Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

(2016) Jingshu Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

(2016) Tal Iram et al.   NEUROBIOLOGY OF DISEASE

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

(2015) Kévin Baranger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease

(2015) Heather M. Wilkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment

(2015) Matjaž Stenovec et al.   GLIA

Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity

(2015) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding

(2015) Niloufar Kavian et al.   Arthritis & Rheumatology

WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β1-42 Effects on Astrocytes in Primary Culture

(2015) Diana Aguirre-Rueda et al.   PLoS One

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease

(2014) Raúl González-Domínguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Novel Multi-Target Iron Chelator, M30 Modulates HIF-1α-Related Glycolytic Genes and Insulin Signaling Pathway in the Frontal Cortex of APP/PS1 Alzheimer’s Disease Mice

(2014) Danit Mechlovich et al.   Current Alzheimer Research

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease

(2014) Stéphane D. Girard et al.   HIPPOCAMPUS

Neuronal and Astrocytic Metabolism in a Transgenic Rat Model of Alzheimer's Disease

(2014) Linn Hege Nilsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Metabotyping of Docosahexaenoic Acid - Treated Alzheimer’s Disease Cell Model

(2014) Priti Bahety et al.   PLoS One

Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model

(2013) Dario Brunetti et al.   BRAIN

Metabolic Perturbation of an Essential Pathway: Evaluation of a Glycine Precursor of Coenzyme A

(2013) Michael Rothmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

Carbon Monoxide Modulates Apoptosis by Reinforcing Oxidative Metabolism in Astrocytes

(2012) Ana S. Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

RETRACTED: Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice

(2012) Wei Zhang et al.   NEUROBIOLOGY OF AGING

The effects of amyloid-β42 oligomer on the proliferation and activation of astrocytes in vitro

(2011) Lingling Hou et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex

(2011) Qingli Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury

(2010) Emilie Cornille et al.   BMC NEUROSCIENCE

Extended Ischemia Prevents HIF1α Degradation at Reoxygenation by Impairing Prolyl-hydroxylation

(2010) Anna Serra-Pérez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Amyloid-  Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

(2010) I. Allaman et al.   JOURNAL OF NEUROSCIENCE

Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration

(2010) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

(2009) Soraya L. Valles et al.   BRAIN RESEARCH

The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide

(2009) David Schubert et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes

(2008) Guanghu Wang et al.   GLIA

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Protection against cerebral malaria by the low-molecular-weight thiol pantethine

(2008) M.-F. Penet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA