consequences of Locus Coeruleus Degeneration in Alzheimers Disease

(2008) David Weinshenker   Current Alzheimer Research

Regulation of hexokinase binding to VDAC

(2008) John G. Pastorino et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Memory loss caused by β-amyloid protein is rescued by a β3-adrenoceptor agonist

(2008) Marie E. Gibbs et al.   NEUROBIOLOGY OF AGING